Title: PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to West Nile Virus Infection, Processed Experimental Dataset Catalog

Abstract

West Nile virus (WNV) is classified as a Category B priority pathogen (mosquito-borne Flavivirus) by the National Institute of Allergy and Infectious Diseases (NIAID), and are known to cause severe infections in humans where lethal host-associated mechanisms are not clearly defined. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013 - 2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L),more » and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding a specific West Nile virus [NCBITAXON:11082] (WNV-NY99 382) experimental infection study. Host sample types include cerebellum ["CB", BTO:0000232], cortical neurons ["CN", BTO:0004102], cortex ["CT", BTO:0000233], dendritic cells ["DC", BTO:0002042], granule cell neurons ["GCN", BTO:0003393], lymph node ["LN", BTO:0000784], and serum ["SE", BTO:0001239] from mouse (Mus musculus) tissue collections.« less

Authors:

Anderson, Lindsey N. ;

• Search DOE Data Explorer for author "Anderson, Lindsey N."
• Search DOE Data Explorer for ORCID "0000-0002-8741-7823"

Eisfeld, Amie J. ;

• Search DOE Data Explorer for author "Eisfeld, Amie J."
• Search DOE Data Explorer for ORCID "0000-0003-2231-3107"

Waters, Katrina M.

• Search DOE Data Explorer for author "Waters, Katrina M."
• Search DOE Data Explorer for ORCID "0000-0003-4696-5396"

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+ Show Author Affiliations

1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department

Publication Date:

2021-01-18

Other Number(s):

LHVWNV
WCB001;WCN002;WCN003;WCT001;WDC010;WDC011;WGCN002;WGCN003;WLN002;WLN003;WSE001

DOE Contract Number:  

AC05-76RL01830

Research Org.:

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:

USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:

Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:

59 BASIC BIOLOGICAL SCIENCES

Keywords:

Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human virus [NCIT:C14317]; West Nile virus [NCBITAXON:11082]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Dataset Collection [schema:DataCatalog]

OSTI Identifier:

1784305

DOI:

https://doi.org/10.25584/LHVWNV/1784305