Hybridization and sequencing of nucleic acids using base pair mismatches
Abstract
Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution, light-directed techniques. Positions of hybridization of a target nucleic acid are determined by, e.g., epifluorescence microscopy. Devices and techniques are proposed to determine the sequence of a target nucleic acid more efficiently and more quickly through such synthesis and detection techniques.
- Inventors:
-
- Palo Alto, CA
- Mt. View, CA
- Issue Date:
- Research Org.:
- Affymax Research Institute
- OSTI Identifier:
- 873966
- Patent Number(s):
- 6284460
- Assignee:
- Affymetrix Inc. (Santa Clara, CA)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
- DOE Contract Number:
- FG03-92ER81275
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- hybridization; sequencing; nucleic; acids; base; pair; mismatches; devices; techniques; determining; sequence; arrays; formed; preferably; resolution; light-directed; positions; target; acid; determined; epifluorescence; microscopy; proposed; determine; efficiently; quickly; synthesis; detection; detection techniques; nucleic acid; nucleic acids; target nucleic; base pair; epifluorescence microscopy; light-directed techniques; target nuclei; /435/999/
Citation Formats
Fodor, Stephen P. A., Lipshutz, Robert J, and Huang, Xiaohua. Hybridization and sequencing of nucleic acids using base pair mismatches. United States: N. p., 2001.
Web.
Fodor, Stephen P. A., Lipshutz, Robert J, & Huang, Xiaohua. Hybridization and sequencing of nucleic acids using base pair mismatches. United States.
Fodor, Stephen P. A., Lipshutz, Robert J, and Huang, Xiaohua. Mon .
"Hybridization and sequencing of nucleic acids using base pair mismatches". United States. https://www.osti.gov/servlets/purl/873966.
@article{osti_873966,
title = {Hybridization and sequencing of nucleic acids using base pair mismatches},
author = {Fodor, Stephen P. A. and Lipshutz, Robert J and Huang, Xiaohua},
abstractNote = {Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution, light-directed techniques. Positions of hybridization of a target nucleic acid are determined by, e.g., epifluorescence microscopy. Devices and techniques are proposed to determine the sequence of a target nucleic acid more efficiently and more quickly through such synthesis and detection techniques.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2001},
month = {Mon Jan 01 00:00:00 EST 2001}
}
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Works referenced in this record:
Sequencing of megabase plus DNA by hybridization: Theory of the method
journal, February 1989
- Dramanac, Radoje; Labat, Ivan; Brukner, Ivan
- Genomics, Vol. 4, Issue 2, p. 114-128
Sequencing of pools of nucleic acids on oligonucleotide arrays
journal, January 1993
- Chetverin, Alexander B.; Kramer, Fred Russell
- Biosystems, Vol. 30, Issue 1-3
Likelihood DNA Sequencing By Hybridization
journal, December 1993
- Lipshutz, Robert J.
- Journal of Biomolecular Structure and Dynamics, Vol. 11, Issue 3
An oligonucleotide hybridization approach to DNA sequencing
journal, October 1989
- Khrapko, K. R.; P. Lysov, Yu; Khorlyn, A. A.
- FEBS Letters, Vol. 256, Issue 1-2, p. 118-122
Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models
journal, August 1992
- Southern, E. M.; Maskos, U.; Elder, J. K.
- Genomics, Vol. 13, Issue 4, p. 1008-1017
DNA sequencing with chain-terminating inhibitors
journal, December 1977
- Sanger, F.; Nicklen, S.; Coulson, A. R.
- Proceedings of the National Academy of Sciences, Vol. 74, Issue 12
Analysis of DNA Oligonucleotide Hybridization Data by Maximum Entropy
book, January 1993
- Elder, J. K.
- Maximum Entropy and Bayesian Methods
A new method for sequencing DNA.
journal, February 1977
- Maxam, A. M.; Gilbert, W.
- Proceedings of the National Academy of Sciences, Vol. 74, Issue 2