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Title: Assessing endothelial function using a blood pressure cuff

Abstract

Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve applying to the artery a substantially constant external pressure that causes the tension in the arterial wall to be reduced, where the pressure is provided via a cuff adjacent to and/or around a region of the mammal's body; determining, over the course of one or more cardiac cycles, changes in pressure in the cuff resulting from cardiac activity of the mammal to establish a baseline value for a parameter related to endothelial function in the mammal; applying a stimulus to the mammal; determining, over the course of one or more cardiac cycles, changes in pressure in the cuff resulting from cardiac activity of the mammal to establish a stimulus-effected value for a parameter related to endothelial function in the mammal; wherein the baseline value is determined from measurements made when the mammal is not substantially effected by the stimulus; and wherein differences in the baseline value and the stimulus-effected value provide a measure of endothelial function in the mammal.

Inventors:
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1805621
Patent Number(s):
10945612
Application Number:
14/678,642
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 04/03/2015
Country of Publication:
United States
Language:
English

Citation Formats

Maltz, Jonathan S. Assessing endothelial function using a blood pressure cuff. United States: N. p., 2021. Web.
Maltz, Jonathan S. Assessing endothelial function using a blood pressure cuff. United States.
Maltz, Jonathan S. Tue . "Assessing endothelial function using a blood pressure cuff". United States. https://www.osti.gov/servlets/purl/1805621.
@article{osti_1805621,
title = {Assessing endothelial function using a blood pressure cuff},
author = {Maltz, Jonathan S.},
abstractNote = {Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve applying to the artery a substantially constant external pressure that causes the tension in the arterial wall to be reduced, where the pressure is provided via a cuff adjacent to and/or around a region of the mammal's body; determining, over the course of one or more cardiac cycles, changes in pressure in the cuff resulting from cardiac activity of the mammal to establish a baseline value for a parameter related to endothelial function in the mammal; applying a stimulus to the mammal; determining, over the course of one or more cardiac cycles, changes in pressure in the cuff resulting from cardiac activity of the mammal to establish a stimulus-effected value for a parameter related to endothelial function in the mammal; wherein the baseline value is determined from measurements made when the mammal is not substantially effected by the stimulus; and wherein differences in the baseline value and the stimulus-effected value provide a measure of endothelial function in the mammal.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {3}
}

Works referenced in this record:

Seal for Use in a Volume Displacement Plethysmograph
patent-application, September 2002


Plethysmograph Variability Processor
patent-application, August 2008


Method and apparatus for non-invasively evaluating endothelial activity in a patient
patent, September 2005


Ocular plethysmograph
patent, February 1979


Method and system utilizing SpO2 plethysmograph signal to qualify NIBP pulses
patent, November 2007


Non-Invasive Blood Pressure Determination Method
patent-application, October 2008


Impedance plethysmograph
patent, September 1979


Reduced-noise plethysmograph
patent, June 2005


Method and Apparatus for Determining Vascular Health Conditions
patent-application, September 2007


Apparatus and method for vascular examination of a limb
patent, February 1992


Assessing Endothelial Function Using a Blood Pressure Cuff
patent-application, May 2014


Adjustable table plethysmograph
patent-application, November 2005


Method and Apparatus for Determining Vascular Health Conditions
patent-application, October 2008


Method and apparatus for noninvasive determination of peripheral arterial lumenal area
patent, October 2001


Assessment of vascular dilatation
patent-application, March 2005


Method and Apparatus for Automated Vascular Function Testing
patent-application, May 2008


Plethysmograph pulse recognition processor
patent-application, February 2003


Method and Apparatus for Comprehensive Assessment of Vascular Health
patent-application, September 2007


Cardiovascular Health Station Methods and Apparatus
patent-application, April 2010


Arterial endothelial function measurement method and apparatus
patent-application, November 2006


Method and system for detecting vascular conditions using an occlusive arm cuff plethysmograph
patent-application, August 2002


Non-Invasive Electronic Method and Apparatus for Measuring Blood Pressure
patent-application, May 2009


Method and System Utilizing SpO2 Plethysmograph Signal to Reduce NIBP Determination Time
patent-application, April 2008


Method and system utilizing SpO2 plethysmograph signal to reduce NIBP determination time
patent, December 2008


Blood Pressure Measurement Apparatus and Blood Pressure Measurement Method
patent-application, June 2013


Systems For Replicating The Beneficial Effects Of Physical Exercise And Improving Cardiovascular Health
patent-application, April 2014


Methods and Apparatus for Profiling Cardiovascular Vulnerability to Mental Stress
patent-application, April 2008


Method and apparatus for assessing vascular endothelial function
patent-application, November 2006


Plethysmograph pulse recognition processor
patent-application, September 2006


Apparatus for evaluating vascular endothelial function
patent, October 2015


Method and apparatus for examining vascular endothelial functions
patent-application, October 2005


Calibrated measurement of blood vessels and endothelium after reactive hyperemia and method therefor
patent-application, April 2003


Systems and Methods for Normalizing a Plethysmograph Signal for Improved Feature Analysis
patent-application, March 2011


Apparatus and Method of Evaluating Vascular Endothelial Function
patent-application, October 2009


Method of measuring endothelial function in a person
patent, June 2005


Ultrasonic plethysmograph
patent, March 1994


Plethysmograph cuff bladder
patent, June 1986


Tourniquet for regulating applied pressures
patent, September 1991


Apparatus for Evaluating Vascular Endothelial Function
patent-application, March 2011


System and method of measuring changes in arterial volume of a limb segment
patent-application, November 2010


Strain gauge plethysmograph
patent, March 1981


Ultrasonic plethysmograph
patent, February 1993


Plethysmograph pulse recognition processor
patent, October 2002


Whole-body plethysmograph
patent, October 1997


Plethysmograph pulse recognition processor
patent, November 2004


System for measuring and analyzing vasodilatation index
patent-application, December 2004


Plethysmograph system and air-tight sealing assembly therefor
patent, May 1994


Large diameter plethysmograph
patent-application, August 2007


Reduced-noise plethysmograph
patent-application, December 2004


Method and System of Determining NIBP Target Inflation Pressure Using an SP02 Plethysmograph Signal
patent-application, February 2008


Plethysmograph pulse recognition processor
patent-application, April 2005


Apparatus and method of evaluating vascular endothelial function
patent, September 2014


Apparatus for evaluating vascular endothelial function
patent, September 2016


Method and an apparatus for pulse plethysmograph based detection of nociception during anaesthesia or sedation
patent-application, June 2005


Plethysmograph
patent, September 2000


Adjustable table plethysmograph
patent, July 2008


Method of measuring blood pressure with a plethysmograph
patent, December 1993


Auto-inflation cuffs
patent-application, May 2007


Risk Assessment Method for Acute Cardiovascular Events
patent-application, January 2008


Adaptive pneumatic tourniquet
patent, October 1984


Ultrasonic plethysmograph
patent, February 1992


Method and Device for Detecting and Assessing Reactive Hyperemia Using Segmental Plethysmography
patent-application, December 2010


Wrist plethysmograph
patent-application, December 2007


Superior-and -inferior-limb blood-pressure index measuring apparatus
patent-application, September 2002


Method and Device for Detecting and Assessing Reactive Hyperemia Using Segmental Plethysmography
patent-application, September 2014


Acoustic Plethysmograph for Measuring Pulmonary Function
patent-application, January 2009


Vascular endothelial cell function evaluating apparatus
patent, April 2004