DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Assessing endothelial function using a blood pressure cuff

Abstract

Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve applying to the artery a substantially constant external pressure that causes the tension in the arterial wall to be reduced, where the pressure is provided via a cuff adjacent to and/or around a region of the mammal's body; determining, over the course of one or more cardiac cycles, changes in pressure in the cuff resulting from cardiac activity of the mammal to establish a baseline value for a parameter related to endothelial function in the mammal; applying a stimulus to the mammal; determining, over the course of one or more cardiac cycles, changes in pressure in the cuff resulting from cardiac activity of the mammal to establish a stimulus-effected value for a parameter related to endothelial function in the mammal; wherein the baseline value is determined from measurements made when the mammal is not substantially effected by the stimulus; and wherein differences in the baseline value and the stimulus-effected value provide a measure of endothelial function in the mammal.

Inventors:
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1805621
Patent Number(s):
10945612
Application Number:
14/678,642
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 04/03/2015
Country of Publication:
United States
Language:
English

Citation Formats

Maltz, Jonathan S. Assessing endothelial function using a blood pressure cuff. United States: N. p., 2021. Web.
Maltz, Jonathan S. Assessing endothelial function using a blood pressure cuff. United States.
Maltz, Jonathan S. Tue . "Assessing endothelial function using a blood pressure cuff". United States. https://www.osti.gov/servlets/purl/1805621.
@article{osti_1805621,
title = {Assessing endothelial function using a blood pressure cuff},
author = {Maltz, Jonathan S.},
abstractNote = {Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve applying to the artery a substantially constant external pressure that causes the tension in the arterial wall to be reduced, where the pressure is provided via a cuff adjacent to and/or around a region of the mammal's body; determining, over the course of one or more cardiac cycles, changes in pressure in the cuff resulting from cardiac activity of the mammal to establish a baseline value for a parameter related to endothelial function in the mammal; applying a stimulus to the mammal; determining, over the course of one or more cardiac cycles, changes in pressure in the cuff resulting from cardiac activity of the mammal to establish a stimulus-effected value for a parameter related to endothelial function in the mammal; wherein the baseline value is determined from measurements made when the mammal is not substantially effected by the stimulus; and wherein differences in the baseline value and the stimulus-effected value provide a measure of endothelial function in the mammal.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {3}
}

Works referenced in this record:

Method and apparatus for non-invasively evaluating endothelial activity in a patient
patent, September 2005


Ocular plethysmograph
patent, February 1979


Method and system utilizing SpO2 plethysmograph signal to qualify NIBP pulses
patent, November 2007


Impedance plethysmograph
patent, September 1979


Method and system for detecting vascular conditions using an occlusive arm cuff plethysmograph
patent, September 2003


Reduced-noise plethysmograph
patent, June 2005


Peripheral arterial monitoring instruments
patent, May 1995


Apparatus and method for vascular examination of a limb
patent, February 1992


Computer assisted admittance plethysmograph
patent, October 1985


Eye fundus plethysmograph assembly
patent, June 1979


Method and apparatus for noninvasive determination of peripheral arterial lumenal area
patent, October 2001


Method and system utilizing SpO2 plethysmograph signal to reduce NIBP determination time
patent, December 2008


Apparatus for evaluating vascular endothelial function
patent, October 2015


Method and an apparatus for pulse plethysmograph based detection of nociception during anesthesia or sedation
patent, August 2008


Method of measuring endothelial function in a person
patent, June 2005


Ultrasonic plethysmograph
patent, March 1994


Plethysmograph cuff bladder
patent, June 1986


Tourniquet for regulating applied pressures
patent, September 1991


Plethysmograph pressure correcting arrangement
patent, April 1985


Strain gauge plethysmograph
patent, March 1981


Ultrasonic plethysmograph
patent, February 1993


Plethysmograph pulse recognition processor
patent, October 2002


Whole-body plethysmograph
patent, October 1997


Garment for impedance plethysmograph use
patent, April 1977


Plethysmograph pulse recognition processor
patent, November 2004


Plethysmograph system and air-tight sealing assembly therefor
patent, May 1994


Assessment of vascular dilatation
patent, June 2008


Method and system of determining NIBP target inflation pressure using an SpO2 plethysmograph signal
patent, June 2008


Apparatus and method of evaluating vascular endothelial function
patent, September 2014


Apparatus for evaluating vascular endothelial function
patent, September 2016


Plethysmograph
patent, September 2000


Adjustable table plethysmograph
patent, July 2008


Method of measuring blood pressure with a plethysmograph
patent, December 1993


Adaptive pneumatic tourniquet
patent, October 1984


Ultrasonic plethysmograph
patent, February 1992


Vascular endothelial cell function evaluating apparatus
patent, April 2004


Seal for use in a volume displacement plethysmograph
patent, November 2002