Compositions containing nucleosides and manganese and their uses
Abstract
This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.
- Inventors:
- Issue Date:
- Research Org.:
- Henry Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States); U.S. Dept. of Health and Human Services, Washington, D.C. (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1568561
- Patent Number(s):
- 10342871
- Application Number:
- 14/920,765
- Assignee:
- The Henry Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, MD); The United States of America as represented by the Department of Health and Human Services (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- FG02-04ER63918
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 10/22/2015
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses. United States: N. p., 2019.
Web.
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., & Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses. United States.
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Tue .
"Compositions containing nucleosides and manganese and their uses". United States. https://www.osti.gov/servlets/purl/1568561.
@article{osti_1568561,
title = {Compositions containing nucleosides and manganese and their uses},
author = {Daly, Michael J. and Gaidamakova, Elena K. and Matrosova, Vera Y. and Levine, Rodney L. and Wehr, Nancy B.},
abstractNote = {This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 09 00:00:00 EDT 2019},
month = {Tue Jul 09 00:00:00 EDT 2019}
}
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Works referenced in this record:
Nutritive medium for the culture of microorganism
patent, July 1996
- Jay, Corinne
- US Patent Document 5,536,645
Protective Vaccine Against Staphylococcus Aureus Biofilms Comprising Cell Wall-Associated Immunogens
patent-application, July 2011
- Shirtliff, Mark E.; O'May, Graeme; Leid, Jeff
- US Patent Application 13/121511; 20110177111
Method and apparatus of a defined serumfree medical solution
patent, April 1995
- Lindstrom, Richard L.; Skelnik, Debra
- US Patent Document 5,407,669
Identification of essential genes in microorganisms
patent-application, February 2004
- Wang, Liangsu; Zamudio, Carlos; Malone, Cheryl
- US Patent Application 10/282122; 20040029129
Sunscreen Safety and Efficacy Enhancement with Manganese Complexes via Urocanate Pathway
patent-application, August 2007
- Gupta, Shyam K.
- US Patent Application 11/676284; 20070189992
Capillary membrane stabilization and reduction of tissue injury through use of biodegradable macromolecules with antioxidants and/or other chemicals
patent-application, November 2006
- Zikria, Bashir A.; Zikria, Jemal Dean
- US Patent Application 11/213303; 20060264357
Proteins having DNA repair promoting activity
patent-application, July 2003
- Narumi, Issay; Satoh, Katsuya; Cui, Suzhen
- US Patent Application 10/216862; 20030143707
Process for the production on an antiviral vaccine, particularly anti-foot and mouth disease vaccine
patent, September 1990
- Lombardo, Jorge Héctor; Smolko, Eduardo Esteban; Ugalde, Rodolfo A.
- US Patent Document 4,959,211
Compositions containing nucleosides and manganese and their uses
patent, November 2015
- Daly, Michael J.; Gaidamakova, Elena K.; Matrosova, Vera Y.
- US Patent Document 9,186,406
Vaccines Comprising Multimeric HSP60 Peptide Carriers
patent-application, October 2009
- Cohen, Irun R.; Amir-Kroll, Hila; Cohen, Noam
- US Patent Application 12/296428; 20090269370
Stabilized liquid enzyme composition for glucose determination
patent, January 1990
- Gawronski, Thomas H.
- US Patent Document 4,897,346