Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog

Anderson, Lindsey N.; Eisfeld, Amie J.; Waters, Katrina M.

doi:10.25584/LHVMERS/1813911

Title: Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog

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Abstract

Middle East Respiratory Syndrome coronavirus (MERS-CoV) is classified as a Category C priority pathogen (Coronaviridae) by the National Institute of Allergy and Infectious Diseases (NIAID), and is known to cause severe respiratory disease with high mortality rates in humans. Lethal host-pathogen invasion mechanisms and the cellular intricacies behind these fatal infections still remain unclear. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L), and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV [NCBITAXON:1335626] experimental infection study. Host sample types include human lungmore »« less

Authors:

;

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department

Publication Date:: Mon Jan 18 00:00:00 EST 2021

Other Number(s):: LHVMERS
MCL001;MCL002;MCL003;MCL004;MCL005;MDC001;MFB001;MFB002;MFB003;MHAE001;MHAE002;MHAE003;MM001;MMVE001;MMVE002;MMVE003

DOE Contract Number:: AC05-76RL01830

Research Org.:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:: Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Keywords:: Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human virus [NCIT:C14317]; MERS-CoV [NCBITAXON:1335626]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Dataset Collection [schema:DataCatalog]

OSTI Identifier:: 1813911

DOI:: https://doi.org/10.25584/LHVMERS/1813911

Citation Formats


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog.  United States: N. p., 2021. 
        Web.  doi:10.25584/LHVMERS/1813911.

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                    Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog.  United States.  doi:https://doi.org/10.25584/LHVMERS/1813911

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                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021.  
"Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog".  United States.  doi:https://doi.org/10.25584/LHVMERS/1813911.  https://www.osti.gov/servlets/purl/1813911. Pub date:Mon Jan 18 00:00:00 EST 2021

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@article{osti_1813911,

  title        = {Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog},

  author       = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},

  abstractNote = {Middle East Respiratory Syndrome coronavirus (MERS-CoV) is classified as a Category C priority pathogen (Coronaviridae) by the National Institute of Allergy and Infectious Diseases (NIAID), and is known to cause severe respiratory disease with high mortality rates in humans. Lethal host-pathogen invasion mechanisms and the cellular intricacies behind these fatal infections still remain unclear. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L), and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV [NCBITAXON:1335626] experimental infection study. Host sample types include human lung adenocarcinoma cells ["Calu-3", BTO:0002750], human bronchial epithelial cells ["Calu-3 clone 2B4"; BTO:0002022], primary human fibroblasts ["FB"; BTO:0000452], primary human airway epithelial cells ["HAE"; BTO:0005571], human microvascular endothelial cells ["HMVE"; BTO:0003123], and whole mouse lung [BTO:0000763] tissue collections.},

  doi          = {10.25584/LHVMERS/1813911},

  journal      = {},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {Mon Jan 18 00:00:00 EST 2021},

  month        = {Mon Jan 18 00:00:00 EST 2021}

}

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DOI: https://doi.org/10.25584/LHVMERS/1813911

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