Mosaic HIV envelope immunogenic polypeptides
Abstract
Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1415621
- Patent Number(s):
- 9855329
- Application Number:
- 15/025,806
- Assignee:
- Los Alamos National Security, LLC (Los Alamos, NM); Dana-Farber Cancer Institute (Brookline, MA); Duke University (Durham, NC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2016 Apr 02
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Korber, Bette T. M., Gnanakaran, S., Perkins, Simon, Sodroski, Joseph, and Haynes, Barton. Mosaic HIV envelope immunogenic polypeptides. United States: N. p., 2018.
Web.
Korber, Bette T. M., Gnanakaran, S., Perkins, Simon, Sodroski, Joseph, & Haynes, Barton. Mosaic HIV envelope immunogenic polypeptides. United States.
Korber, Bette T. M., Gnanakaran, S., Perkins, Simon, Sodroski, Joseph, and Haynes, Barton. Tue .
"Mosaic HIV envelope immunogenic polypeptides". United States. https://www.osti.gov/servlets/purl/1415621.
@article{osti_1415621,
title = {Mosaic HIV envelope immunogenic polypeptides},
author = {Korber, Bette T. M. and Gnanakaran, S. and Perkins, Simon and Sodroski, Joseph and Haynes, Barton},
abstractNote = {Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {1}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Ancestral and COT viral sequences, proteins and immunogenic compositions
patent-application, June 2005
- Mullins, James I.; Rodrigo, Allen G.; Learn, Gerald H.
- US Patent Document 10/780507; 20050137387
HIVcon: An HIV Immunogen And Uses Thereof
patent-application, October 2010
- Hanke, Tomas; McMichael, Andrew James
- US Patent Application 12/725651; 20100266635
HIV-1 Envelope Polypeptides for HIV Vaccine
patent-application, December 2011
- Duch, Mogens Ryttergaard; Pedersen, Finn Skou; Bahrami, Shervin
- US Patent Application 13/060564; 20110305749
Polyvalent Vaccine
patent-application, September 2012
- Korber, Bette T.; Perkins, Simon; Bhattacharya, Tammoy
- US Patent Application 13/399963; 20120231028
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010
- Barouch, Dan H.; O'Brien, Kara L.; Simmons, Nathaniel L.
- Nature Medicine, Vol. 16, Issue 3, p. 319-323
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006
- Fischer, Will; Perkins, Simon; Theiler, James
- Nature Medicine, Vol. 13, Issue 1, p. 100-106
HIV-1: From escapism to conservatism
journal, November 2011
- Hanke, Tomáš; McMichael, Andrew J.
- European Journal of Immunology, Vol. 41, Issue 12, p. 3390-3393
Design and Pre-Clinical Evaluation of a Universal HIV-1 Vaccine
journal, October 2007
- Létourneau, Sven; Im, Eung-Jun; Mashishi, Tumelo
- PLoS ONE, Vol. 2, Issue 10, Article No. e984
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010
- Santra, Sampa; Liao, Hua-Xin; Zhang, Ruijin
- Nature Medicine, Vol. 16, Issue 3, p. 324-328