skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1

Abstract

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

Inventors:
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1429850
Patent Number(s):
9,920,104
Application Number:
14/495,942
Assignee:
UT-Battelle, LLC (Oak Ridge, TN) ORNL
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Sep 25
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1. United States: N. p., 2018. Web.
Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1. United States.
Culiat, Cymbeline T. Tue . "Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1". United States. https://www.osti.gov/servlets/purl/1429850.
@article{osti_1429850,
title = {Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1},
author = {Culiat, Cymbeline T.},
abstractNote = {The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {3}
}

Patent:

Save / Share:

Works referenced in this record:

Skeletal muscle injury�molecular changes in the collagen during healing
journal, March 1985

  • Lehto, M.; Sims, T. J.; Bailey, A. J.
  • Research In Experimental Medicine, Vol. 185, Issue 2, p. 95-106
  • DOI: 10.1007/BF01854894

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
journal, January 2004

  • Lecker, Stewart H.; Jagoe, R. Thomas; Gilbert, Alexander
  • The FASEB Journal, Vol. 18, Issue 1, p. 39-51
  • DOI: 10.1096/fj.03-0610com

Wound Healing--Aiming for Perfect Skin Regeneration
journal, April 1997


Effect of collagen matrices on dermal wound healing
journal, November 2003


Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies
journal, May 2009

  • Hentze, Hannes; Soong, Poh Loong; Wang, Siew Tein
  • Stem Cell Research, Vol. 2, Issue 3, p. 198-210
  • DOI: 10.1016/j.scr.2009.02.002

Quantitative Comparison of Constitutive Promoters in Human ES cells
journal, August 2010


Gene therapy for muscular dystrophy: current progress and future prospects
journal, June 2009

  • Trollet, Capucine; Athanasopoulos, Takis; Popplewell, Linda
  • Expert Opinion on Biological Therapy, Vol. 9, Issue 7, p. 849-866
  • DOI: 10.1517/14712590903029164

Ex vivo gene transfer and correction for cell-based therapies
journal, March 2011

  • Naldini, Luigi
  • Nature Reviews Genetics, Vol. 12, Issue 5, p. 301-315
  • DOI: 10.1038/nrg2985

Application ofex VivoGene Therapy in the Treatment of Parkinson's Disease
journal, March 1997

  • Raymon, H. K.; Thode, S.; Gage, F. H.
  • Experimental Neurology, Vol. 144, Issue 1, p. 82-91
  • DOI: 10.1006/exnr.1996.6392

Cells as vehicles for therapeutic genes to treat liver diseases
journal, April 2008

  • Prieto, J.; Fernandez-Ruiz, V.; Kawa, M. P.
  • Gene Therapy, Vol. 15, Issue 10, p. 765-771
  • DOI: 10.1038/gt.2008.44

Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
journal, August 2007


A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation
journal, October 2007

  • Aghaloo, Tara; Jiang, Xinquan; Soo, Chia
  • Molecular Therapy, Vol. 15, Issue 10, p. 1872-1880
  • DOI: 10.1038/sj.mt.6300270

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects
journal, March 2006

  • Desai, Jayashree; Shannon, Mark E.; Johnson, Mahlon D.
  • Human Molecular Genetics, Vol. 15, Issue 8, p. 1329-1341
  • DOI: 10.1093/hmg/ddl053

The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)
journal, June 2004

  • Tsutsumi, Satoshi; Kamata, Nobuyuki; Vokes, Tamara J.
  • The American Journal of Human Genetics, Vol. 74, Issue 6, p. 1255-1261
  • DOI: 10.1086/421527

Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development
journal, May 2006

  • Zhang, Xinli; Cowan, Catherine M.; Jiang, Xinquan
  • Laboratory Investigation, Vol. 86, Issue 7, p. 633-644
  • DOI: 10.1038/labinvest.3700430

Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
journal, December 2003

  • Zhang, Xinli; Carpenter, Dale; Bokui, Nobuyuki
  • Journal of Bone and Mineral Research, Vol. 18, Issue 12, p. 2126-2134
  • DOI: 10.1359/jbmr.2003.18.12.2126

Human NELL-1 Expressed in Unilateral Coronal Synostosis
journal, January 1999

  • Ting, Kang; Vastardis, Heleni; Mulliken, John B.
  • Journal of Bone and Mineral Research, Vol. 14, Issue 1, p. 80-89
  • DOI: 10.1359/jbmr.1999.14.1.80

Nell-1-Induced Bone Regeneration in Calvarial Defects
journal, September 2006

  • Aghaloo, Tara; Cowan, Catherine M.; Chou, Yu-Fen
  • The American Journal of Pathology, Vol. 169, Issue 3, p. 903-915
  • DOI: 10.2353/ajpath.2006.051210

Craniosynostosis in transgenic mice overexpressing Nell-1
journal, September 2002

  • Zhang, Xinli; Kuroda, Shun�ichi; Carpenter, Dale
  • Journal of Clinical Investigation, Vol. 110, Issue 6, p. 861-870
  • DOI: 10.1172/JCI15375

Nell-1 induced bone formation within the distracted intermaxillary suture
journal, January 2006


Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
journal, January 2001

  • Maeda, Kenji; Matsuhashi, Sachiko; Tabuchi, Kazuo
  • Neurologia medico-chirurgica, Vol. 41, Issue 12, p. 582-589
  • DOI: 10.2176/nmc.41.582

Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2
journal, November 1999

  • Kuroda, Shun'ichi; Oyasu, Miho; Kawakami, Masakatsu
  • Biochemical and Biophysical Research Communications, Vol. 265, Issue 1, p. 79-86
  • DOI: 10.1006/bbrc.1999.1638

Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats
journal, December 1996

  • Watanabe, Takeshi K.; Katagiri, Toyomasa; Suzuki, Mikio
  • Genomics, Vol. 38, Issue 3, p. 273-276
  • DOI: 10.1006/geno.1996.0628

Cell-Based Approaches for Cardiac Repair
journal, October 2006

  • Rubart, M.; Field, L. J.
  • Annals of the New York Academy of Sciences, Vol. 1080, Issue 1, p. 34-48
  • DOI: 10.1196/annals.1380.004

From cardiac repair to cardiac regeneration � ready to translate?
journal, August 2006

  • Ott, Harald C.; Taylor, Doris A.
  • Expert Opinion on Biological Therapy, Vol. 6, Issue 9, p. 867-878
  • DOI: 10.1517/14712598.6.9.867

Growth Factor Enhancement of Cardiac Regeneration
journal, January 2006

  • Rosenthal, Nadia; Santini, Maria Paola; Musar�, Antonio
  • Cell Transplantation, Vol. 15, Issue S1, p. 41-45
  • DOI: 10.3727/000000006783982287

Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein�Protein Interaction with Protein Kinase C
journal, November 1999

  • Kuroda, Shun'ichi; Tanizawa, Katsuyuki
  • Biochemical and Biophysical Research Communications, Vol. 265, Issue 3, p. 752-757
  • DOI: 10.1006/bbrc.1999.1753

Bone marrow cells for cardiac regeneration and repair: current status and issues
journal, July 2006


Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
journal, June 2001


The osteoinductive properties of Nell-1 in a rat spinal fusion model
journal, January 2007


Clinical xenotransplantation: the next medical revolution?
journal, February 2012


Current Concepts In Intervertebral Disk Restoration
journal, July 2000

  • Diwan, Ashish D.; Parvataneni, Hari K.; Khan, Safdar N.
  • Orthopedic Clinics of North America, Vol. 31, Issue 3, p. 453-464
  • DOI: 10.1016/S0030-5898(05)70163-2

Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15
journal, January 2002

  • Rinchik, E. M.; Carpenter, D. A.; Johnson, D. K.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 2, p. 844-849
  • DOI: 10.1073/pnas.022628199

Regulation of bone morphogenetic proteins in early embryonic development
journal, October 2004

  • Yamamoto, Yukiyo; Oelgeschl�ger, Michael
  • Naturwissenschaften, Vol. 91, Issue 11, p. 519-534
  • DOI: 10.1007/s00114-004-0575-z

Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts
journal, March 2007

  • Cowan, Catherine M.; Jiang, Xinquan; Hsu, Tiffany
  • Journal of Bone and Mineral Research, Vol. 22, Issue 6, p. 918-930
  • DOI: 10.1359/jbmr.070312

BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
journal, December 2003


The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals
journal, December 1998


Additivity of mutational effects in proteins
journal, September 1990


Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

  • Ngo, J. Thomas; Marks, Joe; Karplus, Martin
  • The Protein Folding Problem and Tertiary Structure Prediction, p. 433-506
  • DOI: 10.1007/978-1-4684-6831-1_14

Coagulation dysregulation as a barrier to xenotransplantation in the primate
journal, June 2009

  • Lin, Chih Che; Cooper, David K. C.; Dorling, Anthony
  • Transplant Immunology, Vol. 21, Issue 2, p. 75-80
  • DOI: 10.1016/j.trim.2008.10.008

Stem Cell Therapy in Perspective
journal, February 2003


Effects of Administration Route on Migration and Distribution of Neural Progenitor Cells Transplanted into Rats with Focal Cerebral Ischemia, an MRI Study
journal, November 2009

  • Li, Lian; Jiang, Quan; Ding, Guangliang
  • Journal of Cerebral Blood Flow & Metabolism, Vol. 30, Issue 3, p. 653-662
  • DOI: 10.1038/jcbfm.2009.238

A new function of Nell-1 protein in repressing adipogenic differentiation
journal, July 2011

  • James, Aaron W.; Pan, Angel; Chiang, Michael
  • Biochemical and Biophysical Research Communications, Vol. 411, Issue 1, p. 126-131
  • DOI: 10.1016/j.bbrc.2011.06.111

Biological and Biomaterial Approaches for Improved Islet Transplantation
journal, June 2006

  • Narang, Ajit S.; Mahato, Ram I.
  • Pharmacological Reviews, Vol. 58, Issue 2, p. 194-243
  • DOI: 10.1124/pr.58.2.6