Compositions containing amino acids, phosphate and manganese and their uses

Title: Compositions containing amino acids, phosphate and manganese and their uses

Abstract

The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.

Inventors:: Daly, Michael J.; Gaidamakova, Elena K.

Issue Date:: 2017-09-12

Research Org.:: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1390218

Patent Number(s):: 9,758,760

Application Number:: 14/962,596

Assignee:: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

DOE Contract Number:: FG02-04ER63918

Resource Type:: Patent

Resource Relation:: Patent File Date: 2015 Dec 08

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Daly, Michael J., and Gaidamakova, Elena K. Compositions containing amino acids, phosphate and manganese and their uses.  United States: N. p., 2017. 
        Web.

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                    Daly, Michael J., & Gaidamakova, Elena K. Compositions containing amino acids, phosphate and manganese and their uses.  United States.

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                    Daly, Michael J., and Gaidamakova, Elena K. Tue .  
        "Compositions containing amino acids, phosphate and manganese and their uses".  United States.  https://www.osti.gov/servlets/purl/1390218.

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@article{osti_1390218,

  title        = {Compositions containing amino acids, phosphate and manganese and their uses},

  author       = {Daly, Michael J. and Gaidamakova, Elena K.},

  abstractNote = {The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2017},

  month        = {9}

}

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