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Title: Boron-containing amino carboxylic acid compounds and uses thereof

Patent ·
OSTI ID:872909
 [1];  [1]
  1. Knoxville, TN
+ Show Author Affiliations

Novel compounds which are useful for boron neutron capture therapy (BNCT) are disclosed. The compounds comprise a stable boron-containing group and an aminocycloalkane carboxylic acid group or a boronated acyclic hydrocarbon-linked amino carboxylic acid. Methods for synthesis of the compounds and for use of the compounds in BNCT are disclosed.

Research Organization:
Univ. of Tennessee, Knoxville, TN (United States)
DOE Contract Number:
FG05-93ER61610
Assignee:
University of Tennessee Research Corporation (Knoxville, TN)
Patent Number(s):
US 6037490
Application Number:
08/923,054
OSTI ID:
872909
Country of Publication:
United States
Language:
English

References (3)

Hydroboration of vinylglycine and allylglycine as a route to boron-derivatives of α-amino acids journal July 1996
Novel polypyrazolylborate ligands: coordination control through 3-substituents of the pyrazole ring journal May 1987
Inhibition of Mn 2+ 2 -Arginase by Borate Leads to the Design of a Transition State Analogue Inhibitor, 2( S )-Amino-6-boronohexanoic Acid journal August 1997

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Related Subjects

boron-containing
amino
carboxylic
acid
compounds
novel
useful
boron
neutron
capture
therapy
bnct
disclosed
comprise
stable
aminocycloalkane
boronated
acyclic
hydrocarbon-linked
methods
synthesis
neutron capture
boron neutron
carboxylic acid
capture therapy
novel compounds
acid compounds
acid compound
containing amino
compounds comprise
novel compound
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