Sample preparation system for microfluidic applications
Abstract
An apparatus that couples automated injection with flow feedback to provide nanoliter accuracy in controlling microliter volumes. The apparatus comprises generally a source of hydraulic fluid pressure, a fluid isolator joined to the outlet of the hydraulic pressure source and a flow sensor to provide pressure-driven analyte metering. For operation generally and particularly in microfluidic systems the hydraulic pressure source is typically an electrokinetic (EK) pump that incorporates gasless electrodes. The apparatus is capable of metering sub-microliter volumes at flowrates of 1 100 .mu.L/min into microsystem load pressures of up to 1000 50 psi, respectively. Flowrates can be specified within 0.5 .mu.L/min and volumes as small as 80 nL can be metered.
- Inventors:
-
- San Francisco, CA
- Fremont, CA
- Dublin, CA
- Livermore, CA
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-CA), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 909334
- Patent Number(s):
- 7213473
- Application Number:
- 11/016,310
- Assignee:
- Sandia National Laboratories (Livermore, CA)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
F - MECHANICAL ENGINEERING F04 - POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS F04B - POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Mosier, Bruce P, Crocker, Robert W, Patel, Kamlesh D, and Harnett, Cindy K. Sample preparation system for microfluidic applications. United States: N. p., 2007.
Web.
Mosier, Bruce P, Crocker, Robert W, Patel, Kamlesh D, & Harnett, Cindy K. Sample preparation system for microfluidic applications. United States.
Mosier, Bruce P, Crocker, Robert W, Patel, Kamlesh D, and Harnett, Cindy K. Tue .
"Sample preparation system for microfluidic applications". United States. https://www.osti.gov/servlets/purl/909334.
@article{osti_909334,
title = {Sample preparation system for microfluidic applications},
author = {Mosier, Bruce P and Crocker, Robert W and Patel, Kamlesh D and Harnett, Cindy K},
abstractNote = {An apparatus that couples automated injection with flow feedback to provide nanoliter accuracy in controlling microliter volumes. The apparatus comprises generally a source of hydraulic fluid pressure, a fluid isolator joined to the outlet of the hydraulic pressure source and a flow sensor to provide pressure-driven analyte metering. For operation generally and particularly in microfluidic systems the hydraulic pressure source is typically an electrokinetic (EK) pump that incorporates gasless electrodes. The apparatus is capable of metering sub-microliter volumes at flowrates of 1 100 .mu.L/min into microsystem load pressures of up to 1000 50 psi, respectively. Flowrates can be specified within 0.5 .mu.L/min and volumes as small as 80 nL can be metered.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 08 00:00:00 EDT 2007},
month = {Tue May 08 00:00:00 EDT 2007}
}