Boron containing amino acid compounds and methods for their use

Title: Boron containing amino acid compounds and methods for their use

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Abstract

The present invention provides new boron containing amino acid compounds and methods for making these compounds by contacting melphalan or another nitrogen mustard derivative and sodium borocaptate. The present invention also provides a method of treating a mammal having a tumor by administering to the mammal a therapeutically effective amount of the new boron containing amino acid compounds.

Inventors:

Glass, John D ^[1]; Coderre, Jeffrey A ^[2]

Shoreham, NY
Wading River, NY

Issue Date:: 2000-01-01

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

OSTI Identifier:: 872828

Patent Number(s):: 6017902

Assignee:: Brookhaven Science Associates (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K41/0095 - {Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F5/022 - {without C-boron linkages}

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DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: boron; containing; amino; acid; compounds; methods; provides; contacting; melphalan; nitrogen; mustard; derivative; sodium; borocaptate; method; treating; mammal; tumor; administering; therapeutically; effective; amount; boron containing; effective amount; amino acid; acid compounds; acid compound; containing amino; therapeutically effective; /514/999/

Citation Formats


                    Glass, John D, and Coderre, Jeffrey A. Boron containing amino acid compounds and methods for their use.  United States: N. p., 2000. 
        Web.

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                    Glass, John D, & Coderre, Jeffrey A. Boron containing amino acid compounds and methods for their use.  United States.

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                    Glass, John D, and Coderre, Jeffrey A. Sat .  
        "Boron containing amino acid compounds and methods for their use".  United States.  https://www.osti.gov/servlets/purl/872828.

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@article{osti_872828,

  title        = {Boron containing amino acid compounds and methods for their use},

  author       = {Glass, John D and Coderre, Jeffrey A},

  abstractNote = {The present invention provides new boron containing amino acid compounds and methods for making these compounds by contacting melphalan or another nitrogen mustard derivative and sodium borocaptate. The present invention also provides a method of treating a mammal having a tumor by administering to the mammal a therapeutically effective amount of the new boron containing amino acid compounds.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2000},

  month        = {1}

}

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