Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
Abstract
Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1346066
- Patent Number(s):
- 9587252
- Application Number:
- 14/674,895
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- FG02-02ER63445
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2015 Mar 31
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Church, George M., Esvelt, Kevin, and Mali, Prashant. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. United States: N. p., 2017.
Web.
Church, George M., Esvelt, Kevin, & Mali, Prashant. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. United States.
Church, George M., Esvelt, Kevin, and Mali, Prashant. Tue .
"Orthogonal Cas9 proteins for RNA-guided gene regulation and editing". United States. https://www.osti.gov/servlets/purl/1346066.
@article{osti_1346066,
title = {Orthogonal Cas9 proteins for RNA-guided gene regulation and editing},
author = {Church, George M. and Esvelt, Kevin and Mali, Prashant},
abstractNote = {Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 07 00:00:00 EST 2017},
month = {Tue Mar 07 00:00:00 EST 2017}
}
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