DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.

Abstract

Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.

Inventors:
 [1];  [2];  [3];  [4]
  1. Brookline, MA
  2. Chagrin Falls, OH
  3. Cambridge, MA
  4. Durham, NC
Issue Date:
Research Org.:
Harvard University
Sponsoring Org.:
USDOE
OSTI Identifier:
984521
Patent Number(s):
7425431
Application Number:
11/505,073
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FG02-02ER63445
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Church, George M, Shendure, Jay, Porreca, Gregory J, and Zhu, Jun. Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.. United States: N. p., 2008. Web.
Church, George M, Shendure, Jay, Porreca, Gregory J, & Zhu, Jun. Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.. United States.
Church, George M, Shendure, Jay, Porreca, Gregory J, and Zhu, Jun. Tue . "Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.". United States. https://www.osti.gov/servlets/purl/984521.
@article{osti_984521,
title = {Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.},
author = {Church, George M and Shendure, Jay and Porreca, Gregory J and Zhu, Jun},
abstractNote = {Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {9}
}

Works referenced in this record:

Cap analysis gene expression for high-throughput analysis of transcriptional starting point and identification of promoter usage
journal, December 2003


Gene expression analysis of plant host-pathogen interactions by SuperSAGE
journal, December 2003


Sandwich hybridization as a convenient method for the detection of nucleic acids in crude samples
journal, January 1983


Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries
journal, April 1994


Advanced sequencing technologies: methods and goals
journal, May 2004


Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library
journal, August 1994


Digital quantitative measurements of gene expression
journal, January 2004


Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists
journal, November 1996


Rapid shotgeun cloning utillizing the two base recongition endonuclease Cvi JI
journal, January 1992


UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement.
journal, January 1994


Mechanism of formation of two-dimensional crystals from latex particles on substrates
journal, December 1992


A versatile solid support system for oligodeoxynucleotide probe-based hybridization assays
journal, January 1991


A Novel Procedure for the Synthesis of Libraries Containing Small Organic Molecules
journal, November 1994


Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays
journal, June 2000


Affinity chromatography of a sequence-specific DNA binding protein using teflon-linked oligonucleotides
journal, February 1988


An Artificial Gene for Human Porphobilinogen Synthase Allows Comparison of an Allelic Variation Implicated in Susceptibility to Lead Poisoning
journal, January 2000


Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication.
journal, March 1990


Use of statistical criteria for screening potential homologies in nucleic acid sequences
journal, January 1984


Serial Analysis of Gene Expression
journal, October 1995


Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations
journal, July 2003


Using the transcriptome to annotate the genome
journal, May 2002


"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.
journal, August 1993


A Solution-Phase Screening Procedure for the Isolation of Active Compounds from a Library of Molecules
journal, November 1994


Digital genotyping and haplotyping with polymerase colonies
journal, May 2003


Use of DNA immobilized on plastic and agarose supports to detect DNA by sandwich hybridization.
journal, September 1985


Rapid hybridization kinetics of DNA attached to submkron latex particles
journal, January 1987


Transcription-based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format.
journal, February 1989


Synthesis of deoxyoligonucleotides on a polymer support
journal, June 1981


Synthesis of deoxyoligonucleotides on a polymer support
journal, June 1981


Fluorescent in situ sequencing on polymerase colonies
journal, September 2003


Expression profiling using cDNA microarrays
journal, January 1999


Exponential Amplification of Recombinant- RNA Hybridization Probes
journal, October 1988


Gene2Oligo: oligonucleotide design for in vitro gene synthesis
journal, July 2004


A rapid method of gene detection using DNA bound to Sephacryl
journal, January 1985


In Vivo Protein Cyclization Promoted by a Circularly Permuted Synechocystis sp. PCC6803 DnaB Mini-intein
journal, December 2001


Recursive deconvolution of combinatorial chemical libraries.
journal, November 1994


A ligase-mediated gene detection technique
journal, August 1988


Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome
journal, September 2005