Title: Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.

Abstract

Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.

Inventors:

Church, George M ^[1]; Shendure, Jay ^[2]; Porreca, Gregory J ^[3]; Zhu, Jun ^[4]

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+ Show Inventor Affiliations

1. Brookline, MA
2. Chagrin Falls, OH
3. Cambridge, MA
4. Durham, NC

Issue Date:

2008-09-16

Research Org.:

Harvard University

Sponsoring Org.:

USDOE

OSTI Identifier:

984521

Patent Number(s):

7425431

Application Number:

11/505,073

Assignee:

President and Fellows of Harvard College (Cambridge, MA)

Patent Classifications (CPCs):

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N15/1093 - {General methods of preparing gene libraries, not provided for in other subgroups}

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase
C12Q1/6874 - involving nucleic acid arrays, e.g. sequencing by hybridisation
C12Q2537/143 - Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
C12Q2563/149 - Particles, e.g. beads
C12Q2565/537 - characterised by the capture oligonucleotide acting as a primer
C12Q2565/601 - being a microscope, e.g. atomic force microscopy [AFM]

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DOE Contract Number:  

FG02-02ER63445

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

47 OTHER INSTRUMENTATION