Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1

Culiat, Cymbeline T

Title: Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1

Patent · Tue Mar 22 00:00:00 EDT 2011

OSTI ID:1016346

Culiat, Cymbeline T ^[1]

Oak Ridge, TN

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

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Research Organization:: UT-Battelle LLC/ORNL, Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-00OR22725

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Number(s):: 7,910,542

Application Number:: US Patent Application 12/238,882

OSTI ID:: 1016346

Country of Publication:: United States

Language:: English

References (25)

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Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors Maeda, Kenji; Matsuhashi, Sachiko; Tabuchi, Kazuo Neurologia medico-chirurgica, Vol. 41, Issue 12, p. 582-589 https://doi.org/10.2176/nmc.41.582	journal	January 2001
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The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage Luce, Milson J.; Burrows, Peter D. Gene, Vol. 231, Issue 1-2, p. 121-126 https://doi.org/10.1016/S0378-1119(99)00093-1	journal	April 1999
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Nell-1-Induced Bone Regeneration in Calvarial Defects Aghaloo, Tara; Cowan, Catherine M.; Chou, Yu-Fen The American Journal of Pathology, Vol. 169, Issue 3, p. 903-915 https://doi.org/10.2353/ajpath.2006.051210	journal	September 2006

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