Title: Antibody evolution immunogens

Abstract

The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).

Inventors:

Haynes, Barton F.; Liao, Hua-Xin; Lynch, Rebecca M.; Zhou, Tongqing; Gao, Feng; Boyd, Scott; Shaw, George M.; Hahn, Beatrice H.; Kepler, Thomas B.; Korber, Bette T.; Kwong, Peter; Mascola, John R.

Issue Date:

Tue Dec 01 00:00:00 EST 2020

Research Org.:

Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1771680

Patent Number(s):

10849970

Application Number:

15/864,822

Assignee:

Duke University (Durham, NC); Triad National Security, LLC (Los Alamos, NM); The Trustees of the University of Pennsylvania (Philadelphia, PA); TRUSTEES OF BOSTON UNIVERSITY (Boston, MA); The United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, MD); The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K2039/57 - {characterised by the type of response, e.g. Th1, Th2}
A61K39/12 - Viral antigens
A61K39/21 - Retroviridae, e.g. equine infectious anemia virus

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P31/18 - for HIV
A61P37/04 - Immunostimulants

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/005 - from viruses

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N2740/15022 - New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N2740/16022 - New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N2740/16122 - New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N2740/16134 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N7/00 - Viruses

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DOE Contract Number:  

AC52-06NA25396

Resource Type:

Patent

Resource Relation:

Patent File Date: 01/08/2018

Country of Publication:

United States

Language:

English