Compositions containing amino acids, phosphate and manganese and their uses

Title: Compositions containing amino acids, phosphate and manganese and their uses

Abstract

The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.

Inventors:: Daly, Michael J.; Gaidamakova, Elena K.

Issue Date:: 2017-09-12

Research Org.:: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1390218

Patent Number(s):: 9758760

Application Number:: 14/962,596

Assignee:: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K39/12 - Viral antigens
A61K39/0258 - {Escherichia}
A61K2039/522 - {avirulent or attenuated}
A61K39/02 - Bacterial antigens

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N2795/10334 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N2710/00061 - Methods of inactivation or attenuation

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2039/521 - {inactivated

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02A - TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
Y02A50/30 - Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K39/085 - Staphylococcus
A61K31/7072 - having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
A61K2039/5252 - {inactivated

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P37/04 - Immunostimulants

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N1/20 - Bacteria {

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/7076 - containing purines, e.g. adenosine, adenylic acid

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N7/00 - Viruses

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DOE Contract Number:: FG02-04ER63918

Resource Type:: Patent

Resource Relation:: Patent File Date: 2015 Dec 08

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Daly, Michael J., and Gaidamakova, Elena K. Compositions containing amino acids, phosphate and manganese and their uses.  United States: N. p., 2017. 
        Web.

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                    Daly, Michael J., & Gaidamakova, Elena K. Compositions containing amino acids, phosphate and manganese and their uses.  United States.

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                    Daly, Michael J., and Gaidamakova, Elena K. Tue .  
        "Compositions containing amino acids, phosphate and manganese and their uses".  United States.  https://www.osti.gov/servlets/purl/1390218.

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@article{osti_1390218,

  title        = {Compositions containing amino acids, phosphate and manganese and their uses},

  author       = {Daly, Michael J. and Gaidamakova, Elena K.},

  abstractNote = {The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2017},

  month        = {9}

}

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