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Title: Compositions containing amino acids, phosphate and manganese and their uses

The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.
Inventors:
;
Issue Date:
OSTI Identifier:
1390218
Assignee:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. CHO
Patent Number(s):
9,758,760
Application Number:
14/962,596
Contract Number:
FG02-04ER63918
Resource Relation:
Patent File Date: 2015 Dec 08
Research Org:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Other works cited in this record:

Stabilized liquid enzyme composition for glucose determination
patent, January 1990

Process for the production on an antiviral vaccine, particularly anti-foot and mouth disease vaccine
patent, September 1990

Infant formulas and nutrition products enriched with nucleosides and/or nucleotides and processes for their preparation
patent, November 1991

Method and apparatus of a defined serumfree medical solution
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Nutritive medium for the culture of microorganism
patent, July 1996

Method of inactivation of viral and bacterial blood contaminants
patent, February 2001

Compositions containing amino acids, phosphate and manganese and their uses
patent, January 2016

Proteins having DNA repair promoting activity
patent-application, July 2003

Identification of essential genes in microorganisms
patent-application, February 2004

Capillary membrane stabilization and reduction of tissue injury through use of biodegradable macromolecules with antioxidants and/or other chemicals
patent-application, November 2006

Sunscreen Safety and Efficacy Enhancement with Manganese Complexes via Urocanate Pathway
patent-application, August 2007

Vaccines Comprising Multimeric HSP60 Peptide Carriers
patent-application, October 2009

Protective Vaccine Against Staphylococcus Aureus Biofilms Comprising Cell Wall-Associated Immunogens
patent-application, July 2011

Compositions Containing Purine Nucleosides and Manganese and Their Uses
patent-application, July 2011

Vaccination with Irradiated Listeria Induces Protective T Cell Immunity
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Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance
journal, November 2004
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journal, September 2010
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Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn2+-Peptide Complex from Deinococcus
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A Manganese Porphyrin Complex is a Novel Radiation Protector
journal, July 2004

Potential Utility of Radioprotective Agents in the Practice of Nuclear Medicine
journal, December 2009
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Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance
journal, March 2007
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