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Title: Immunogenic peptides comprising a T-helper epitope and a B-cell neutralizing antibody epitope

Patent ·
OSTI ID:904221

The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for use in such a method.

Research Organization:
Univ. of California (United States); Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
W-7405-ENG-36
Assignee:
Duke University (Durham, NC); The Regents of the University of Calforinia (Oakland, CA)
Patent Number(s):
7,153,509
Application Number:
10/289,228
OSTI ID:
904221
Country of Publication:
United States
Language:
English

References (4)

Safety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen journal January 1998
HIV Vaccine Development at Duke University Medical Center journal January 2000
HIV Type 1 V3 Region Primer-Induced Antibody Suppression Is Overcome by Administration of C4-V3 Peptides as a Polyvalent Immunogen journal February 1995
Phage display of peptide epitopes from HIV-1 elicits strong cytolytic responses journal August 2000

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