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Title: Compositions containing amino acids, phosphate and manganese and their uses

The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.
Issue Date:
OSTI Identifier:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. CHO
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2015 Dec 08
Research Org:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

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