Arterial endothelial function measurement method and apparatus

Maltz, Jonathan S; Budinger, Thomas F

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Title: Arterial endothelial function measurement method and apparatus

Abstract

A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.

Inventors:: Maltz, Jonathan S; Budinger, Thomas F

Issue Date:: 2014-03-04

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1126883

Patent Number(s):: 8666472

Application Number:: 11/362,326

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
A61B8/488 - {involving Doppler signals}

Show less

DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

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                    Maltz, Jonathan S, and Budinger, Thomas F. Arterial endothelial function measurement method and apparatus.  United States: N. p., 2014. 
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                    Maltz, Jonathan S, & Budinger, Thomas F. Arterial endothelial function measurement method and apparatus.  United States.

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                    Maltz, Jonathan S, and Budinger, Thomas F. Tue .  
        "Arterial endothelial function measurement method and apparatus".  United States.  https://www.osti.gov/servlets/purl/1126883.

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@article{osti_1126883,

  title        = {Arterial endothelial function measurement method and apparatus},

  author       = {Maltz, Jonathan S and Budinger, Thomas F},

  abstractNote = {A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2014},

  month        = {3}

}

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