skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1

Abstract

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

Inventors:
 [1]
  1. Oak Ridge, TN
Issue Date:
Research Org.:
UT-Battelle LLC/ORNL, Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1016346
Patent Number(s):
7910542
Application Number:
US Patent Application 12/238,882
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1. United States: N. p., 2011. Web.
Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1. United States.
Culiat, Cymbeline T. Tue . "Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1". United States. https://www.osti.gov/servlets/purl/1016346.
@article{osti_1016346,
title = {Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1},
author = {Culiat, Cymbeline T},
abstractNote = {The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {3}
}

Patent:

Save / Share:

Works referenced in this record:

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects
journal, March 2006


Regulation of bone morphogenetic proteins in early embryonic development
journal, October 2004


Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats
journal, December 1996


The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals
journal, December 1998


Cell-Based Approaches for Cardiac Repair
journal, October 2006


Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts
journal, March 2007


The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)
journal, June 2004

  • Tsutsumi, Satoshi; Kamata, Nobuyuki; Vokes, Tamara J.
  • The American Journal of Human Genetics, Vol. 74, Issue 6, p. 1255-1261
  • https://doi.org/10.1086/421527

Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
journal, January 2001


Bone marrow cells for cardiac regeneration and repair: current status and issues
journal, July 2006


Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994


Craniosynostosis in transgenic mice overexpressing Nell-1
journal, September 2002


Nell-1 induced bone formation within the distracted intermaxillary suture
journal, January 2006


Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development
journal, May 2006


Human NELL-1 Expressed in Unilateral Coronal Synostosis
journal, January 1999


Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2
journal, November 1999


From cardiac repair to cardiac regeneration – ready to translate?
journal, August 2006


Current Concepts In Intervertebral Disk Restoration
journal, July 2000


Growth Factor Enhancement of Cardiac Regeneration
journal, January 2006


Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C
journal, November 1999


Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
journal, December 2003


Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
journal, June 2001


BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
journal, December 2003


Additivity of mutational effects in proteins
journal, September 1990


Nell-1-Induced Bone Regeneration in Calvarial Defects
journal, September 2006