Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1

Culiat, Cymbeline T.

Title: Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1

Patent · Tue Mar 20 00:00:00 EDT 2018

OSTI ID:1429850

Culiat, Cymbeline T.

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-00OR22725

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Number(s):: 9,920,104

Application Number:: 14/495,942

OSTI ID:: 1429850

Resource Relation:: Patent File Date: 2014 Sep 25

Country of Publication:: United States

Language:: English

References (55)

Quantitative Comparison of Constitutive Promoters in Human ES cells Norrman, Karin; Fischer, Yvonne; Bonnamy, Blandine PLoS ONE, Vol. 5, Issue 8, Article No. e12413 https://doi.org/10.1371/journal.pone.0012413	journal	August 2010
Gene therapy for muscular dystrophy: current progress and future prospects Trollet, Capucine; Athanasopoulos, Takis; Popplewell, Linda Expert Opinion on Biological Therapy, Vol. 9, Issue 7, p. 849-866 https://doi.org/10.1517/14712590903029164	journal	June 2009
Coagulation dysregulation as a barrier to xenotransplantation in the primate Lin, Chih Che; Cooper, David K. C.; Dorling, Anthony Transplant Immunology, Vol. 21, Issue 2, p. 75-80 https://doi.org/10.1016/j.trim.2008.10.008	journal	June 2009
NELL-1 enhanced bone mineralization Ting, Kang https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060228392 US Patent Application 11/392294; 20060228392	patent-application	October 2006
Expression system of NELL peptide Ting, Kang; Kuroda, Shunichi; Wu, Ben https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070128697 US Patent Application 11/601529; 20070128697	patent-application	June 2007
Cell-Based Approaches for Cardiac Repair Rubart, M.; Field, L. J. Annals of the New York Academy of Sciences, Vol. 1080, Issue 1, p. 34-48 https://doi.org/10.1196/annals.1380.004	journal	October 2006
Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors Maeda, Kenji; Matsuhashi, Sachiko; Tabuchi, Kazuo Neurologia medico-chirurgica, Vol. 41, Issue 12, p. 582-589 https://doi.org/10.2176/nmc.41.582	journal	January 2001
Application ofex VivoGene Therapy in the Treatment of Parkinson's Disease Raymon, H. K.; Thode, S.; Gage, F. H. Experimental Neurology, Vol. 144, Issue 1, p. 82-91 https://doi.org/10.1006/exnr.1996.6392	journal	March 1997
Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox Ngo, J. Thomas; Marks, Joe; Karplus, Martin The Protein Folding Problem and Tertiary Structure Prediction, p. 433-506 https://doi.org/10.1007/978-1-4684-6831-1_14	book	January 1994
Adenovirus vectors encoding brain natriuretic peptide Simari, Robert D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060025367 US Patent Application 11/185327; 20060025367	patent-application	February 2006
Effect of collagen matrices on dermal wound healing Ruszczak, Z. Advanced Drug Delivery Reviews, Vol. 55, Issue 12, p. 1595-1611 https://doi.org/10.1016/j.addr.2003.08.003	journal	November 2003
Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development Zhang, Xinli; Cowan, Catherine M.; Jiang, Xinquan Laboratory Investigation, Vol. 86, Issue 7, p. 633-644 https://doi.org/10.1038/labinvest.3700430	journal	May 2006
Nell peptide expression systems and bone formation activity of nell peptide Ting, Kang; Kuroda, Shunichi; Wu, Ben https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060292670 US Patent Application 10/544553; 20060292670	patent-application	December 2006
Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2 Kuroda, Shun'ichi; Oyasu, Miho; Kawakami, Masakatsu Biochemical and Biophysical Research Communications, Vol. 265, Issue 1, p. 79-86 https://doi.org/10.1006/bbrc.1999.1638	journal	November 1999
Method to Treat or Prevent a Skin Condition Using a Nell 1 Peptide Mitchell, Dora P.; Culiat, Cymbeline T.; Lubit, Beverly W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110236325 US Patent Application 13/011339; 20110236325	patent-application	September 2011
From cardiac repair to cardiac regeneration – ready to translate? Ott, Harald C.; Taylor, Doris A. Expert Opinion on Biological Therapy, Vol. 6, Issue 9, p. 867-878 https://doi.org/10.1517/14712598.6.9.867	journal	August 2006
Ex vivo gene transfer and correction for cell-based therapies Naldini, Luigi Nature Reviews Genetics, Vol. 12, Issue 5, p. 301-315 https://doi.org/10.1038/nrg2985	journal	March 2011
In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7 Yang, M.; Ma, Q. J.; Dang, G. T. Cytotherapy, Vol. 7, Issue 3, p. 273-281 https://doi.org/10.1080/14653240510027244	journal	January 2005
Current Concepts In Intervertebral Disk Restoration Diwan, Ashish D.; Parvataneni, Hari K.; Khan, Safdar N. Orthopedic Clinics of North America, Vol. 31, Issue 3, p. 453-464 https://doi.org/10.1016/S0030-5898(05)70163-2	journal	July 2000
Growth Factor Enhancement of Cardiac Regeneration Rosenthal, Nadia; Santini, Maria Paola; Musarò, Antonio Cell Transplantation, Vol. 15, Issue S1, p. 41-45 https://doi.org/10.3727/000000006783982287	journal	January 2006
Wound Healing--Aiming for Perfect Skin Regeneration Martin, P. Science, Vol. 276, Issue 5309, p. 75-81 https://doi.org/10.1126/science.276.5309.75	journal	April 1997
Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C Kuroda, Shun'ichi; Tanizawa, Katsuyuki Biochemical and Biophysical Research Communications, Vol. 265, Issue 3, p. 752-757 https://doi.org/10.1006/bbrc.1999.1753	journal	November 1999
Composition for cartilage Ting, Kang; Wu, Ben; Soo, Chia https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070134291 US Patent Application 11/594510; 20070134291	patent-application	June 2007
BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture Schmitt, Bernhard; Ringe, Jochen; Häupl, Thomas Differentiation, Vol. 71, Issue 9-10, p. 567-577 https://doi.org/10.1111/j.1432-0436.2003.07109003.x	journal	December 2003
Additivity of mutational effects in proteins Wells, James A. Biochemistry, Vol. 29, Issue 37, p. 8509-8517 https://doi.org/10.1021/bi00489a001	journal	September 1990
Skeletal muscle injury—molecular changes in the collagen during healing Lehto, M.; Sims, T. J.; Bailey, A. J. Research In Experimental Medicine, Vol. 185, Issue 2, p. 95-106 https://doi.org/10.1007/BF01854894	journal	March 1985
Nell-1 enhanced bone mineralization Ting, Kang https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060111313 US Patent Application 10/527786; 20060111313	patent-application	May 2006
Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies Hentze, Hannes; Soong, Poh Loong; Wang, Siew Tein Stem Cell Research, Vol. 2, Issue 3, p. 198-210 https://doi.org/10.1016/j.scr.2009.02.002	journal	May 2009
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects Desai, Jayashree; Shannon, Mark E.; Johnson, Mahlon D. Human Molecular Genetics, Vol. 15, Issue 8, p. 1329-1341 https://doi.org/10.1093/hmg/ddl053	journal	March 2006
Regulation of bone morphogenetic proteins in early embryonic development Yamamoto, Yukiyo; Oelgeschläger, Michael Naturwissenschaften, Vol. 91, Issue 11, p. 519-534 https://doi.org/10.1007/s00114-004-0575-z	journal	October 2004
Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats Watanabe, Takeshi K.; Katagiri, Toyomasa; Suzuki, Mikio Genomics, Vol. 38, Issue 3, p. 273-276 https://doi.org/10.1006/geno.1996.0628	journal	December 1996
Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15 Rinchik, E. M.; Carpenter, D. A.; Johnson, D. K. Proceedings of the National Academy of Sciences, Vol. 99, Issue 2, p. 844-849 https://doi.org/10.1073/pnas.022628199	journal	January 2002
The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals Pettit, Dean K.; Gombotz, Wayne R. Trends in Biotechnology, Vol. 16, Issue 8, p. 343-349 https://doi.org/10.1016/S0167-7799(98)01186-X	journal	December 1998
Cranial and vertebral defects associated with loss-of-function of Nell Culiat, Cymbeline T.; Rinchik, Eugene M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060053503 US Patent Application 11/192813; 20060053503	patent-application	March 2006
Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts Cowan, Catherine M.; Jiang, Xinquan; Hsu, Tiffany Journal of Bone and Mineral Research, Vol. 22, Issue 6, p. 918-930 https://doi.org/10.1359/jbmr.070312	journal	March 2007
The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD) Tsutsumi, Satoshi; Kamata, Nobuyuki; Vokes, Tamara J. The American Journal of Human Genetics, Vol. 74, Issue 6, p. 1255-1261 https://doi.org/10.1086/421527	journal	June 2004
Bone marrow cells for cardiac regeneration and repair: current status and issues Haider, Husnain Kh Expert Review of Cardiovascular Therapy, Vol. 4, Issue 4, p. 557-568 https://doi.org/10.1586/14779072.4.4.557	journal	July 2006
The osteoinductive properties of Nell-1 in a rat spinal fusion model Lu, Steven S.; Zhang, Xinli; Soo, Chia The Spine Journal, Vol. 7, Issue 1, p. 50-60 https://doi.org/10.1016/j.spinee.2006.04.020	journal	January 2007
Biological and Biomaterial Approaches for Improved Islet Transplantation Narang, Ajit S.; Mahato, Ram I. Pharmacological Reviews, Vol. 58, Issue 2, p. 194-243 https://doi.org/10.1124/pr.58.2.6	journal	June 2006
Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene Franke, Andre; Hampe, Jochen; Rosenstiel, Philip PLoS ONE, Vol. 2, Issue 8, Article No. e691 https://doi.org/10.1371/journal.pone.0000691	journal	August 2007
Effects of Administration Route on Migration and Distribution of Neural Progenitor Cells Transplanted into Rats with Focal Cerebral Ischemia, an MRI Study Li, Lian; Jiang, Quan; Ding, Guangliang Journal of Cerebral Blood Flow & Metabolism, Vol. 30, Issue 3, p. 653-662 https://doi.org/10.1038/jcbfm.2009.238	journal	November 2009
The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage Luce, Milson J.; Burrows, Peter D. Gene, Vol. 231, Issue 1-2, p. 121-126 https://doi.org/10.1016/S0378-1119(99)00093-1	journal	April 1999
Nell-1 induced bone formation within the distracted intermaxillary suture Cowan, Catherine M.; Cheng, Samson; Ting, Kang Bone, Vol. 38, Issue 1, p. 48-58 https://doi.org/10.1016/j.bone.2005.06.023	journal	January 2006
NELL-1 enhanced bone mineralization Ting, Kang https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7052856 US Patent Document 7,052,856	patent	May 2006
A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation Aghaloo, Tara; Jiang, Xinquan; Soo, Chia Molecular Therapy, Vol. 15, Issue 10, p. 1872-1880 https://doi.org/10.1038/sj.mt.6300270	journal	October 2007
Clinical xenotransplantation: the next medical revolution? Ekser, Burcin; Ezzelarab, Mohamed; Hara, Hidetaka The Lancet, Vol. 379, Issue 9816, p. 672-683 https://doi.org/10.1016/S0140-6736(11)61091-X	journal	February 2012
Human NELL-1 Expressed in Unilateral Coronal Synostosis Ting, Kang; Vastardis, Heleni; Mulliken, John B. Journal of Bone and Mineral Research, Vol. 14, Issue 1, p. 80-89 https://doi.org/10.1359/jbmr.1999.14.1.80	journal	January 1999
Stem Cell Therapy in Perspective Strauer, B. E. Circulation, Vol. 107, Issue 7, p. 929-934 https://doi.org/10.1161/01.CIR.0000057525.13182.24	journal	February 2003
Cells as vehicles for therapeutic genes to treat liver diseases Prieto, J.; Fernandez-Ruiz, V.; Kawa, M. P. Gene Therapy, Vol. 15, Issue 10, p. 765-771 https://doi.org/10.1038/gt.2008.44	journal	April 2008
Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development Zhang, Xinli; Carpenter, Dale; Bokui, Nobuyuki Journal of Bone and Mineral Research, Vol. 18, Issue 12, p. 2126-2134 https://doi.org/10.1359/jbmr.2003.18.12.2126	journal	December 2003
Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1 Culiat, Cymbeline T. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090087415 US Patent Application 12/284667; 20090087415	patent-application	April 2009
Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice Orlic, Donald; Kajstura, Jan; Chimenti, Stefano Annals of the New York Academy of Sciences, Vol. 938, Issue 1, p. 221-230 https://doi.org/10.1111/j.1749-6632.2001.tb03592.x	journal	June 2001
A new function of Nell-1 protein in repressing adipogenic differentiation James, Aaron W.; Pan, Angel; Chiang, Michael Biochemical and Biophysical Research Communications, Vol. 411, Issue 1, p. 126-131 https://doi.org/10.1016/j.bbrc.2011.06.111	journal	July 2011
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression Lecker, Stewart H.; Jagoe, R. Thomas; Gilbert, Alexander The FASEB Journal, Vol. 18, Issue 1, p. 39-51 https://doi.org/10.1096/fj.03-0610com	journal	January 2004
Nell-1-Induced Bone Regeneration in Calvarial Defects Aghaloo, Tara; Cowan, Catherine M.; Chou, Yu-Fen The American Journal of Pathology, Vol. 169, Issue 3, p. 903-915 https://doi.org/10.2353/ajpath.2006.051210	journal	September 2006

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