Title: PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Interferon-Stimulated Response to Virus Infection, Processed Experimental Dataset Catalog

Abstract

Human Interferon (IFN) alpha, beta, and gamma participate in the body's natural immune response to lethal virus infection and disease.The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013 - 2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific Human Interferon (IFN), interferon alpha (IFNα), interferon beta (IFNβ), and/or interferon gamma (IFNγ) stimulated response tomore » an experimental virus infection treatment study. Host sample types include cerebellum ["CB", BTO:0000232], cortical neurons ["CN", BTO:0004102], cortex ["CT", BTO:0000233], dendritic cells ["DC", BTO:0002042], granule cell neurons ["GCN", BTO:0003393], lymph node ["LN", BTO:0000784], and serum ["SE", BTO:0001239] from mouse (Mus musculus) tissue collections.« less

Authors:

Anderson, Lindsey N. ;

• Search DOE Data Explorer for author "Anderson, Lindsey N."
• Search DOE Data Explorer for ORCID "0000-0002-8741-7823"

Eisfeld, Amie J. ;

• Search DOE Data Explorer for author "Eisfeld, Amie J."
• Search DOE Data Explorer for ORCID "0000-0003-2231-3107"

Waters, Katrina M.

• Search DOE Data Explorer for author "Waters, Katrina M."
• Search DOE Data Explorer for ORCID "0000-0003-4696-5396"

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+ Show Author Affiliations

1. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department

Publication Date:

Mon Jan 18 00:00:00 EST 2021

Other Number(s):

LHVIFN
IFNaCL001;IFNaHUH001;IFNaIHH001;IFNFB001;IFNMVE001

DOE Contract Number:  

AC05-76RL01830

Research Org.:

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:

USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:

Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:

59 BASIC BIOLOGICAL SCIENCES

Keywords:

Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human Interferon [NCIT:C20493]; Interferon Alpha [NCIT:C20494]; Interferon Beta [NCIT:C20495]; Interferon Gamma [NCIT:C20496]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Dataset Collection [schema:DataCatalog]

OSTI Identifier:

1786979

DOI:

https://doi.org/10.25584/LHVIFN/1786979