Compositions containing nucleosides and manganese and their uses
Abstract
This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.
- Inventors:
- Issue Date:
- Research Org.:
- The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc., Bethesda, MD (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1226548
- Patent Number(s):
- 9,186,406
- Application Number:
- 12/673,709
- Assignee:
- The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc. (Bethesda, MD)
- DOE Contract Number:
- FG02-04ER63918
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2008 Aug 18
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses. United States: N. p., 2015.
Web.
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., & Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses. United States.
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Tue .
"Compositions containing nucleosides and manganese and their uses". United States. https://www.osti.gov/servlets/purl/1226548.
@article{osti_1226548,
title = {Compositions containing nucleosides and manganese and their uses},
author = {Daly, Michael J. and Gaidamakova, Elena K. and Matrosova, Vera Y. and Levine, Rodney L. and Wehr, Nancy B.},
abstractNote = {This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {11}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Stabilized liquid enzyme composition for glucose determination
patent, January 1990
- Gawronski, Thomas
- US Patent Document 4,897,346
Process for the production on an antiviral vaccine, particularly anti-foot and mouth disease vaccine
patent, September 1990
- Lombardo, Jorge; Smolko, Eduardo; Ugalde, Rodolfo
- US Patent Document 4,959,211
Infant formulas and nutrition products enriched with nucleosides and/or nucleotides and processes for their preparation
patent, November 1991
- Gil, Angel; Morales, Daniel; Valverde, Eduardo
- US Patent Document 5,066,500
Method and apparatus of a defined serumfree medical solution
patent, April 1995
- Lindstrom, Richard; Skelnik, Debra
- US Patent Document 5,407,669
Nutritive medium for the culture of microorganism
patent, July 1996
- Jay, Corinne
- US Patent Document 5,536,645
Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance
journal, March 2007
- Daly, Michael J.; Gaidamakova, Elena K.; Matrosova, Vera Y.
- PLoS Biology, Vol. 5, Issue 4, Article No. e92
Extraction of the Radioresistant Factor of Micrococcus radiodurans
journal, May 1964
- Bruce, A. K.
- Radiation Research, Vol. 22, Issue 1
Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance
journal, November 2004
- Daly, M. J.; Gaidamakova, E. K.; Matrosova, V. Y.
- Science, Vol. 306, Issue 5698, p. 1025-1028
Small-Molecule Antioxidant Proteome-Shields in Deinococcus radiodurans
journal, September 2010
- Daly, Michael J.; Gaidamakova, Elena K.; Matrosova, Vera Y.
- PLoS ONE, Vol. 5, Issue 9, Article No. e12570
Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection
journal, August 2009
- Ding, Ding; Huang, Peng; Sun, Hongying
- Journal of Pharmaceutical and Biomedical Analysis, Vol. 50, Issue 1, p. 79-85
Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn2+-Peptide Complex from Deinococcus
journal, July 2012
- Gaidamakova, Elena K.; Myles, Ian A.; McDaniel, Dennis P.
- Cell Host & Microbe, Vol. 12, Issue 1, p. 117-124
Radioprotection in E. Coli by an Agent from M. Radiodurans
journal, January 1978
- Goldstein, L. S.; Gersten, D. M.; Bruce, A. K.
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 34, Issue 4
Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans
journal, July 2010
- Krisko, A.; Radman, M.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 32, p. 14373-14377
A Manganese Porphyrin Complex is a Novel Radiation Protector
journal, July 2004
- Lee, Jin Hyup; Park, Jeen-Woo
- Free Radical Biology and Medicine, Vol. 37, Issue 2, p. 272-283