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Title: Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001

Abstract

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS) and icMERS-CoV mutants icMERS-CoV-RFP, icMERS-CoV-dNSP16, icMERS-CoV-d4B, and icMERS-CoV-d3 virus infection. Sample data was obtained from human bronchial epithelial cells (Calu-3 clone 2B4) for mRNA and miRNA transcriptome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

Authors:
ORCiD logo ; ORCiD logo ; ORCiD logo
  1. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
  2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
Publication Date:
Other Number(s):
MCL001
NCBI BioProject: PRJNA274404;GEO Series: GSE65574 (GEO Series;mRNA and miRNA)
DOE Contract Number:  
AC05-76RL01830
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
Collaborations:
Modeling Host Responses to Understand Severe Human Virus Infections Program Project
Subject:
59 BASIC BIOLOGICAL SCIENCES
Keywords:
Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human virus [NCIT:C14317]; Middle East respiratory syndrome-related coronavirus [NCBITAXON:1335626]; Time Sampled Measurement Datasets [IAO:0000584]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Data Download [schema:DataDownload]
OSTI Identifier:
1661931
DOI:
https://doi.org/10.25584/LHVMCL001/1661931

Citation Formats

Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001. United States: N. p., 2021. Web. doi:10.25584/LHVMCL001/1661931.
Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001. United States. doi:https://doi.org/10.25584/LHVMCL001/1661931
Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021. "Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001". United States. doi:https://doi.org/10.25584/LHVMCL001/1661931. https://www.osti.gov/servlets/purl/1661931. Pub date:Mon Jan 18 00:00:00 EST 2021
@article{osti_1661931,
title = {Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001},
author = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},
abstractNote = {The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS) and icMERS-CoV mutants icMERS-CoV-RFP, icMERS-CoV-dNSP16, icMERS-CoV-d4B, and icMERS-CoV-d3 virus infection. Sample data was obtained from human bronchial epithelial cells (Calu-3 clone 2B4) for mRNA and miRNA transcriptome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.},
doi = {10.25584/LHVMCL001/1661931},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {1}
}