PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection

Anderson, Lindsey N.; Eisfeld, Amie J.; Waters, Katrina M.

doi:10.25584/PRJ.U19AI106772/1971764

Title: PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection

Abstract

The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host Responses to Understand Severe Human Virus Infections" program project was a highly integrated and comprehensive systems biology research core, funded by the National Institute of Health (U19AI106772) from 2013-06-01 to 2018-05-31, investigating the complex host response to category A, B, and C priority pathogen infections. Resulting project deliverables include an extensive comprehensive collections of linked primary and secondary transformation viral experimental infection data. Here we provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open access to viral Omics lifecycle datasets and project metadata. Using a highly integrated and multidisciplinary approach, linked primary data and metadata supporting secondary normalization datasets, provide critical information necessary for research reproducibility and long-term preservation. Enabling on-demand data access for research community consumption and developer reuse, serves to support new mechanistic insights and discoveries into host-pathogen interactions for aiding future biohazard data preparedness efforts in emergency response to global health crises involving viral infection.

Authors:

;

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department

Publication Date:: Mon Jan 30 00:00:00 EST 2023

Other Number(s):: PRJ.U19AI106772
LHVFLU;LHVEBOV;LHVWNV;LHVMERS;LHVIFN

DOE Contract Number:: AC05-76RL01830

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:: Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Keywords:: Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human Interferon [NCIT:C20493]; Human virus [NCIT:C14317]; Influenza A virus [NCBITAXON:11320]; Ebolavirus [NCBITAXON:186536]; West Nile virus [NCBITAXON:11082]; MERS-CoV [NCBITAXON:1335626]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Dataset Collection [schema:DataCatalog]

OSTI Identifier:: 1971764

DOI:: https://doi.org/10.25584/PRJ.U19AI106772/1971764

Citation Formats


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection.  United States: N. p., 2023. 
        Web.  doi:10.25584/PRJ.U19AI106772/1971764.

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                    Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection.  United States.  doi:https://doi.org/10.25584/PRJ.U19AI106772/1971764

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                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2023.  
"PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection".  United States.  doi:https://doi.org/10.25584/PRJ.U19AI106772/1971764.  https://www.osti.gov/servlets/purl/1971764. Pub date:Mon Jan 30 00:00:00 EST 2023

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@article{osti_1971764,

  title        = {PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection},

  author       = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},

  abstractNote = {The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host Responses to Understand Severe Human Virus Infections" program project was a highly integrated and comprehensive systems biology research core, funded by the National Institute of Health (U19AI106772) from 2013-06-01 to 2018-05-31, investigating the complex host response to category A, B, and C priority pathogen infections. Resulting project deliverables include an extensive comprehensive collections of linked primary and secondary transformation viral experimental infection data. Here we provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open access to viral Omics lifecycle datasets and project metadata. Using a highly integrated and multidisciplinary approach, linked primary data and metadata supporting secondary normalization datasets, provide critical information necessary for research reproducibility and long-term preservation. Enabling on-demand data access for research community consumption and developer reuse, serves to support new mechanistic insights and discoveries into host-pathogen interactions for aiding future biohazard data preparedness efforts in emergency response to global health crises involving viral infection.},

  doi          = {10.25584/PRJ.U19AI106772/1971764},

  journal      = {},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {Mon Jan 30 00:00:00 EST 2023},

  month        = {Mon Jan 30 00:00:00 EST 2023}

}

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DOI: https://doi.org/10.25584/PRJ.U19AI106772/1971764

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Works referenced in this record:

PNNL DataHub Project Omics-LHV Profiling of Host Response to Ebola Infection Post-Processed Data Package DOIs
dataset, January 2021

Anderson, Lindsey; McDermott, Jason; Waters, Katrina
Pacific Northwest National Laboratory 2; PNNL
https://doi.org/10.25584/LHVEBOV/1784282

PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Interferon-Stimulated Response to Virus Infection, Processed Experimental Dataset Catalog
dataset, January 2021

Anderson, Lindsey; McDermott, Jason; Waters, Katrina
Pacific Northwest National Laboratory 2; PNNL
https://doi.org/10.25584/LHVIFN/1786979

Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog
dataset, January 2021

Anderson, Lindsey; McDermott, Jason; Waters, Katrina
Pacific Northwest National Laboratory 2; PNNL
https://doi.org/10.25584/LHVMERS/1813911

PNNL DataHub Project Omics-LHV Profiling of Host Response to Influenza Infection Post-Processed Data Package DOIs
dataset, January 2021

Anderson, Lindsey; McDermott, Jason; Waters, Katrina
Pacific Northwest National Laboratory 2; PNNL
https://doi.org/10.25584/LHVFLU/1773428

PNNL DataHub Omics Lethal Human Viruses Project, Modeling Host Responses to West Nile Infection Post-Processed Data Package DOIs
dataset, January 2021

Anderson, Lindsey; McDermott, Jason; Waters, Katrina
Pacific Northwest National Laboratory 2; PNNL
https://doi.org/10.25584/LHVWNV/1784305

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Title: PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection

Abstract

Citation Formats

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