U.S. Department of EnergyOffice of Scientific and Technical Information
PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection
Abstract
The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host Responses to Understand Severe Human Virus Infections" program project was a highly integrated and comprehensive systems biology research core, funded by the National Institute of Health (U19AI106772) from 2013-06-01 to 2018-05-31, investigating the complex host response to category A, B, and C priority pathogen infections. Resulting project deliverables include an extensive comprehensive collections of linked primary and secondary transformation viral experimental infection data. Here we provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open access to viral Omics lifecycle datasets and project metadata. Using a highly integrated and multidisciplinary approach, linked primary data and metadata supporting secondary normalization datasets, provide critical information necessary for research reproducibility and long-term preservation. Enabling on-demand data access for research community consumption and developer reuse, serves to support new mechanistic insights and discoveries into host-pathogen interactions for aiding future biohazard data preparedness efforts in emergency response to global health crises involving viral infection.
- Authors:
-
;
;
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Pacific Northwest National Laboratory, Biological Sciences Division
- Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Publication Date:
- Other Number(s):
- PRJ.U19AI106772
LHVFLU; LHVEBOV; LHVWNV; LHVMERS; LHVIFN
- DOE Contract Number:
- AC05-76RL01830
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
- Collaborations:
- Modeling Host Responses to Understand Severe Human Virus Infections Program Project
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; BioProject Accession Number [NCIT:C175890]; Dataset Collection [schema:DataCatalog]; Ebolavirus [NCBITAXON:186536]; Gene expression profile data [edam.data:0928]; Human Interferon [NCIT:C20493]; Human virus [NCIT:C14317]; Immune Response [GO:0006955]; Influenza A virus [NCBITAXON:11320]; MERS-CoV [NCBITAXON:1335626]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Multi-omics [edam.topic:4021]; Omics [edam.topic:3391]; Time Sampled Measurement Datasets [IAO:0000584]; Virology [edam.topic:0781]; West Nile virus [NCBITAXON:11082]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]
- OSTI Identifier:
- 1971764
- DOI:
- https://doi.org/10.25584/PRJ.U19AI106772/1971764
Citation Formats
Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection. United States: N. p., 2023.
Web. doi:10.25584/PRJ.U19AI106772/1971764.
Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection. United States. doi:https://doi.org/10.25584/PRJ.U19AI106772/1971764
Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2023.
"PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection". United States. doi:https://doi.org/10.25584/PRJ.U19AI106772/1971764. https://www.osti.gov/servlets/purl/1971764. Pub date:Mon Jan 30 04:00:00 UTC 2023
@article{osti_1971764,
title = {PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection},
author = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},
abstractNote = {The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host Responses to Understand Severe Human Virus Infections" program project was a highly integrated and comprehensive systems biology research core, funded by the National Institute of Health (U19AI106772) from 2013-06-01 to 2018-05-31, investigating the complex host response to category A, B, and C priority pathogen infections. Resulting project deliverables include an extensive comprehensive collections of linked primary and secondary transformation viral experimental infection data. Here we provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open access to viral Omics lifecycle datasets and project metadata. Using a highly integrated and multidisciplinary approach, linked primary data and metadata supporting secondary normalization datasets, provide critical information necessary for research reproducibility and long-term preservation. Enabling on-demand data access for research community consumption and developer reuse, serves to support new mechanistic insights and discoveries into host-pathogen interactions for aiding future biohazard data preparedness efforts in emergency response to global health crises involving viral infection.},
doi = {10.25584/PRJ.U19AI106772/1971764},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 30 04:00:00 UTC 2023},
month = {Mon Jan 30 04:00:00 UTC 2023}
}