Compositions containing nucleosides and manganese and their uses

Title: Compositions containing nucleosides and manganese and their uses

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.

Inventors:: Daly, Michael J.; Gaidamakova, Elena K.; Matrosova, Vera Y.; Levine, Rodney L.; Wehr, Nancy B.

Issue Date:: 2015-11-17

OSTI Identifier:: 1226548

Assignee:: The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc. (Bethesda, MD) CHO

Patent Number(s):: 9,186,406

Application Number:: 12/673,709

Contract Number:: FG02-04ER63918

Resource Relation:: Patent File Date: 2008 Aug 18

Research Org:: The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc., Bethesda, MD (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

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