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Title: Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1

Abstract

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

Inventors:
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1429850
Patent Number(s):
9920104
Application Number:
14/495,942
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Sep 25
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1. United States: N. p., 2018. Web.
Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1. United States.
Culiat, Cymbeline T. Tue . "Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1". United States. https://www.osti.gov/servlets/purl/1429850.
@article{osti_1429850,
title = {Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1},
author = {Culiat, Cymbeline T.},
abstractNote = {The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {3}
}

Patent:

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Works referenced in this record:

Quantitative Comparison of Constitutive Promoters in Human ES cells
journal, August 2010


Gene therapy for muscular dystrophy: current progress and future prospects
journal, June 2009


Coagulation dysregulation as a barrier to xenotransplantation in the primate
journal, June 2009


Cell-Based Approaches for Cardiac Repair
journal, October 2006


Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
journal, January 2001


Application ofex VivoGene Therapy in the Treatment of Parkinson's Disease
journal, March 1997


Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994


Effect of collagen matrices on dermal wound healing
journal, November 2003


Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development
journal, May 2006


Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2
journal, November 1999


From cardiac repair to cardiac regeneration – ready to translate?
journal, August 2006


Ex vivo gene transfer and correction for cell-based therapies
journal, March 2011


Current Concepts In Intervertebral Disk Restoration
journal, July 2000


Growth Factor Enhancement of Cardiac Regeneration
journal, January 2006


Wound Healing--Aiming for Perfect Skin Regeneration
journal, April 1997


Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C
journal, November 1999


BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
journal, December 2003


Additivity of mutational effects in proteins
journal, September 1990


Skeletal muscle injury—molecular changes in the collagen during healing
journal, March 1985


Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies
journal, May 2009


Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects
journal, March 2006


Regulation of bone morphogenetic proteins in early embryonic development
journal, October 2004


Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats
journal, December 1996


The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals
journal, December 1998


Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts
journal, March 2007


The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)
journal, June 2004

  • Tsutsumi, Satoshi; Kamata, Nobuyuki; Vokes, Tamara J.
  • The American Journal of Human Genetics, Vol. 74, Issue 6, p. 1255-1261
  • https://doi.org/10.1086/421527

Bone marrow cells for cardiac regeneration and repair: current status and issues
journal, July 2006


The osteoinductive properties of Nell-1 in a rat spinal fusion model
journal, January 2007


Biological and Biomaterial Approaches for Improved Islet Transplantation
journal, June 2006


Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
journal, August 2007


Effects of Administration Route on Migration and Distribution of Neural Progenitor Cells Transplanted into Rats with Focal Cerebral Ischemia, an MRI Study
journal, November 2009


Craniosynostosis in transgenic mice overexpressing Nell-1
journal, September 2002


Nell-1 induced bone formation within the distracted intermaxillary suture
journal, January 2006


A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation
journal, October 2007


Clinical xenotransplantation: the next medical revolution?
journal, February 2012


Human NELL-1 Expressed in Unilateral Coronal Synostosis
journal, January 1999


Stem Cell Therapy in Perspective
journal, February 2003


Cells as vehicles for therapeutic genes to treat liver diseases
journal, April 2008


Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
journal, December 2003


Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
journal, June 2001


A new function of Nell-1 protein in repressing adipogenic differentiation
journal, July 2011


Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
journal, January 2004


Nell-1-Induced Bone Regeneration in Calvarial Defects
journal, September 2006