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Title: PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Influenza A Virus Infection, Processed Experimental Dataset Catalog

Abstract

Influenza A virus (IAV) is a high risk biological agent, classified as a Category C priority pathogen (Orthomyxoviridae) by the National Institute of Allergy and Infectious Diseases (NIAID), and is known to cause severe respiratory disease with high mortality rates in humans. Lethal host-pathogen invasion mechanisms and the cellular intricacies behind these fatal infections still remain unclear. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L), and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific Influenza A virus [NCBITAXON:11320] experimental infection study. Hostmore » sample types include human lung adenocarcinoma cells ["Calu-3", BTO:0002750] and whole mouse lung [BTO:0000763] tissue collections.« less

Authors:
ORCiD logo ; ORCiD logo ; ORCiD logo
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
Publication Date:
Other Number(s):
LHVFLU
ICL102;ICL103;ICL104;ICL105;ICL106;IM101;IM102;IM103
DOE Contract Number:  
AC05-76RL01830
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
Collaborations:
Modeling Host Responses to Understand Severe Human Virus Infections Program Project
Subject:
59 BASIC BIOLOGICAL SCIENCES
Keywords:
Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human virus [NCIT:C14317]; Influenza A virus [NCBITAXON:11320]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Dataset Collection [schema:DataCatalog]
OSTI Identifier:
1773428
DOI:
https://doi.org/10.25584/LHVFLU/1773428

Citation Formats

Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Influenza A Virus Infection, Processed Experimental Dataset Catalog. United States: N. p., 2021. Web. doi:10.25584/LHVFLU/1773428.
Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Influenza A Virus Infection, Processed Experimental Dataset Catalog. United States. doi:https://doi.org/10.25584/LHVFLU/1773428
Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021. "PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Influenza A Virus Infection, Processed Experimental Dataset Catalog". United States. doi:https://doi.org/10.25584/LHVFLU/1773428. https://www.osti.gov/servlets/purl/1773428. Pub date:Mon Jan 18 00:00:00 EST 2021
@article{osti_1773428,
title = {PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Influenza A Virus Infection, Processed Experimental Dataset Catalog},
author = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},
abstractNote = {Influenza A virus (IAV) is a high risk biological agent, classified as a Category C priority pathogen (Orthomyxoviridae) by the National Institute of Allergy and Infectious Diseases (NIAID), and is known to cause severe respiratory disease with high mortality rates in humans. Lethal host-pathogen invasion mechanisms and the cellular intricacies behind these fatal infections still remain unclear. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L), and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific Influenza A virus [NCBITAXON:11320] experimental infection study. Host sample types include human lung adenocarcinoma cells ["Calu-3", BTO:0002750] and whole mouse lung [BTO:0000763] tissue collections.},
doi = {10.25584/LHVFLU/1773428},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {1}
}

Works referenced in this record:

Im101
dataset, January 2020


Im102
dataset, January 2020


Icl102
dataset, January 2020


Icl106
dataset, January 2020


Icl104
dataset, January 2020


Icl105
dataset, January 2020


Icl103
dataset, January 2020


Im103
dataset, January 2020