Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens
Abstract
The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1178261
- Patent Number(s):
- 9011873
- Application Number:
- 13/094,734
- Assignee:
- Los Alamos National Security, LLC (Los Alamos, NM)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2011 Apr 26
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Korber, Bette T, Fischer, William, Liao, Hua-Xin, Haynes, Barton F, Letvin, Norman, and Hahn, Beatrice H. Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens. United States: N. p., 2015.
Web.
Korber, Bette T, Fischer, William, Liao, Hua-Xin, Haynes, Barton F, Letvin, Norman, & Hahn, Beatrice H. Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens. United States.
Korber, Bette T, Fischer, William, Liao, Hua-Xin, Haynes, Barton F, Letvin, Norman, and Hahn, Beatrice H. Tue .
"Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens". United States. https://www.osti.gov/servlets/purl/1178261.
@article{osti_1178261,
title = {Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens},
author = {Korber, Bette T and Fischer, William and Liao, Hua-Xin and Haynes, Barton F and Letvin, Norman and Hahn, Beatrice H},
abstractNote = {The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {4}
}
Works referenced in this record:
Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
journal, January 2014
- Haynes, Barton F.; Montefiori, David C.
- Expert Review of Vaccines, Vol. 5, Issue 3, p. 347-363
Toward an AIDS Vaccine
journal, May 2008
- Walker, Bruce D.; Burton, Dennis R.
- Science, Vol. 320, Issue 5877, p. 760-764
The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years
journal, September 2005
- Gallo, Robert C.
- The Lancet, Vol. 366, Issue 9500, p. 1894-1898
Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
journal, September 2004
- Shinoda, Kaori; Xin, Ke-Qin; Jounai, Nao
- Vaccine, Vol. 22, Issue 27-28, p. 3676-3690
Evolutionary and immunological implications of contemporary HIV-1 variation
journal, September 2001
- Korber, B.
- British Medical Bulletin, Vol. 58, Issue 1, p. 19-42
Diversity Considerations in HIV-1 Vaccine Selection
journal, June 2002
- Gaschen, Brian; Taylor, Jesse; Yusim, Karina
- Science, Vol. 296, Issue 5577, p. 2354-2360
HIV vaccine strategies
journal, February 2002
- Nabel, Gary J.
- Vaccine, Vol. 20, Issue 15, p. 1945-1947
HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus
journal, November 2002
- Altfeld, Marcus; Allen, Todd M.; Yu, Xu G.
- Nature, Vol. 420, Issue 6914, p. 434-439
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006
- Fischer, Will; Perkins, Simon; Theiler, James
- Nature Medicine, Vol. 13, Issue 1, p. 100-106
Antigenicity and Immunogenicity of a Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein
journal, December 2004
- Gao, F.; Weaver, E. A.; Lu, Z.
- Journal of Virology, Vol. 79, Issue 2, p. 1154-1163
Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity
journal, January 2006
- Peng, Bo; Voltan, Rebecca; Cristillo, Anthony D.
- AIDS, Vol. 20, Issue 17, p. 2149-2157
Prospects for an AIDS vaccine
journal, March 2004
- Desrosiers, Ronald C.
- Nature Medicine, Vol. 10, Issue 3, p. 221-223
Progress and obstacles in the development of an AIDS vaccine
journal, December 2006
- Letvin, Norman L.
- Nature Reviews Immunology, Vol. 6, Issue 12
HIV VACCINES
journal, December 2005
- McMichael, Andrew J.
- Annual Review of Immunology, Vol. 24, Issue 1, p. 227-255
Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope
journal, August 2005
- Doria-Rose, N. A.; Learn, G. H.; Rodrigo, A. G.
- Journal of Virology, Vol. 79, Issue 17, p. 11214-11224
DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice
journal, February 1998
- Hanke, Tomas; Schneider, Jorg; Gilbert, Sarah C.
- Vaccine, Vol. 16, Issue 4, p. 426-435
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010
- Barouch, Dan H.; O'Brien, Kara L.; Simmons, Nathaniel L.
- Nature Medicine, Vol. 16, Issue 3, p. 319-323
Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination
journal, December 2008
- Kong, W.-P.; Wu, L.; Wallstrom, T. C.
- Journal of Virology, Vol. 83, Issue 5, p. 2201-2215
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010
- Santra, Sampa; Liao, Hua-Xin; Zhang, Ruijin
- Nature Medicine, Vol. 16, Issue 3, p. 324-328
T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces
journal, May 2009
- Korber, B. T.; Letvin, N. L.; Haynes, B. F.
- Journal of Virology, Vol. 83, Issue 17, p. 8300-8314
A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys
journal, July 2008
- Santra, S.; Korber, B. T.; Muldoon, M.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 30, p. 10489-10494