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Title: Arterial endothelial function measurement method and apparatus

A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.
Inventors:
;
Issue Date:
OSTI Identifier:
1126883
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
Patent Number(s):
8,666,472
Application Number:
11/362,326
Contract Number:
AC02-05CH11231
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Works referenced in this record:

Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction
journal, November 1994
  • Celermajer, David S.; Sorensen, Keld E.; Bull, Catherine
  • Journal of the American College of Cardiology, Vol. 24, Issue 6, p. 1468-1474
  • DOI: 10.1016/0735-1097(94)90141-4

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
journal, November 1992

Impaired endothelial function following a meal rich in used cooking fat
journal, March 1999
  • Williams, Michael J. A.; Sutherland, Wayne H. F.; McCormick, Maree P.
  • Journal of the American College of Cardiology, Vol. 33, Issue 4, p. 1050-1055
  • DOI: 10.1016/S0735-1097(98)00681-0