Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1
Abstract
The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.
- Inventors:
-
- Oak Ridge, TN
- Issue Date:
- Research Org.:
- UT-Battelle LLC/ORNL, Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1016346
- Patent Number(s):
- 7910542
- Application Number:
- US Patent Application 12/238,882
- Assignee:
- UT-Battelle, LLC (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1. United States: N. p., 2011.
Web.
Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1. United States.
Culiat, Cymbeline T. Tue .
"Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1". United States. https://www.osti.gov/servlets/purl/1016346.
@article{osti_1016346,
title = {Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1},
author = {Culiat, Cymbeline T},
abstractNote = {The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {3}
}
Works referenced in this record:
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects
journal, March 2006
- Desai, Jayashree; Shannon, Mark E.; Johnson, Mahlon D.
- Human Molecular Genetics, Vol. 15, Issue 8, p. 1329-1341
Regulation of bone morphogenetic proteins in early embryonic development
journal, October 2004
- Yamamoto, Yukiyo; Oelgeschläger, Michael
- Naturwissenschaften, Vol. 91, Issue 11, p. 519-534
Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats
journal, December 1996
- Watanabe, Takeshi K.; Katagiri, Toyomasa; Suzuki, Mikio
- Genomics, Vol. 38, Issue 3, p. 273-276
Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15
journal, January 2002
- Rinchik, E. M.; Carpenter, D. A.; Johnson, D. K.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 2, p. 844-849
The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals
journal, December 1998
- Pettit, Dean K.; Gombotz, Wayne R.
- Trends in Biotechnology, Vol. 16, Issue 8, p. 343-349
Cell-Based Approaches for Cardiac Repair
journal, October 2006
- Rubart, M.; Field, L. J.
- Annals of the New York Academy of Sciences, Vol. 1080, Issue 1, p. 34-48
Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts
journal, March 2007
- Cowan, Catherine M.; Jiang, Xinquan; Hsu, Tiffany
- Journal of Bone and Mineral Research, Vol. 22, Issue 6, p. 918-930
The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)
journal, June 2004
- Tsutsumi, Satoshi; Kamata, Nobuyuki; Vokes, Tamara J.
- The American Journal of Human Genetics, Vol. 74, Issue 6, p. 1255-1261
Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
journal, January 2001
- Maeda, Kenji; Matsuhashi, Sachiko; Tabuchi, Kazuo
- Neurologia medico-chirurgica, Vol. 41, Issue 12, p. 582-589
Bone marrow cells for cardiac regeneration and repair: current status and issues
journal, July 2006
- Haider, Husnain Kh
- Expert Review of Cardiovascular Therapy, Vol. 4, Issue 4, p. 557-568
Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994
- Ngo, J. Thomas; Marks, Joe; Karplus, Martin
- The Protein Folding Problem and Tertiary Structure Prediction, p. 433-506
The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage
journal, April 1999
- Luce, Milson J.; Burrows, Peter D.
- Gene, Vol. 231, Issue 1-2, p. 121-126
Nell-1 induced bone formation within the distracted intermaxillary suture
journal, January 2006
- Cowan, Catherine M.; Cheng, Samson; Ting, Kang
- Bone, Vol. 38, Issue 1, p. 48-58
Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development
journal, May 2006
- Zhang, Xinli; Cowan, Catherine M.; Jiang, Xinquan
- Laboratory Investigation, Vol. 86, Issue 7, p. 633-644
Human NELL-1 Expressed in Unilateral Coronal Synostosis
journal, January 1999
- Ting, Kang; Vastardis, Heleni; Mulliken, John B.
- Journal of Bone and Mineral Research, Vol. 14, Issue 1, p. 80-89
Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2
journal, November 1999
- Kuroda, Shun'ichi; Oyasu, Miho; Kawakami, Masakatsu
- Biochemical and Biophysical Research Communications, Vol. 265, Issue 1, p. 79-86
From cardiac repair to cardiac regeneration – ready to translate?
journal, August 2006
- Ott, Harald C.; Taylor, Doris A.
- Expert Opinion on Biological Therapy, Vol. 6, Issue 9, p. 867-878
Current Concepts In Intervertebral Disk Restoration
journal, July 2000
- Diwan, Ashish D.; Parvataneni, Hari K.; Khan, Safdar N.
- Orthopedic Clinics of North America, Vol. 31, Issue 3, p. 453-464
Growth Factor Enhancement of Cardiac Regeneration
journal, January 2006
- Rosenthal, Nadia; Santini, Maria Paola; Musarò, Antonio
- Cell Transplantation, Vol. 15, Issue S1, p. 41-45
Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C
journal, November 1999
- Kuroda, Shun'ichi; Tanizawa, Katsuyuki
- Biochemical and Biophysical Research Communications, Vol. 265, Issue 3, p. 752-757
Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
journal, December 2003
- Zhang, Xinli; Carpenter, Dale; Bokui, Nobuyuki
- Journal of Bone and Mineral Research, Vol. 18, Issue 12, p. 2126-2134
Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
journal, June 2001
- Orlic, Donald; Kajstura, Jan; Chimenti, Stefano
- Annals of the New York Academy of Sciences, Vol. 938, Issue 1, p. 221-230
BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
journal, December 2003
- Schmitt, Bernhard; Ringe, Jochen; Häupl, Thomas
- Differentiation, Vol. 71, Issue 9-10, p. 567-577
Additivity of mutational effects in proteins
journal, September 1990
- Wells, James A.
- Biochemistry, Vol. 29, Issue 37, p. 8509-8517
Nell-1-Induced Bone Regeneration in Calvarial Defects
journal, September 2006
- Aghaloo, Tara; Cowan, Catherine M.; Chou, Yu-Fen
- The American Journal of Pathology, Vol. 169, Issue 3, p. 903-915