Method and apparatus for fringe-scanning chromosome analysis

Title: Method and apparatus for fringe-scanning chromosome analysis

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Abstract

Apparatus and method are provided for analyzing sub-micron-sized features of microscopic particles. Two central features of the invention are (1) constraining microscopic particles to flow with substantially constant orientation through a predetermined interference fringe pattern, and (2) estimating particle structure by analyzing its fringe profile. The invention allows nearly an order of magnitude higher resolution of chromosome structure than possible with currently available flow system techniques. The invention allows rapid and accurate flow karyotyping of chromosomes.

Inventors:: Norgren, R.M.; Gray, J.W.; Hirschfeld, T.B.

Issue Date:: 1983-08-31

OSTI Identifier:: 6966114

Application Number:: ON: DE84010873

Assignee:: Dept. of Energy ERA-09-027111; EDB-84-086170

DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Resource Relation:: Other Information: Portions are illegible in microfiche products

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; CELL FLOW SYSTEMS; DESIGN; INTERFEROMETRY; ALGORITHMS; CHROMOSOMES; FOURIER TRANSFORMATION; KARYOTYPE; LASERS; INTEGRAL TRANSFORMATIONS; MATHEMATICAL LOGIC; TRANSFORMATIONS; 550300* - Cytology

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                    Norgren, R.M., Gray, J.W., and Hirschfeld, T.B. Method and apparatus for fringe-scanning chromosome analysis.  United States: N. p., 1983. 
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                    Norgren, R.M., Gray, J.W., & Hirschfeld, T.B. Method and apparatus for fringe-scanning chromosome analysis.  United States.

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                    Norgren, R.M., Gray, J.W., and Hirschfeld, T.B. Wed .  
        "Method and apparatus for fringe-scanning chromosome analysis".  United States.

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@article{osti_6966114,

  title        = {Method and apparatus for fringe-scanning chromosome analysis},

  author       = {Norgren, R.M. and Gray, J.W. and Hirschfeld, T.B.},

  abstractNote = {Apparatus and method are provided for analyzing sub-micron-sized features of microscopic particles. Two central features of the invention are (1) constraining microscopic particles to flow with substantially constant orientation through a predetermined interference fringe pattern, and (2) estimating particle structure by analyzing its fringe profile. The invention allows nearly an order of magnitude higher resolution of chromosome structure than possible with currently available flow system techniques. The invention allows rapid and accurate flow karyotyping of chromosomes.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1983},

  month        = {8}

}

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