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Title: Mosaic HIV envelope immunogenic polypeptides

Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
1415621
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM); Dana-Farber Cancer Institute (Brookline, MA); Duke University (Durham, NC) LANL
Patent Number(s):
9,855,329
Application Number:
15/025,806
Contract Number:
AC52-06NA25396
Resource Relation:
Patent File Date: 2016 Apr 02
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
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Works referenced in this record:

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010
  • Barouch, Dan H.; O'Brien, Kara L.; Simmons, Nathaniel L.
  • Nature Medicine, Vol. 16, Issue 3, p. 319-323
  • DOI: 10.1038/nm.2089
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006
  • Fischer, Will; Perkins, Simon; Theiler, James
  • Nature Medicine, Vol. 13, Issue 1, p. 100-106
  • DOI: 10.1038/nm1461
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010
  • Santra, Sampa; Liao, Hua-Xin; Zhang, Ruijin
  • Nature Medicine, Vol. 16, Issue 3, p. 324-328
  • DOI: 10.1038/nm.2108

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