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Title: Compositions containing nucleosides and manganese and their uses

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
1226548
Assignee:
The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc. (Bethesda, MD) CHO
Patent Number(s):
9,186,406
Application Number:
12/673,709
Contract Number:
FG02-04ER63918
Resource Relation:
Patent File Date: 2008 Aug 18
Research Org:
The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc., Bethesda, MD (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Works referenced in this record:

Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance
journal, March 2007
  • Daly, Michael J.; Gaidamakova, Elena K.; Matrosova, Vera Y.
  • PLoS Biology, Vol. 5, Issue 4, Article No. e92
  • DOI: 10.1371/journal.pbio.0050092

Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance
journal, November 2004
  • Daly, M. J.; Gaidamakova, E. K.; Matrosova, V. Y.
  • Science, Vol. 306, Issue 5698, p. 1025-1028
  • DOI: 10.1126/science.1103185

Small-Molecule Antioxidant Proteome-Shields in Deinococcus radiodurans
journal, September 2010
  • Daly, Michael J.; Gaidamakova, Elena K.; Matrosova, Vera Y.
  • PLoS ONE, Vol. 5, Issue 9, Article No. e12570
  • DOI: 10.1371/journal.pone.0012570

Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection
journal, August 2009
  • Ding, Ding; Huang, Peng; Sun, Hongying
  • Journal of Pharmaceutical and Biomedical Analysis, Vol. 50, Issue 1, p. 79-85
  • DOI: 10.1016/j.jpba.2009.03.024

Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn2+-Peptide Complex from Deinococcus
journal, July 2012
  • Gaidamakova, Elena K.; Myles, Ian A.; McDaniel, Dennis P.
  • Cell Host & Microbe, Vol. 12, Issue 1, p. 117-124
  • DOI: 10.1016/j.chom.2012.05.011

Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans
journal, July 2010
  • Krisko, A.; Radman, M.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 32, p. 14373-14377
  • DOI: 10.1073/pnas.1009312107

A Manganese Porphyrin Complex is a Novel Radiation Protector
journal, July 2004