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Title: Boron containing amino acid compounds and methods for their use

Abstract

The present invention provides new boron containing amino acid compounds and methods for making these compounds by contacting melphalan or another nitrogen mustard derivative and sodium borocaptate. The present invention also provides a method of treating a mammal having a tumor by administering to the mammal a therapeutically effective amount of the new boron containing amino acid compounds.

Inventors:
 [1];  [2]
  1. Shoreham, NY
  2. Wading River, NY
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
OSTI Identifier:
872828
Patent Number(s):
6017902
Assignee:
Brookhaven Science Associates (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
boron; containing; amino; acid; compounds; methods; provides; contacting; melphalan; nitrogen; mustard; derivative; sodium; borocaptate; method; treating; mammal; tumor; administering; therapeutically; effective; amount; boron containing; effective amount; amino acid; acid compounds; acid compound; containing amino; therapeutically effective; /514/999/

Citation Formats

Glass, John D, and Coderre, Jeffrey A. Boron containing amino acid compounds and methods for their use. United States: N. p., 2000. Web.
Glass, John D, & Coderre, Jeffrey A. Boron containing amino acid compounds and methods for their use. United States.
Glass, John D, and Coderre, Jeffrey A. Sat . "Boron containing amino acid compounds and methods for their use". United States. https://www.osti.gov/servlets/purl/872828.
@article{osti_872828,
title = {Boron containing amino acid compounds and methods for their use},
author = {Glass, John D and Coderre, Jeffrey A},
abstractNote = {The present invention provides new boron containing amino acid compounds and methods for making these compounds by contacting melphalan or another nitrogen mustard derivative and sodium borocaptate. The present invention also provides a method of treating a mammal having a tumor by administering to the mammal a therapeutically effective amount of the new boron containing amino acid compounds.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

Patent:

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