Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE001

Anderson, Lindsey N.; Eisfeld, Amie J.; Waters, Katrina M.

doi:10.25584/LHVMHAE001/1661938

Title: Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE001

Abstract

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) virus infection. Sample data was obtained from human airway epithelial cells for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

Authors:

;

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department

Publication Date:: Mon Jan 18 00:00:00 EST 2021

Other Number(s):: MHAE001
NCBI BioProject: PRJNA323377 (mRNA);NCBI BioProject: PRJNA323378 (miRNA);GEO Series: GSE81909 (mRNA);GEO Series: GSE81852 (miRNA);MassIVE: MSV000083533 (lipidome);MassIVE: MSV000081889 (metabolome);MassIVE: MSV000083529 (proteome)

DOE Contract Number:: AC05-76RL01830

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:: Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Keywords:: Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human virus [NCIT:C14317]; Middle East respiratory syndrome-related coronavirus [NCBITAXON:1335626]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Data Download [schema:DataDownload]

OSTI Identifier:: 1661938

DOI:: https://doi.org/10.25584/LHVMHAE001/1661938

Citation Formats


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE001.  United States: N. p., 2021. 
        Web.  doi:10.25584/LHVMHAE001/1661938.

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                    Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE001.  United States.  doi:https://doi.org/10.25584/LHVMHAE001/1661938

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                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021.  
"Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE001".  United States.  doi:https://doi.org/10.25584/LHVMHAE001/1661938.  https://www.osti.gov/servlets/purl/1661938. Pub date:Mon Jan 18 00:00:00 EST 2021

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@article{osti_1661938,

  title        = {Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE001},

  author       = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},

  abstractNote = {The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) virus infection. Sample data was obtained from human airway epithelial cells for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.},

  doi          = {10.25584/LHVMHAE001/1661938},

  journal      = {},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {Mon Jan 18 00:00:00 EST 2021},

  month        = {Mon Jan 18 00:00:00 EST 2021}

}

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DOI: https://doi.org/10.25584/LHVMHAE001/1661938

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Works referenced in this record:

Hypergraph models of biological networks to identify genes critical to pathogenic viral response
journal, May 2021

Feng, Song; Heath, Emily; Jefferson, Brett
BMC Bioinformatics, Vol. 22, Issue 1
https://doi.org/10.1186/s12859-021-04197-2

Works referencing / citing this record:

Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog
dataset, January 2021

Anderson, Lindsey; McDermott, Jason; Waters, Katrina
Pacific Northwest National Laboratory 2; PNNL
https://doi.org/10.25584/LHVMERS/1813911

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Title: Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE001

Abstract

Citation Formats

Hypergraph models of biological networks to identify genes critical to pathogenic viral response journal, May 2021

Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog dataset, January 2021

Hypergraph models of biological networks to identify genes critical to pathogenic viral response
journal, May 2021

Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog
dataset, January 2021