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Title: Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.
Inventors:
Issue Date:
OSTI Identifier:
1163204
Assignee:
UT-Battelle, LLC (Oak Ridge, TN) ORNL
Patent Number(s):
8,877,176
Application Number:
13/029,189
Contract Number:
AC05-00OR22725
Resource Relation:
Patent File Date: 2011 Feb 17
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Other works cited in this record:

Nell-1 induced bone formation within the distracted intermaxillary suture
journal, January 2006

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies
journal, May 2009
  • Hentze, Hannes; Soong, Poh Loong; Wang, Siew Tein
  • Stem Cell Research, Vol. 2, Issue 3, p. 198-210
  • DOI: 10.1016/j.scr.2009.02.002

A new function of Nell-1 protein in repressing adipogenic differentiation
journal, July 2011
  • James, Aaron W.; Pan, Angel; Chiang, Michael
  • Biochemical and Biophysical Research Communications, Vol. 411, Issue 1, p. 126-131
  • DOI: 10.1016/j.bbrc.2011.06.111

Coagulation dysregulation as a barrier to xenotransplantation in the primate
journal, June 2009
  • Lin, Chih Che; Cooper, David K. C.; Dorling, Anthony
  • Transplant Immunology, Vol. 21, Issue 2, p. 75-80
  • DOI: 10.1016/j.trim.2008.10.008

The osteoinductive properties of Nell-1 in a rat spinal fusion model
journal, January 2007

The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals
journal, December 1998

Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15
journal, January 2002
  • Rinchik, E. M.; Carpenter, D. A.; Johnson, D. K.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 2, p. 844-849
  • DOI: 10.1073/pnas.022628199

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