Microfluidic systems, pumps, valves, fluidic chips thereof, and applications of same

Patent · Tue Jan 31 00:00:00 EST 2023

OSTI ID:1987094

Reiserer, Ronald S.; Schaffer, David K.; Samson, Philip C.; Markov, Dmitry A.; Geuy, Michael; McCawley, Lisa J.; Wikswo, John P.

Microfluidic systems, pumps, valves and applications of the same are provided. The microfluidic system may be a pump or a valve having a fluidic chip and an actuator controlling the opening and closing of the fluidic channel in the fluidic chip. The actuator may be disposed to tilt from the fluidic chip, forming a tilted-rotor peristaltic pump. Alternatively, the actuator may be a rolling ball actuator, and different fluidic chips may be used in different applications. For example, the fluidic chip may be a spiral pump chip having spiral channels, a rotary peristaltic pump chip having multiple output channels, or a multi-port valve chip having one port interconnected with multiple different ports. An analytical valve chip may switchably interconnect bioreactor and rinse/calibration input channels to sensor and waste output channels. The actuator of a random-access valve can move from one valve position to another without opening or closing intermediate ones.

• Research Organization: Vanderbilt Univ., Nashville, TN (United States)
• Sponsoring Organization: USDOE; National Institutes of Health (NIH); US Environmental Protection Agency (EPA); Intelligence Advanced Research Projects Activity; Defense Threat Reduction Agency (DTRA)
• DOE Contract Number: 468746; 5UG3TR002097-02; 83573601; CBMXCEL-XL1-2-001; HHSN44C; U01CA202229
• Assignee: Vanderbilt University (Nashville, TN)
• Patent Number(s): 11,565,256
• Application Number: 17/623,350
• OSTI ID: 1987094
• Resource Relation: Patent File Date: 06/29/2020
• Country of Publication: United States
• Language: English