Title: Assessing endothelial function and providing calibrated UFMD data using a blood pressure cuff

Abstract

Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve using a cuff to apply pressure to an artery in a subject to determine a plurality of baseline values for a parameter related to endothelial function as a function of applied pressure (P.sub.m); b) applying a stimulus to the subject; and applying external pressure P.sub.m to the artery to determine a plurality of stimulus-effected values for the parameter related to endothelial function as a function of applied pressure (P.sub.m); where the baseline values are determined from measurements made when said mammal is not substantially effected by said stimulus and differences in said baseline values and said stimulus-effected values provide a measure of endothelial function in said mammal.

Inventors:

Maltz, Jonathan S.

Issue Date:

Tue Jul 24 00:00:00 EDT 2018

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1464470

Patent Number(s):

10028664

Application Number:

15/680,082

Assignee:

The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16H - HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A61B17/1355 - {Automated control means therefor}
A61B5/02021 - {Determining capillary fragility}
A61B5/02116 - {of pulse wave amplitude
A61B5/02208 - {using the Korotkoff method}
A61B5/02225 - {using the oscillometric method}
A61B5/02233 - {Occluders specially adapted therefor
A61B5/0225 - the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
A61B5/1075 - {for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer
A61B5/7225 - {Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
A61B5/7278 - {Artificial waveform generation or derivation, e.g. synthesising signals from measured signals
A61B8/04 - Measuring blood pressure
A61B8/06 - Measuring blood flow
A61B8/5223 - {for extracting a diagnostic or physiological parameter from medical diagnostic data
A61B8/58 - {Testing, adjusting or calibrating the diagnostic device}

G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16H - HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

G16H50/30 - for calculating health indices

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02A - TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

Y02A90/10 - Information and communication technologies [ICT] supporting adaptation to climate change.

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DOE Contract Number:  

AC02-05CH11231

Resource Type:

Patent

Resource Relation:

Patent File Date: 2017 Aug 17

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES