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Title: Arterial endothelial function measurement method and apparatus

Abstract

A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.

Inventors:
;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1126883
Patent Number(s):
8,666,472
Application Number:
11/362,326
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Maltz, Jonathan S, and Budinger, Thomas F. Arterial endothelial function measurement method and apparatus. United States: N. p., 2014. Web.
Maltz, Jonathan S, & Budinger, Thomas F. Arterial endothelial function measurement method and apparatus. United States.
Maltz, Jonathan S, and Budinger, Thomas F. Tue . "Arterial endothelial function measurement method and apparatus". United States. https://www.osti.gov/servlets/purl/1126883.
@article{osti_1126883,
title = {Arterial endothelial function measurement method and apparatus},
author = {Maltz, Jonathan S and Budinger, Thomas F},
abstractNote = {A "relaxoscope" (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxation. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {3}
}

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Works referenced in this record:

Dispersion and Attenuation of Small Artificial Pressure Waves in the Canine Aorta
journal, October 1968

  • Anliker, Max; Histand, Michael B.; Ogden, Eric
  • Circulation Research, Vol. 23, Issue 4
  • DOI: 10.1161/01.RES.23.4.539

Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction
journal, November 1994

  • Celermajer, David S.; Sorensen, Keld E.; Bull, Catherine
  • Journal of the American College of Cardiology, Vol. 24, Issue 6, p. 1468-1474
  • DOI: 10.1016/0735-1097(94)90141-4

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
journal, November 1992


Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.
journal, September 1989


Replacement of Dietary Saturated Fatty Acids by Trans Fatty Acids Lowers Serum HDL Cholesterol and Impairs Endothelial Function in Healthy Men and Women
journal, July 2001

  • de Roos, Nicole M.; Bots, Michiel L.; Katan, Martijn B.
  • Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 21, Issue 7
  • DOI: 10.1161/hq0701.092161

Reproducibility of brachial ultrasonography and flow-mediated dilatation (FMD) for assessing endothelial function
journal, December 1997


A Method Using Induced Waves to Study Pressure Propagation in Human Arteries
journal, November 1957


The Role of Duplex Scanning in the Selection of Patients with Critical Lower-Limb Ischemia for Infrainguinal Percutaneous Transluminal Angioplasty
journal, July 2001

  • Löfberg, Anne-Marie; Karacagil, Sadettin; Hellberg, Anders
  • CardioVascular and Interventional Radiology, Vol. 24, Issue 4
  • DOI: 10.1007/s00270-001-1786-7

Validation of a device to measure arterial pulse wave velocity by a photoplethysmographic method
journal, July 2002

  • Loukogeorgakis, Stavros; Dawson, Rex; Phillips, Nirree
  • Physiological Measurement, Vol. 23, Issue 3
  • DOI: 10.1088/0967-3334/23/3/309

Instrument for the noninvasive evaluation of human arterial endothelial function via measurement of changes in the transit time of an artificial pulse
conference, January 2003

  • Maltz, J. S.; Budinger, T. F.
  • Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)
  • DOI: 10.1109/IEMBS.2003.1280806

Early evidence of endothelial vasodilator dysfunction at coronary branch points.
journal, October 1990


The pathogenesis of atherosclerosis: a perspective for the 1990s
journal, April 1993


Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level.
journal, January 1994

  • Sorensen, K. E.; Celermajer, D. S.; Georgakopoulos, D.
  • Journal of Clinical Investigation, Vol. 93, Issue 1
  • DOI: 10.1172/JCI116983

Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility.
journal, September 1995

  • Sorensen, K. E.; Celermajer, D. S.; Spiegelhalter, D. J.
  • Heart, Vol. 74, Issue 3
  • DOI: 10.1136/hrt.74.3.247

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.
journal, February 1990


Impaired endothelial function following a meal rich in used cooking fat
journal, March 1999

  • Williams, Michael J. A.; Sutherland, Wayne H. F.; McCormick, Maree P.
  • Journal of the American College of Cardiology, Vol. 33, Issue 4, p. 1050-1055
  • DOI: 10.1016/S0735-1097(98)00681-0

Duplex ultrasound scanning versus computed tomographic angiography for postoperative evaluation of endovascular abdominal aortic aneurysm repair
journal, December 2000

  • Wolf, Yehuda G.; Johnson, Bonnie L.; Hill, Bradley B.
  • Journal of Vascular Surgery, Vol. 32, Issue 6
  • DOI: 10.1067/mva.2000.109210