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Title: Method and apparatus for fringe-scanning chromosome analysis

Abstract

Apparatus and method are provided for analyzing sub-micron-sized features of microscopic particles. Two central features of the invention are (1) constraining microscopic particles to flow with substantially constant orientation through a predetermined interference fringe pattern, and (2) estimating particle structure by analyzing its fringe profile. The invention allows nearly an order of magnitude higher resolution of chromosome structure than possible with currently available flow system techniques. The invention allows rapid and accurate flow karyotyping of chromosomes.

Inventors:
 [1];  [2];  [2]
+ Show Inventor Affiliations
  1. Palo Alto, CA
  2. Livermore, CA
Issue Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
OSTI Identifier:
865886
Patent Number(s):
4596036
Assignee:
United States of America as represented by United States (Washington, DC)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; apparatus; fringe-scanning; chromosome; analysis; provided; analyzing; sub-micron-sized; features; microscopic; particles; central; constraining; flow; substantially; constant; orientation; predetermined; interference; fringe; pattern; estimating; particle; structure; profile; allows; nearly; magnitude; resolution; currently; available; techniques; rapid; accurate; karyotyping; chromosomes; microscopic particles; currently available; substantially constant; fringe pattern; interference fringe; analysis apparatus; /382/356/377/

Citation Formats

Norgren, Richard M, Gray, Joe W, and Hirschfeld, Tomas B. Method and apparatus for fringe-scanning chromosome analysis. United States: N. p., 1986. Web.
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Norgren, Richard M, Gray, Joe W, & Hirschfeld, Tomas B. Method and apparatus for fringe-scanning chromosome analysis. United States.
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Norgren, Richard M, Gray, Joe W, and Hirschfeld, Tomas B. Wed . "Method and apparatus for fringe-scanning chromosome analysis". United States. https://www.osti.gov/servlets/purl/865886.
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@article{osti_865886,
title = {Method and apparatus for fringe-scanning chromosome analysis},
author = {Norgren, Richard M and Gray, Joe W and Hirschfeld, Tomas B},
abstractNote = {Apparatus and method are provided for analyzing sub-micron-sized features of microscopic particles. Two central features of the invention are (1) constraining microscopic particles to flow with substantially constant orientation through a predetermined interference fringe pattern, and (2) estimating particle structure by analyzing its fringe profile. The invention allows nearly an order of magnitude higher resolution of chromosome structure than possible with currently available flow system techniques. The invention allows rapid and accurate flow karyotyping of chromosomes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1986},
month = {Wed Jan 01 00:00:00 EST 1986}
}
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