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Title: Compositions containing nucleosides and manganese and their uses

Abstract

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Henry Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States); U.S. Dept. of Health and Human Services, Washington, D.C. (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1568561
Patent Number(s):
10342871
Application Number:
14/920,765
Assignee:
The Henry Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, MD); The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FG02-04ER63918
Resource Type:
Patent
Resource Relation:
Patent File Date: 10/22/2015
Country of Publication:
United States
Language:
English

Citation Formats

Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses. United States: N. p., 2019. Web.
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., & Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses. United States.
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Tue . "Compositions containing nucleosides and manganese and their uses". United States. https://www.osti.gov/servlets/purl/1568561.
@article{osti_1568561,
title = {Compositions containing nucleosides and manganese and their uses},
author = {Daly, Michael J. and Gaidamakova, Elena K. and Matrosova, Vera Y. and Levine, Rodney L. and Wehr, Nancy B.},
abstractNote = {This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {7}
}

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Works referenced in this record:

Method and apparatus of a defined serumfree medical solution
patent, April 1995


Process for the production on an antiviral vaccine, particularly anti-foot and mouth disease vaccine
patent, September 1990


Compositions containing nucleosides and manganese and their uses
patent, November 2015