Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1

Culiat, Cymbeline T.

Title: Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1

Abstract

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

Inventors:: Culiat, Cymbeline T.

Issue Date:: 2018-03-20

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1429850

Patent Number(s):: 9920104

Application Number:: 14/495,942

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/70 - Carbohydrates
A61K35/28 - Bone marrow
A61K38/00 - Medicinal preparations containing peptides
A61K38/1709 - {from mammals}
A61K38/486 - {Elastase

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P17/00 - Drugs for dermatological disorders
A61P17/02 - for treating wounds, ulcers, burns, scars, keloids, or the like
A61P19/00 - Drugs for skeletal disorders
A61P21/00 - Drugs for disorders of the muscular or neuromuscular system
A61P21/04 - for myasthenia gravis
A61P3/10 - for hyperglycaemia, e.g. antidiabetics
A61P9/00 - Drugs for disorders of the cardiovascular system

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/47 - from mammals

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DOE Contract Number:: AC05-00OR22725

Resource Type:: Patent

Resource Relation:: Patent File Date: 2014 Sep 25

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1.  United States: N. p., 2018. 
        Web.

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                    Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1.  United States.

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                    Culiat, Cymbeline T. Tue .  
        "Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1".  United States.  https://www.osti.gov/servlets/purl/1429850.

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@article{osti_1429850,

  title        = {Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1},

  author       = {Culiat, Cymbeline T.},

  abstractNote = {The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2018},

  month        = {3}

}

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Works referenced in this record:

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Title: Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1

Abstract

Citation Formats

Quantitative Comparison of Constitutive Promoters in Human ES cells journal, August 2010

Gene therapy for muscular dystrophy: current progress and future prospects journal, June 2009

Coagulation dysregulation as a barrier to xenotransplantation in the primate journal, June 2009

NELL-1 enhanced bone mineralization patent-application, October 2006

Expression system of NELL peptide patent-application, June 2007

Cell-Based Approaches for Cardiac Repair journal, October 2006

Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors journal, January 2001

Application ofex VivoGene Therapy in the Treatment of Parkinson's Disease journal, March 1997

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox book, January 1994

Adenovirus vectors encoding brain natriuretic peptide patent-application, February 2006

Effect of collagen matrices on dermal wound healing journal, November 2003

Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development journal, May 2006

Nell peptide expression systems and bone formation activity of nell peptide patent-application, December 2006

Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2 journal, November 1999

Method to Treat or Prevent a Skin Condition Using a Nell 1 Peptide patent-application, September 2011

From cardiac repair to cardiac regeneration – ready to translate? journal, August 2006

Ex vivo gene transfer and correction for cell-based therapies journal, March 2011

In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7 journal, January 2005

Current Concepts In Intervertebral Disk Restoration journal, July 2000

Growth Factor Enhancement of Cardiac Regeneration journal, January 2006

Wound Healing--Aiming for Perfect Skin Regeneration journal, April 1997

Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C journal, November 1999

Composition for cartilage patent-application, June 2007

BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture journal, December 2003

Additivity of mutational effects in proteins journal, September 1990

Skeletal muscle injury—molecular changes in the collagen during healing journal, March 1985

Nell-1 enhanced bone mineralization patent-application, May 2006

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies journal, May 2009

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects journal, March 2006

Regulation of bone morphogenetic proteins in early embryonic development journal, October 2004

Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats journal, December 1996

Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15 journal, January 2002

The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals journal, December 1998

Cranial and vertebral defects associated with loss-of-function of Nell patent-application, March 2006

Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts journal, March 2007

The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD) journal, June 2004

Bone marrow cells for cardiac regeneration and repair: current status and issues journal, July 2006

The osteoinductive properties of Nell-1 in a rat spinal fusion model journal, January 2007

Biological and Biomaterial Approaches for Improved Islet Transplantation journal, June 2006

Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene journal, August 2007

Effects of Administration Route on Migration and Distribution of Neural Progenitor Cells Transplanted into Rats with Focal Cerebral Ischemia, an MRI Study journal, November 2009

The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage journal, April 1999

Nell-1 induced bone formation within the distracted intermaxillary suture journal, January 2006

NELL-1 enhanced bone mineralization patent, May 2006

A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation journal, October 2007

Clinical xenotransplantation: the next medical revolution? journal, February 2012

Human NELL-1 Expressed in Unilateral Coronal Synostosis journal, January 1999

Stem Cell Therapy in Perspective journal, February 2003

Cells as vehicles for therapeutic genes to treat liver diseases journal, April 2008

Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development journal, December 2003

Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1 patent-application, April 2009

Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice journal, June 2001

A new function of Nell-1 protein in repressing adipogenic differentiation journal, July 2011

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression journal, January 2004

Nell-1-Induced Bone Regeneration in Calvarial Defects journal, September 2006

Quantitative Comparison of Constitutive Promoters in Human ES cells
journal, August 2010

Gene therapy for muscular dystrophy: current progress and future prospects
journal, June 2009

Coagulation dysregulation as a barrier to xenotransplantation in the primate
journal, June 2009

NELL-1 enhanced bone mineralization
patent-application, October 2006

Expression system of NELL peptide
patent-application, June 2007

Cell-Based Approaches for Cardiac Repair
journal, October 2006

Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
journal, January 2001

Application ofex VivoGene Therapy in the Treatment of Parkinson's Disease
journal, March 1997

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Adenovirus vectors encoding brain natriuretic peptide
patent-application, February 2006

Effect of collagen matrices on dermal wound healing
journal, November 2003

Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development
journal, May 2006

Nell peptide expression systems and bone formation activity of nell peptide
patent-application, December 2006

Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2
journal, November 1999

Method to Treat or Prevent a Skin Condition Using a Nell 1 Peptide
patent-application, September 2011

From cardiac repair to cardiac regeneration – ready to translate?
journal, August 2006

Ex vivo gene transfer and correction for cell-based therapies
journal, March 2011

In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7
journal, January 2005

Current Concepts In Intervertebral Disk Restoration
journal, July 2000

Growth Factor Enhancement of Cardiac Regeneration
journal, January 2006

Wound Healing--Aiming for Perfect Skin Regeneration
journal, April 1997

Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C
journal, November 1999

Composition for cartilage
patent-application, June 2007

BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
journal, December 2003

Additivity of mutational effects in proteins
journal, September 1990

Skeletal muscle injury—molecular changes in the collagen during healing
journal, March 1985

Nell-1 enhanced bone mineralization
patent-application, May 2006

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies
journal, May 2009

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects
journal, March 2006

Regulation of bone morphogenetic proteins in early embryonic development
journal, October 2004

Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats
journal, December 1996

Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15
journal, January 2002

The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals
journal, December 1998

Cranial and vertebral defects associated with loss-of-function of Nell
patent-application, March 2006

Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts
journal, March 2007

The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)
journal, June 2004

Bone marrow cells for cardiac regeneration and repair: current status and issues
journal, July 2006

The osteoinductive properties of Nell-1 in a rat spinal fusion model
journal, January 2007

Biological and Biomaterial Approaches for Improved Islet Transplantation
journal, June 2006

Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
journal, August 2007

Effects of Administration Route on Migration and Distribution of Neural Progenitor Cells Transplanted into Rats with Focal Cerebral Ischemia, an MRI Study
journal, November 2009

The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage
journal, April 1999

Nell-1 induced bone formation within the distracted intermaxillary suture
journal, January 2006

NELL-1 enhanced bone mineralization
patent, May 2006

A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation
journal, October 2007

Clinical xenotransplantation: the next medical revolution?
journal, February 2012

Human NELL-1 Expressed in Unilateral Coronal Synostosis
journal, January 1999

Stem Cell Therapy in Perspective
journal, February 2003

Cells as vehicles for therapeutic genes to treat liver diseases
journal, April 2008

Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
journal, December 2003

Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1
patent-application, April 2009

Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
journal, June 2001

A new function of Nell-1 protein in repressing adipogenic differentiation
journal, July 2011

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
journal, January 2004

Nell-1-Induced Bone Regeneration in Calvarial Defects
journal, September 2006