Compositions containing nucleosides and manganese and their uses

Daly, Michael J.; Gaidamakova, Elena K.; Matrosova, Vera Y.; Levine, Rodney L.; Wehr, Nancy B.

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A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
A41 - wearing apparel
A42 - headwear
A43 - footwear
A44 - haberdashery
A45 - hand or travelling articles
A46 - brushware
A47 - furniture
A61 - medical or veterinary science
A62 - life-saving
A63 - sports
A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
B02 - crushing, pulverising, or disintegrating
B03 - separation of solid materials using liquids or using pneumatic tables or jigs
B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
B05 - spraying or atomising in general
B06 - generating or transmitting mechanical vibrations in general
B07 - separating solids from solids
B08 - cleaning
B09 - disposal of solid waste
B21 - mechanical metal-working without essentially removing material
B22 - casting
B23 - machine tools
B24 - grinding
B25 - hand tools
B26 - hand cutting tools
B27 - working or preserving wood or similar material
B28 - working cement, clay, or stone
B29 - working of plastics
B30 - presses
B31 - making articles of paper, cardboard or material worked in a manner analogous to paper
B32 - layered products
B33 - additive manufacturing technology
B41 - printing
B42 - bookbinding
B43 - writing or drawing implements
B44 - decorative arts
B60 - vehicles in general
B61 - railways
B62 - land vehicles for travelling otherwise than on rails
B63 - ships or other waterborne vessels
B64 - aircraft
B65 - conveying
B66 - hoisting
B67 - opening, closing {or cleaning} bottles, jars or similar containers
B68 - saddlery
B81 - microstructural technology
B82 - nanotechnology
B99 - subject matter not otherwise provided for in this section
C - chemistry
C01 - inorganic chemistry
C02 - treatment of water, waste water, sewage, or sludge
C03 - glass
C04 - cements
C05 - fertilisers
C06 - explosives
C07 - organic chemistry
C08 - organic macromolecular compounds
C09 - dyes
C10 - petroleum, gas or coke industries
C11 - animal or vegetable oils, fats, fatty substances or waxes
C12 - biochemistry
C13 - sugar industry
C14 - skins
C21 - metallurgy of iron
C22 - metallurgy
C23 - coating metallic material
C25 - electrolytic or electrophoretic processes
C30 - crystal growth
C40 - combinatorial technology
C99 - subject matter not otherwise provided for in this section
D - textiles
D01 - natural or man-made threads or fibres
D02 - yarns
D03 - weaving
D04 - braiding
D05 - sewing
D06 - treatment of textiles or the like
D07 - ropes
D10 - indexing scheme associated with sublasses of section d, relating to textiles
D21 - paper-making
D99 - subject matter not otherwise provided for in this section
E - fixed constructions
E01 - construction of roads, railways, or bridges
E02 - hydraulic engineering
E03 - water supply
E04 - building
E05 - locks
E06 - doors, windows, shutters, or roller blinds in general
E21 - earth drilling
E99 - subject matter not otherwise provided for in this section
F - mechanical engineering
F01 - machines or engines in general
F02 - combustion engines
F03 - machines or engines for liquids
F04 - positive - displacement machines for liquids
F05 - indexing schemes relating to engines or pumps in various subclasses of classes f01-f04
F15 - fluid-pressure actuators
F16 - engineering elements and units
F17 - storing or distributing gases or liquids
F21 - lighting
F22 - steam generation
F23 - combustion apparatus
F24 - heating
F25 - refrigeration or cooling
F26 - drying
F27 - furnaces
F28 - heat exchange in general
F41 - weapons
F42 - ammunition
F99 - subject matter not otherwise provided for in this section
G - physics
G01 - measuring
G02 - optics
G03 - photography
G04 - horology
G05 - controlling
G06 - computing
G07 - checking-devices
G08 - signalling
G09 - education
G10 - musical instruments
G11 - information storage
G12 - instrument details
G16 - information and communication technology [ict] specially adapted for specific application fields
G21 - nuclear physics
G99 - subject matter not otherwise provided for in this section
H - electricity
H01 - basic electric elements
H02 - generation
H03 - basic electronic circuitry
H04 - electric communication technique
H05 - electric techniques not otherwise provided for
H99 - subject matter not otherwise provided for in this section
Y - new / cross sectional technologies
Y02 - technologies or applications for mitigation or adaptation against climate change
Y04 - information or communication technologies having an impact on other technology areas
Y10 - technical subjects covered by former uspc

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Title: Compositions containing nucleosides and manganese and their uses

Abstract

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.

Inventors:: Daly, Michael J.; Gaidamakova, Elena K.; Matrosova, Vera Y.; Levine, Rodney L.; Wehr, Nancy B.

Issue Date:: Tue Nov 17 00:00:00 EST 2015

Research Org.:: The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc., Bethesda, MD (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1226548

Patent Number(s):: 9186406

Application Number:: 12/673,709

Assignee:: The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc. (Bethesda, MD)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2300/00 - Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K31/7072 - having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
A61K31/7076 - containing purines, e.g. adenosine, adenylic acid
A61K33/32 - Manganese
A61K35/74 - Bacteria
A61K45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K8/24 - Phosphorous
A61K8/44 - Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur
A61K8/606 - {Nucleosides
A61K8/99 - from microorganisms other than algae or fungi, e.g. protozoa or bacteria

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P1/00 - Drugs for disorders of the alimentary tract or the digestive system
A61P15/00 - Drugs for genital or sexual disorders
A61P17/00 - Drugs for dermatological disorders
A61P17/14 - for baldness or alopecia
A61P3/00 - Drugs for disorders of the metabolism
A61P39/00 - General protective or antinoxious agents
A61P39/06 - Free radical scavengers or antioxidants
A61P43/00 - Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P7/00 - Drugs for disorders of the blood or the extracellular fluid
A61P7/06 - Antianaemics

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61Q - SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
A61Q17/04 - Topical preparations for affording protection against sunlight or other radiation

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DOE Contract Number:: FG02-04ER63918

Resource Type:: Patent

Resource Relation:: Patent File Date: 2008 Aug 18

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses.  United States: N. p., 2015. 
        Web.

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                    Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., & Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses.  United States.

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                    Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Tue .  
        "Compositions containing nucleosides and manganese and their uses".  United States.  https://www.osti.gov/servlets/purl/1226548.

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@article{osti_1226548,

  title        = {Compositions containing nucleosides and manganese and their uses},

  author       = {Daly, Michael J. and Gaidamakova, Elena K. and Matrosova, Vera Y. and Levine, Rodney L. and Wehr, Nancy B.},

  abstractNote = {This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Nov 17 00:00:00 EST 2015},

  month        = {Tue Nov 17 00:00:00 EST 2015}

}

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Works referenced in this record:

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Gawronski, Thomas H.
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Process for the production on an antiviral vaccine, particularly anti-foot and mouth disease vaccine
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Nutritive medium for the culture of microorganism
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Proteins having DNA repair promoting activity
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Identification of essential genes in microorganisms
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Capillary membrane stabilization and reduction of tissue injury through use of biodegradable macromolecules with antioxidants and/or other chemicals
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Vaccines Comprising Multimeric HSP60 Peptide Carriers
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Protective Vaccine Against Staphylococcus Aureus Biofilms Comprising Cell Wall-Associated Immunogens
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Extraction of the Radioresistant Factor of Micrococcus radiodurans
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Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance
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Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn²⁺-Peptide Complex from Deinococcus
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Similar Records

Title: Compositions containing nucleosides and manganese and their uses

Abstract

Citation Formats

Stabilized liquid enzyme composition for glucose determination patent, January 1990

Process for the production on an antiviral vaccine, particularly anti-foot and mouth disease vaccine patent, September 1990

Infant formulas and nutrition products enriched with nucleosides and/or nucleotides and processes for their preparation patent, November 1991

Method and apparatus of a defined serumfree medical solution patent, April 1995

Nutritive medium for the culture of microorganism patent, July 1996

Proteins having DNA repair promoting activity patent-application, July 2003

Identification of essential genes in microorganisms patent-application, February 2004

Capillary membrane stabilization and reduction of tissue injury through use of biodegradable macromolecules with antioxidants and/or other chemicals patent-application, November 2006

Sunscreen Safety and Efficacy Enhancement with Manganese Complexes via Urocanate Pathway patent-application, August 2007

Vaccines Comprising Multimeric HSP60 Peptide Carriers patent-application, October 2009

Protective Vaccine Against Staphylococcus Aureus Biofilms Comprising Cell Wall-Associated Immunogens patent-application, July 2011

Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance journal, March 2007

Extraction of the Radioresistant Factor of Micrococcus radiodurans journal, May 1964

Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance journal, November 2004

Small-Molecule Antioxidant Proteome-Shields in Deinococcus radiodurans journal, September 2010

Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection journal, August 2009

Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn2+-Peptide Complex from Deinococcus journal, July 2012

Radioprotection in E. Coli by an Agent from M. Radiodurans journal, January 1978

Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans journal, July 2010

A Manganese Porphyrin Complex is a Novel Radiation Protector journal, July 2004

Stabilized liquid enzyme composition for glucose determination
patent, January 1990

Process for the production on an antiviral vaccine, particularly anti-foot and mouth disease vaccine
patent, September 1990

Infant formulas and nutrition products enriched with nucleosides and/or nucleotides and processes for their preparation
patent, November 1991

Method and apparatus of a defined serumfree medical solution
patent, April 1995

Nutritive medium for the culture of microorganism
patent, July 1996

Proteins having DNA repair promoting activity
patent-application, July 2003

Identification of essential genes in microorganisms
patent-application, February 2004

Capillary membrane stabilization and reduction of tissue injury through use of biodegradable macromolecules with antioxidants and/or other chemicals
patent-application, November 2006

Sunscreen Safety and Efficacy Enhancement with Manganese Complexes via Urocanate Pathway
patent-application, August 2007

Vaccines Comprising Multimeric HSP60 Peptide Carriers
patent-application, October 2009

Protective Vaccine Against Staphylococcus Aureus Biofilms Comprising Cell Wall-Associated Immunogens
patent-application, July 2011

Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance
journal, March 2007

Extraction of the Radioresistant Factor of Micrococcus radiodurans
journal, May 1964

Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance
journal, November 2004

Small-Molecule Antioxidant Proteome-Shields in Deinococcus radiodurans
journal, September 2010

Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection
journal, August 2009

Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn²⁺-Peptide Complex from Deinococcus
journal, July 2012

Radioprotection in E. Coli by an Agent from M. Radiodurans
journal, January 1978

Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans
journal, July 2010

A Manganese Porphyrin Complex is a Novel Radiation Protector
journal, July 2004