Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens

Korber, Bette T; Fischer, William; Liao, Hua-Xin; Haynes, Barton F; Letvin, Norman; Hahn, Beatrice H

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Title: Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens

Abstract

The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Inventors:: Korber, Bette T; Fischer, William; Liao, Hua-Xin; Haynes, Barton F; Letvin, Norman; Hahn, Beatrice H

Issue Date:: 2015-04-21

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1178261

Patent Number(s):: 9011873

Application Number:: 13/094,734

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Show more

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2039/53 - {DNA
A61K2039/70 - {Multivalent vaccine}
A61K39/12 - Viral antigens
A61K39/21 - Retroviridae, e.g. equine infectious anemia virus

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/12 - Antivirals
A61P31/18 - for HIV
A61P37/00 - Drugs for immunological or allergic disorders
A61P37/04 - Immunostimulants

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/005 - from viruses

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N2710/24143 - viral genome or elements thereof as genetic vector
C12N2740/16022 - New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N2740/16034 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N2740/16122 - New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N2740/16134 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N2740/16234 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N2740/16334 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N7/00 - Viruses

Show less

DOE Contract Number:: AC52-06NA25396

Resource Type:: Patent

Resource Relation:: Patent File Date: 2011 Apr 26

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Korber, Bette T, Fischer, William, Liao, Hua-Xin, Haynes, Barton F, Letvin, Norman, and Hahn, Beatrice H. Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens.  United States: N. p., 2015. 
        Web.

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                    Korber, Bette T, Fischer, William, Liao, Hua-Xin, Haynes, Barton F, Letvin, Norman, & Hahn, Beatrice H. Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens.  United States.

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                    Korber, Bette T, Fischer, William, Liao, Hua-Xin, Haynes, Barton F, Letvin, Norman, and Hahn, Beatrice H. Tue .  
        "Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens".  United States.  https://www.osti.gov/servlets/purl/1178261.

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@article{osti_1178261,

  title        = {Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens},

  author       = {Korber, Bette T and Fischer, William and Liao, Hua-Xin and Haynes, Barton F and Letvin, Norman and Hahn, Beatrice H},

  abstractNote = {The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {4}

}

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Similar Records

Title: Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens

Abstract

Citation Formats

Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates journal, January 2014

Toward an AIDS Vaccine journal, May 2008

The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years journal, September 2005

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice journal, September 2004

Evolutionary and immunological implications of contemporary HIV-1 variation journal, September 2001

Diversity Considerations in HIV-1 Vaccine Selection journal, June 2002

HIV vaccine strategies journal, February 2002

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus journal, November 2002

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants journal, December 2006

Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity journal, January 2006

Prospects for an AIDS vaccine journal, March 2004

Progress and obstacles in the development of an AIDS vaccine journal, December 2006

HIV VACCINES journal, December 2005

Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope journal, August 2005

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice journal, February 1998

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys journal, February 2010

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination journal, December 2008

Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys journal, February 2010

T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces journal, May 2009

A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys journal, July 2008

Ancestral and COT viral sequences, proteins and immunogenic compositions patent, February 2010

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens patent, May 2011

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins patent, February 2012

Antigen Library Immunization patent-application, December 2002

Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications patent-application, March 2003

Method for the development of an HIV vaccine patent-application, June 2003

Polyvalent immunogen patent-application, August 2003

Immunogenic, cross-clade, HIV peptides patent-application, September 2003

Peptide compositions for the treatment and prevention of HIV infection patent-application, October 2003

Polyvalent immunogen patent-application, January 2004

Ancestral and COT viral sequences, proteins and immunogenic compositions patent-application, June 2005

Immunogenic hiv-1 multi-clade, multivalent constructs and methods of their use patent-application, September 2006

HIV vaccines based on Env of multiple clades of HIV patent-application, December 2006

Consensus/ancestral immunogens patent-application, August 2007

Polyvalent Vaccine patent-application, December 2009

Polyvalent Vaccine patent-application, June 2011

Polyvalent Vaccine patent-application, May 2012

Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
journal, January 2014

Toward an AIDS Vaccine
journal, May 2008

The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years
journal, September 2005

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
journal, September 2004

Evolutionary and immunological implications of contemporary HIV-1 variation
journal, September 2001

Diversity Considerations in HIV-1 Vaccine Selection
journal, June 2002

HIV vaccine strategies
journal, February 2002

HIV-1 superinfection despite broad CD⁸⁺ T-cell responses containing replication of the primary virus
journal, November 2002

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006

Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity
journal, January 2006

Prospects for an AIDS vaccine
journal, March 2004

Progress and obstacles in the development of an AIDS vaccine
journal, December 2006

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Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope
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Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
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Mosaic vaccines elicit CD8⁺ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
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A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys
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Ancestral and COT viral sequences, proteins and immunogenic compositions
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Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications
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Ancestral and COT viral sequences, proteins and immunogenic compositions
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patent-application, December 2009

Polyvalent Vaccine
patent-application, June 2011

Polyvalent Vaccine
patent-application, May 2012