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Title: Assessing endothelial function and providing calibrated UFMD data using a blood pressure cuff

Abstract

Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve using a cuff to apply pressure to an artery in a subject to determine a plurality of baseline values for a parameter related to endothelial function as a function of applied pressure (P.sub.m); b) applying a stimulus to the subject; and applying external pressure P.sub.m to the artery to determine a plurality of stimulus-effected values for the parameter related to endothelial function as a function of applied pressure (P.sub.m); where the baseline values are determined from measurements made when said mammal is not substantially effected by said stimulus and differences in said baseline values and said stimulus-effected values provide a measure of endothelial function in said mammal.

Inventors:
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1464470
Patent Number(s):
10028664
Application Number:
15/680,082
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16H - HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2017 Aug 17
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Maltz, Jonathan S. Assessing endothelial function and providing calibrated UFMD data using a blood pressure cuff. United States: N. p., 2018. Web.
Maltz, Jonathan S. Assessing endothelial function and providing calibrated UFMD data using a blood pressure cuff. United States.
Maltz, Jonathan S. Tue . "Assessing endothelial function and providing calibrated UFMD data using a blood pressure cuff". United States. https://www.osti.gov/servlets/purl/1464470.
@article{osti_1464470,
title = {Assessing endothelial function and providing calibrated UFMD data using a blood pressure cuff},
author = {Maltz, Jonathan S.},
abstractNote = {Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve using a cuff to apply pressure to an artery in a subject to determine a plurality of baseline values for a parameter related to endothelial function as a function of applied pressure (P.sub.m); b) applying a stimulus to the subject; and applying external pressure P.sub.m to the artery to determine a plurality of stimulus-effected values for the parameter related to endothelial function as a function of applied pressure (P.sub.m); where the baseline values are determined from measurements made when said mammal is not substantially effected by said stimulus and differences in said baseline values and said stimulus-effected values provide a measure of endothelial function in said mammal.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {7}
}

Works referenced in this record:

Ocular plethysmograph
patent, February 1979


Impedance plethysmograph
patent, September 1979


Strain gauge plethysmograph
patent, March 1981


Plethysmograph cuff bladder
patent, June 1986


Tourniquet for regulating applied pressures
patent, September 1991


Ultrasonic plethysmograph
patent, February 1992


Apparatus and method for vascular examination of a limb
patent, February 1992


Ultrasonic plethysmograph
patent, February 1993


Method of measuring blood pressure with a plethysmograph
patent, December 1993


Ultrasonic plethysmograph
patent, March 1994


Plethysmograph system and air-tight sealing assembly therefor
patent, May 1994


Whole-body plethysmograph
patent, October 1997


Plethysmograph
patent, September 2000


Method and apparatus for noninvasive determination of peripheral arterial lumenal area
patent, October 2001


Plethysmograph pulse recognition processor
patent, October 2002


Vascular endothelial cell function evaluating apparatus
patent, April 2004


Plethysmograph pulse recognition processor
patent, November 2004


Reduced-noise plethysmograph
patent, June 2005


Method of measuring endothelial function in a person
patent, June 2005


Method and apparatus for non-invasively evaluating endothelial activity in a patient
patent, September 2005


Method and system utilizing SpO2 plethysmograph signal to qualify NIBP pulses
patent, November 2007


Adjustable table plethysmograph
patent, July 2008


Method and system utilizing SpO2 plethysmograph signal to reduce NIBP determination time
patent, December 2008


Apparatus and method of evaluating vascular endothelial function
patent, September 2014


Apparatus for evaluating vascular endothelial function
patent, October 2015


Apparatus for evaluating vascular endothelial function
patent, September 2016


Method and system for detecting vascular conditions using an occlusive arm cuff plethysmograph
patent-application, August 2002


Superior-and -inferior-limb blood-pressure index measuring apparatus
patent-application, September 2002


Seal for Use in a Volume Displacement Plethysmograph
patent-application, September 2002


Plethysmograph pulse recognition processor
patent-application, February 2003


Calibrated measurement of blood vessels and endothelium after reactive hyperemia and method therefor
patent-application, April 2003


Reduced-noise plethysmograph
patent-application, December 2004


Assessment of vascular dilatation
patent-application, March 2005


Plethysmograph pulse recognition processor
patent-application, April 2005


Method and an apparatus for pulse plethysmograph based detection of nociception during anaesthesia or sedation
patent-application, June 2005


Method and apparatus for examining vascular endothelial functions
patent-application, October 2005


Adjustable table plethysmograph
patent-application, November 2005


Plethysmograph pulse recognition processor
patent-application, September 2006


Method and apparatus for assessing vascular endothelial function
patent-application, November 2006


Arterial endothelial function measurement method and apparatus
patent-application, November 2006


Auto-inflation cuffs
patent-application, May 2007


Large diameter plethysmograph
patent-application, August 2007


Method and Apparatus for Comprehensive Assessment of Vascular Health
patent-application, September 2007


Method and Apparatus for Determining Vascular Health Conditions
patent-application, September 2007


Wrist plethysmograph
patent-application, December 2007


Risk Assessment Method for Acute Cardiovascular Events
patent-application, January 2008


Method and System of Determining NIBP Target Inflation Pressure Using an SP02 Plethysmograph Signal
patent-application, February 2008


Methods and Apparatus for Profiling Cardiovascular Vulnerability to Mental Stress
patent-application, April 2008


Method and System Utilizing SpO2 Plethysmograph Signal to Reduce NIBP Determination Time
patent-application, April 2008


Method and Apparatus for Automated Vascular Function Testing
patent-application, May 2008


Plethysmograph Variability Processor
patent-application, August 2008


Method and Apparatus for Determining Vascular Health Conditions
patent-application, October 2008


Non-Invasive Blood Pressure Determination Method
patent-application, October 2008


Acoustic Plethysmograph for Measuring Pulmonary Function
patent-application, January 2009


Apparatus and Method of Evaluating Vascular Endothelial Function
patent-application, October 2009


Cardiovascular Health Station Methods and Apparatus
patent-application, April 2010


System and method of measuring changes in arterial volume of a limb segment
patent-application, November 2010


Method and Device for Detecting and Assessing Reactive Hyperemia Using Segmental Plethysmography
patent-application, December 2010


Apparatus for Evaluating Vascular Endothelial Function
patent-application, March 2011


Systems and Methods for Normalizing a Plethysmograph Signal for Improved Feature Analysis
patent-application, March 2011


Blood Pressure Measurement Apparatus and Blood Pressure Measurement Method
patent-application, June 2013


Systems For Replicating The Beneficial Effects Of Physical Exercise And Improving Cardiovascular Health
patent-application, April 2014


Assessing Endothelial Function Using a Blood Pressure Cuff
patent-application, May 2014


Method and Device for Detecting and Assessing Reactive Hyperemia Using Segmental Plethysmography
patent-application, September 2014


Assessing Endothelial Function Using a Blood Pressure Cuff
patent-application, December 2015


Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
journal, January 2010

  • Axtell, Andrea L.; Gomari, Fatemeh A.; Cooke, John P.
  • Journal of Visualized Experiments, Vol. 44, Article No. e2167
  • https://doi.org/10.3791/2167

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
journal, November 1992


Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds
journal, January 2005


Cross-Sectional Relations of Digital Vascular Function to Cardiovascular Risk Factors in the Framingham Heart Study
journal, May 2008


Assessment of Endothelial Function in the Radial Artery Using Inhaled Albuterol
conference, August 2007


Noninvasive Low-Frequency Ultrasound Energy Causes Vasodilation in Humans
journal, August 2006


Endothelial Function: Cardiac Events
journal, January 2005


Radial Artery Compliance in Young, Obese, Normotensive Subjects
journal, December 1995


Role of nitric oxide in the regulation of digital pulse volume amplitude in humans
journal, August 2006


Endothelium-dependent flow-mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease
journal, December 1998


Novel non-invasive method of measurement of endothelial function: enclosed-zone flow-mediated dilatation (ezFMD)
journal, September 2012