PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Ebola Virus Infection, Processed Experimental Dataset Catalog

Anderson, Lindsey N.; Eisfeld, Amie J.; Waters, Katrina M.

doi:10.25584/LHVEBOV/1784282

Title: PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Ebola Virus Infection, Processed Experimental Dataset Catalog

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Abstract

Ebola virus (EBOV) is high risk biological agent, classified as a Category A priority pathogen (Flaviviridae) by the National Institute of Allergy and Infectious Diseases (NIAID), known to cause hemorrhagic fever with high mortality rates in humans. Lethal host-pathogen invasion mechanisms and the cellular intricacies behind these fatal infections still remain unclear. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L), and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific Ebola virus [NCBITAXON:186536] (Zaire/Makona or Zaire/Mayinga) experimental infection study. Human host samples types include peripheral blood mononuclear cellsmore »« less

Authors:

;

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Pacific Northwest National Laboratory, Biological Sciences Division
Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Publication Date:: Sun Jan 17 23:00:00 EST 2021

Other Number(s):: LHVEBOV
EH001; EHUH001; EHUH002; EHUH003; EHUVEC001; EIHH001; EIHH002; EU937001

DOE Contract Number:: AC05-76RL01830

Research Org.:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:: Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:: 59 BASIC BIOLOGICAL SCIENCES; BioProject Accession Number [NCIT:C175890]; Dataset Collection [schema:DataCatalog]; Ebolavirus [NCBITAXON:186536]; Gene expression profile data [edam.data:0928]; Human virus [NCIT:C14317]; Immune Response [GO:0006955]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Multi-omics [edam.topic:4021]; Omics [edam.topic:3391]; Time Sampled Measurement Datasets [IAO:0000584]; Virology [edam.topic:0781]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]

OSTI Identifier:: 1784282

DOI:: https://doi.org/10.25584/LHVEBOV/1784282

Citation Formats


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Ebola Virus Infection, Processed Experimental Dataset Catalog.  United States: N. p., 2021. 
        Web.  doi:10.25584/LHVEBOV/1784282.

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                    Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Ebola Virus Infection, Processed Experimental Dataset Catalog.  United States.  doi:https://doi.org/10.25584/LHVEBOV/1784282

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                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021.  
"PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Ebola Virus Infection, Processed Experimental Dataset Catalog".  United States.  doi:https://doi.org/10.25584/LHVEBOV/1784282.  https://www.osti.gov/servlets/purl/1784282. Pub date:Sun Jan 17 23:00:00 EST 2021

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@article{osti_1784282,

  title        = {PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Ebola Virus Infection, Processed Experimental Dataset Catalog},

  author       = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},

  abstractNote = {Ebola virus (EBOV) is high risk biological agent, classified as a Category A priority pathogen (Flaviviridae) by the National Institute of Allergy and Infectious Diseases (NIAID), known to cause hemorrhagic fever with high mortality rates in humans. Lethal host-pathogen invasion mechanisms and the cellular intricacies behind these fatal infections still remain unclear. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation)  quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L), and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific Ebola virus [NCBITAXON:186536] (Zaire/Makona or Zaire/Mayinga) experimental infection study. Human host samples types include peripheral blood mononuclear cells isolated from blood plasma ["PBMC", BTO:0001025], human hepatoma carcinoma cells ["HUH", BTO:0001950], human umbilical vein endothelial cells ["HUVEC", BTO:0001949], immortalized human hepatocyte cells ["IHH", BTO:0006147], and human histiocytic lymphoma cells ["U937", BTO:0001412]. },

  doi          = {10.25584/LHVEBOV/1784282},

  journal      = {},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {Sun Jan 17 23:00:00 EST 2021},

  month        = {Sun Jan 17 23:00:00 EST 2021}

}

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DOI: https://doi.org/10.25584/LHVEBOV/1784282

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