Compositions containing nucleosides and manganese and their uses
Abstract
This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.
- Inventors:
- Issue Date:
- Research Org.:
- The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc., Bethesda, MD (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1226548
- Patent Number(s):
- 9186406
- Application Number:
- 12/673,709
- Assignee:
- The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc. (Bethesda, MD)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- FG02-04ER63918
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2008 Aug 18
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses. United States: N. p., 2015.
Web.
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., & Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses. United States.
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Tue .
"Compositions containing nucleosides and manganese and their uses". United States. https://www.osti.gov/servlets/purl/1226548.
@article{osti_1226548,
title = {Compositions containing nucleosides and manganese and their uses},
author = {Daly, Michael J. and Gaidamakova, Elena K. and Matrosova, Vera Y. and Levine, Rodney L. and Wehr, Nancy B.},
abstractNote = {This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {11}
}
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