PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to West Nile Virus Infection, Processed Experimental Dataset Catalog (in EN)
Abstract
West Nile virus (WNV) is classified as a Category B priority pathogen (mosquito-borne Flavivirus) by the National Institute of Allergy and Infectious Diseases (NIAID), and are known to cause severe infections in humans where lethal host-associated mechanisms are not clearly defined. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013 - 2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L),more »
- Authors:
-
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
- Publication Date:
- Other Number(s):
- LHVWNV
WCB001;WCN002;WCN003;WCT001;WDC010;WDC011;WGCN002;WGCN003;WLN002;WLN003;WSE001
- DOE Contract Number:
- AC05-76RL01830
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
- Collaborations:
- Modeling Host Responses to Understand Severe Human Virus Infections Program Project
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
- Keywords:
- Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human virus [NCIT:C14317]; West Nile virus [NCBITAXON:11082]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Dataset Collection [schema:DataCatalog]
- OSTI Identifier:
- 1784305
- DOI:
- https://doi.org/10.25584/LHVWNV/1784305
Citation Formats
Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to West Nile Virus Infection, Processed Experimental Dataset Catalog. United States: N. p., 2021.
Web. doi:10.25584/LHVWNV/1784305.
Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to West Nile Virus Infection, Processed Experimental Dataset Catalog. United States. doi:https://doi.org/10.25584/LHVWNV/1784305
Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021.
"PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to West Nile Virus Infection, Processed Experimental Dataset Catalog". United States. doi:https://doi.org/10.25584/LHVWNV/1784305. https://www.osti.gov/servlets/purl/1784305. Pub date:Mon Jan 18 00:00:00 EST 2021
@article{osti_1784305,
title = {PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to West Nile Virus Infection, Processed Experimental Dataset Catalog},
author = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},
abstractNote = {West Nile virus (WNV) is classified as a Category B priority pathogen (mosquito-borne Flavivirus) by the National Institute of Allergy and Infectious Diseases (NIAID), and are known to cause severe infections in humans where lethal host-associated mechanisms are not clearly defined. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013 - 2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L), and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding a specific West Nile virus [NCBITAXON:11082] (WNV-NY99 382) experimental infection study. Host sample types include cerebellum ["CB", BTO:0000232], cortical neurons ["CN", BTO:0004102], cortex ["CT", BTO:0000233], dendritic cells ["DC", BTO:0002042], granule cell neurons ["GCN", BTO:0003393], lymph node ["LN", BTO:0000784], and serum ["SE", BTO:0001239] from mouse (Mus musculus) tissue collections.},
doi = {10.25584/LHVWNV/1784305},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {1}
}
Works referenced in this record:
Wln003
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL
Wgcn003
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL
Wcb001
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL
Wgcn002
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL
Wcn002
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL
Wcn003
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL
Wse001
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL
Wln002
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL
Wct001
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL
FAIRsharing record for: Mass Spectrometry Virtual Interactive Environment
dataset, January 2018
- Team, FAIRsharing
- FAIRsharing
Hypergraph models of biological networks to identify genes critical to pathogenic viral response
journal, May 2021
- Feng, Song; Heath, Emily; Jefferson, Brett
- BMC Bioinformatics, Vol. 22, Issue 1
Wdc010
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL
Wdc011
dataset, January 2020
- Waters, Katrina; Anderson, Lindsey; McDermott, Jason
- Pacific Northwest National Laboratory 2; EMSL; PNNL