Omics-Lethal Human Viruses, MERS-CoV Experiment MCL002

Anderson, Lindsey N.; Eisfeld, Amie J.; Waters, Katrina M.

doi:10.25584/LHVMCL002/1661933

Title: Omics-Lethal Human Viruses, MERS-CoV Experiment MCL002

Abstract

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS) and icMERS-CoV mutants icMERS-RFP, icMERS-DNSP16, and icMERS-d4B virus infection. Sample data was obtained from human bronchial epithelial cells (Calu-3 clone 2B4) for proteome, metabolome, and lipidome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, and lipidomics dataset download each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

Authors:

;

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department

Publication Date:: 2021-01-18

Other Number(s):: MCL002
MassIVE: MSV000080025 (proteome);MassIVE: MSV000080022 (metabolome);MassIVE: MSV000081045 (lipidome)

DOE Contract Number:: AC05-76RL01830

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:: Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Keywords:: Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human virus [NCIT:C14317]; Middle East respiratory syndrome-related coronavirus [NCBITAXON:1335626]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Data Download [schema:DataDownload]

OSTI Identifier:: 1661933

DOI:: https://doi.org/10.25584/LHVMCL002/1661933

Citation Formats


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. Omics-Lethal Human Viruses, MERS-CoV Experiment MCL002.  United States: N. p., 2021. 
        Web.  doi:10.25584/LHVMCL002/1661933.

Copy to clipboard


                    Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. Omics-Lethal Human Viruses, MERS-CoV Experiment MCL002.  United States.  doi:https://doi.org/10.25584/LHVMCL002/1661933

Copy to clipboard


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021.  
"Omics-Lethal Human Viruses, MERS-CoV Experiment MCL002".  United States.  doi:https://doi.org/10.25584/LHVMCL002/1661933.  https://www.osti.gov/servlets/purl/1661933. Pub date:Mon Jan 18 00:00:00 EST 2021

Copy to clipboard


                    
@article{osti_1661933,

  title        = {Omics-Lethal Human Viruses, MERS-CoV Experiment MCL002},

  author       = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},

  abstractNote = {The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS) and icMERS-CoV mutants icMERS-RFP, icMERS-DNSP16, and icMERS-d4B virus infection. Sample data was obtained from human bronchial epithelial cells (Calu-3 clone 2B4) for proteome, metabolome, and lipidome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, and lipidomics dataset download each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.},

  doi          = {10.25584/LHVMCL002/1661933},

  journal      = {},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {2021},

  month        = {1}

}

Copy to clipboard

Dataset:

View Dataset

DOI: https://doi.org/10.25584/LHVMCL002/1661933

Save / Share:

Export Metadata

Save to My Library

Works referencing / citing this record:

Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog
dataset, January 2021

Anderson, Lindsey; McDermott, Jason; Waters, Katrina
Pacific Northwest National Laboratory 2; PNNL
https://doi.org/10.25584/LHVMERS/1813911

Similar records in DOE Data Explorer and OSTI.GOV collections:

Omics-Lethal Human Viruses, MERS-CoV Experiment MFB001

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the human host response to wild-type MERS-CoV (icMERS-CoV) virus infection. Sample data was obtained from primary human fibroblasts and processed for mRNA, miRNA, proteomics, metabolomics, and lipidomics expression analysis. econdary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.
Omics-Lethal Human Viruses, MERS-CoV Experiment MFB002

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) and mutant virus infection. Sample data was obtained from primary human fibroblasts for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.
Omics-Lethal Human Viruses, MERS-CoV Experiment MFB003

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) virus infection. Sample data was obtained from primary human fibroblasts for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.
Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE001

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) virus infection. Sample data was obtained from human airway epithelial cells for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.
Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE002

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) virus infection. Sample data was obtained from human microvascular endothelial cells for mRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

Similar Records

Title: Omics-Lethal Human Viruses, MERS-CoV Experiment MCL002

Abstract

Citation Formats

Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog dataset, January 2021

Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog
dataset, January 2021