Compositions containing amino acids, phosphate and manganese and their uses
Abstract
The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.
- Inventors:
- Issue Date:
- Research Org.:
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1390218
- Patent Number(s):
- 9758760
- Application Number:
- 14/962,596
- Assignee:
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- FG02-04ER63918
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2015 Dec 08
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Daly, Michael J., and Gaidamakova, Elena K. Compositions containing amino acids, phosphate and manganese and their uses. United States: N. p., 2017.
Web.
Daly, Michael J., & Gaidamakova, Elena K. Compositions containing amino acids, phosphate and manganese and their uses. United States.
Daly, Michael J., and Gaidamakova, Elena K. Tue .
"Compositions containing amino acids, phosphate and manganese and their uses". United States. https://www.osti.gov/servlets/purl/1390218.
@article{osti_1390218,
title = {Compositions containing amino acids, phosphate and manganese and their uses},
author = {Daly, Michael J. and Gaidamakova, Elena K.},
abstractNote = {The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {9}
}
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