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Title: Compositions containing nucleosides and manganese and their uses

Abstract

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc., Bethesda, MD (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1226548
Patent Number(s):
9186406
Application Number:
12/673,709
Assignee:
The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc. (Bethesda, MD)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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DOE Contract Number:  
FG02-04ER63918
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Aug 18
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses. United States: N. p., 2015. Web.
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Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., & Wehr, Nancy B. Compositions containing nucleosides and manganese and their uses. United States.
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Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B. Tue . "Compositions containing nucleosides and manganese and their uses". United States. https://www.osti.gov/servlets/purl/1226548.
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@article{osti_1226548,
title = {Compositions containing nucleosides and manganese and their uses},
author = {Daly, Michael J. and Gaidamakova, Elena K. and Matrosova, Vera Y. and Levine, Rodney L. and Wehr, Nancy B.},
abstractNote = {This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {11}
}
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Works referenced in this record:

Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance
journal, March 2007

Extraction of the Radioresistant Factor of Micrococcus radiodurans
journal, May 1964

Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance
journal, November 2004

Small-Molecule Antioxidant Proteome-Shields in Deinococcus radiodurans
journal, September 2010

Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection
journal, August 2009

Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn2+-Peptide Complex from Deinococcus
journal, July 2012

Radioprotection in E. Coli by an Agent from M. Radiodurans
journal, January 1978

  • Goldstein, L. S.; Gersten, D. M.; Bruce, A. K.
  • International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 34, Issue 4
  • https://doi.org/10.1080/09553007814551011

Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans
journal, July 2010

A Manganese Porphyrin Complex is a Novel Radiation Protector
journal, July 2004

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