Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001

Anderson, Lindsey N.; Eisfeld, Amie J.; Waters, Katrina M.

doi:10.25584/LHVMCL001/1661931

Title: Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001

Dataset
Other Related Research

Abstract

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS) and icMERS-CoV mutants icMERS-CoV-RFP, icMERS-CoV-dNSP16, icMERS-CoV-d4B, and icMERS-CoV-d3 virus infection. Sample data was obtained from human bronchial epithelial cells (Calu-3 clone 2B4) for mRNA and miRNA transcriptome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

Authors:

;

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Pacific Northwest National Laboratory, Biological Sciences Division
Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Publication Date:: Mon Jan 18 04:00:00 UTC 2021

Other Number(s):: MCL001
NCBI BioProject: PRJNA274404; GEO Series: GSE65574 (GEO Series; mRNA and miRNA)

DOE Contract Number:: AC05-76RL01830

Research Org.:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:: Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:: 59 BASIC BIOLOGICAL SCIENCES; BioProject Accession Number [NCIT:C175890]; Data Download [schema:DataDownload]; Gene expression profile data [edam.data:0928]; Human virus [NCIT:C14317]; Immune Response [GO:0006955]; Middle East respiratory syndrome-related coronavirus [NCBITAXON:1335626]; Multi-omics [edam.topic:4021]; Omics [edam.topic:3391]; Time Sampled Measurement Datasets [IAO:0000584]; Virology [edam.topic:0781]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]

OSTI Identifier:: 1661931

DOI:: https://doi.org/10.25584/LHVMCL001/1661931

Citation Formats


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001.  United States: N. p., 2021. 
        Web.  doi:10.25584/LHVMCL001/1661931.

Copy to clipboard


                    Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001.  United States.  doi:https://doi.org/10.25584/LHVMCL001/1661931

Copy to clipboard


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021.  
"Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001".  United States.  doi:https://doi.org/10.25584/LHVMCL001/1661931.  https://www.osti.gov/servlets/purl/1661931. Pub date:Mon Jan 18 04:00:00 UTC 2021

Copy to clipboard


                    
@article{osti_1661931,

  title        = {Omics-Lethal Human Viruses, MERS-CoV Experiment MCL001},

  author       = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},

  abstractNote = {The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS) and icMERS-CoV mutants icMERS-CoV-RFP, icMERS-CoV-dNSP16, icMERS-CoV-d4B, and icMERS-CoV-d3 virus infection. Sample data was obtained from human bronchial epithelial cells (Calu-3 clone 2B4) for mRNA and miRNA transcriptome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.},

  doi          = {10.25584/LHVMCL001/1661931},

  journal      = {},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {Mon Jan 18 04:00:00 UTC 2021},

  month        = {Mon Jan 18 04:00:00 UTC 2021}

}

Copy to clipboard

Dataset:

View Dataset

DOI: https://doi.org/10.25584/LHVMCL001/1661931

Save / Share:

Export Metadata

Save to My Library

Similar records in DOE Data Explorer and OSTI.GOV collections:

Omics-Lethal Human Viruses, MERS-CoV Experiment MCL002

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS) and icMERS-CoV mutants icMERS-RFP, icMERS-DNSP16, and icMERS-d4B virus infection. Sample data was obtained from human bronchial epithelial cells (Calu-3 clone 2B4) for proteome, metabolome, and lipidome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, and lipidomics dataset download each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.
Omics-Lethal Human Viruses, MERS-CoV Experiment MFB001

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the human host response to wild-type MERS-CoV (icMERS-CoV) virus infection. Sample data was obtained from primary human fibroblasts and processed for mRNA, miRNA, proteomics, metabolomics, and lipidomics expression analysis. econdary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.
Omics-Lethal Human Viruses, MERS-CoV Experiment MFB002

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) and mutant virus infection. Sample data was obtained from primary human fibroblasts for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.
Omics-Lethal Human Viruses, MERS-CoV Experiment MFB003

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) virus infection. Sample data was obtained from primary human fibroblasts for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.
Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE001

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) virus infection. Sample data was obtained from human airway epithelial cells for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

Similar Records