Title: Acceleration Of Wound Healing Ny Photodynamic Therapy

Abstract

Disclosed is a method for accelerating wound healing in a mammal. The method includes identifying an unhealed wound site or partially-healed wound site in a mammal; administering a photosensitizer to the mammal; waiting for a time period wherein the photosensitizer reaches an effective tissue concentration at the wound site; and photoactivating the photosensitizer at the wound site. The dose of photodynamic therapy is selected to stimulate the production of one or more growth factor by cells at the wound site, without causing tissue destruction.

Inventors:

Hasan, Tayyaba ^[1]; Hamblin, Michael R ^[2]; Trauner, Kenneth ^[3]

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+ Show Inventor Affiliations

1. Arlington, MA
2. Revere, MA
3. Sacramento, CA

Issue Date:

Tue Aug 22 00:00:00 EDT 2000

Research Org.:

Massachusetts General Hospital

OSTI Identifier:

879214

Patent Number(s):

6107466

Application Number:

08/160528

Assignee:

The General Hospital Corporation (Boston, MA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A61B17/00 - Surgical instruments, devices or methods, e.g. tourniquets

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K41/0071 - {PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY

A61N5/062 - {Photodynamic therapy, i.e. excitation of an agent}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P17/02 - for treating wounds, ulcers, burns, scars, keloids, or the like

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S977/932 - for electronic or optoelectronic application

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DOE Contract Number:  

FG02-91ER61228

Resource Type:

Patent

Country of Publication:

United States

Language:

English