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Title: Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins

Abstract

The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Inventors:
 [1];  [1];  [1];  [1];  [1];  [2];  [3];  [4];  [1];  [1]
  1. Los Alamos, NM
  2. Boston, MA
  3. Durham, NC
  4. Birmingham, AL
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1036518
Patent Number(s):
8119140
Application Number:
11/990,222
Assignee:
Los Alamos Security, LLC (Los Alamos, NM); Beth Israel Deaconess Medical Center (Boston, MA); Duke University (Durham, NC); The University of Alabama at Birmingham Research Foundation (Birmingham, AL)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Korber, Bette T, Perkins, Simon, Bhattacharya, Tanmoy, Fischer, William M, Theiler, James, Letvin, Norman, Haynes, Barton F, Hahn, Beatrice H, Yusim, Karina, and Kuiken, Carla. Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins. United States: N. p., 2012. Web.
Korber, Bette T, Perkins, Simon, Bhattacharya, Tanmoy, Fischer, William M, Theiler, James, Letvin, Norman, Haynes, Barton F, Hahn, Beatrice H, Yusim, Karina, & Kuiken, Carla. Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins. United States.
Korber, Bette T, Perkins, Simon, Bhattacharya, Tanmoy, Fischer, William M, Theiler, James, Letvin, Norman, Haynes, Barton F, Hahn, Beatrice H, Yusim, Karina, and Kuiken, Carla. Tue . "Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins". United States. https://www.osti.gov/servlets/purl/1036518.
@article{osti_1036518,
title = {Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins},
author = {Korber, Bette T and Perkins, Simon and Bhattacharya, Tanmoy and Fischer, William M and Theiler, James and Letvin, Norman and Haynes, Barton F and Hahn, Beatrice H and Yusim, Karina and Kuiken, Carla},
abstractNote = {The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {2}
}

Works referenced in this record:

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
journal, September 2004