DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens

Abstract

The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1178261
Patent Number(s):
9011873
Application Number:
13/094,734
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Apr 26
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Korber, Bette T, Fischer, William, Liao, Hua-Xin, Haynes, Barton F, Letvin, Norman, and Hahn, Beatrice H. Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens. United States: N. p., 2015. Web.
Korber, Bette T, Fischer, William, Liao, Hua-Xin, Haynes, Barton F, Letvin, Norman, & Hahn, Beatrice H. Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens. United States.
Korber, Bette T, Fischer, William, Liao, Hua-Xin, Haynes, Barton F, Letvin, Norman, and Hahn, Beatrice H. Tue . "Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens". United States. https://www.osti.gov/servlets/purl/1178261.
@article{osti_1178261,
title = {Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens},
author = {Korber, Bette T and Fischer, William and Liao, Hua-Xin and Haynes, Barton F and Letvin, Norman and Hahn, Beatrice H},
abstractNote = {The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {4}
}

Works referenced in this record:

Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
journal, January 2014


Toward an AIDS Vaccine
journal, May 2008


The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years
journal, September 2005


Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
journal, September 2004


Evolutionary and immunological implications of contemporary HIV-1 variation
journal, September 2001


Diversity Considerations in HIV-1 Vaccine Selection
journal, June 2002


HIV vaccine strategies
journal, February 2002


HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus
journal, November 2002


Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006


Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity
journal, January 2006


Prospects for an AIDS vaccine
journal, March 2004


Progress and obstacles in the development of an AIDS vaccine
journal, December 2006


HIV VACCINES
journal, December 2005


DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice
journal, February 1998


Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010


Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination
journal, December 2008


Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010


T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces
journal, May 2009


A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys
journal, July 2008