Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
Abstract
Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1998382
- Patent Number(s):
- 11649469
- Application Number:
- 16/411,793
- Assignee:
- President & Fellows of Harvard College (Cambridge, MA)
- DOE Contract Number:
- FG02-02ER63445; P50 HG005550
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 05/14/2019
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Church, George M., Esvelt, Kevin M., and Mali, Prashant G. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. United States: N. p., 2023.
Web.
Church, George M., Esvelt, Kevin M., & Mali, Prashant G. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. United States.
Church, George M., Esvelt, Kevin M., and Mali, Prashant G. Tue .
"Orthogonal Cas9 proteins for RNA-guided gene regulation and editing". United States. https://www.osti.gov/servlets/purl/1998382.
@article{osti_1998382,
title = {Orthogonal Cas9 proteins for RNA-guided gene regulation and editing},
author = {Church, George M. and Esvelt, Kevin M. and Mali, Prashant G.},
abstractNote = {Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2023},
month = {5}
}
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