MPCVD-Grown Nanodiamond Microelectrodes with Oxygen Plasma Activation for Neurochemical Applications
Abstract
Nanodiamonds (NDs) are a carbon nanomaterial that has a diamond core with heteroatoms and defects at the surface. The large surface area, defect sites, and functional groups on NDs make them a promising material for electrochemical sensing. Previously, we dip-coated ND onto carbon-fiber microelectrodes (CFMEs) and found increases in sensitivity, but the coating was sparse. Here, for this work, we directly grew thin films of ND on niobium wires using microwave plasma chemical vapor deposition (MP-CVD) to provide full surface coverage. ND microelectrodes show a reliable performance in neurotransmitter detection with good antifouling properties. To improve sensitivity, we oxygen plasma etched ND films to activate the surface and intentionally add defects and oxygen surface functional groups. For fast-scan cyclic voltammetry detection of dopamine, oxygen plasma-etching increases the sensitivity from 21 nA/μM to 90 nA/μM after treatment. Fouling was tested by repeated injections of serotonin or tyramine, and both ND and plasma oxidized nanodiamond (NDO) microelectrodes maintain their currents better compared to CFMEs and therefore are more antifouling. Furthermore, a biofouling test in brain slices shows that ND microelectrodes barely have any current drop, while the more hydrophilic NDO microelectrodes decrease more, but still not as much as CFMEs. Overall, grownmore »
- Authors:
-
[1]
- Univ. of Virginia, Charlottesville, VA (United States)
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1997640
- Grant/Contract Number:
- AC05-00OR22725; R01EB026497; R01NS125663
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Sensors
- Additional Journal Information:
- Journal Volume: 7; Journal Issue: 10; Journal ID: ISSN 2379-3694
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; nanodiamond; FSCV; carbon nanomaterials; neurotransmitter detection; electrochemistry
Citation Formats
Shao, Zijun, Wilson, Leslie, Chang, Yuanyu, and Venton, B. Jill. MPCVD-Grown Nanodiamond Microelectrodes with Oxygen Plasma Activation for Neurochemical Applications. United States: N. p., 2022.
Web. doi:10.1021/acssensors.2c01803.
Shao, Zijun, Wilson, Leslie, Chang, Yuanyu, & Venton, B. Jill. MPCVD-Grown Nanodiamond Microelectrodes with Oxygen Plasma Activation for Neurochemical Applications. United States. https://doi.org/10.1021/acssensors.2c01803
Shao, Zijun, Wilson, Leslie, Chang, Yuanyu, and Venton, B. Jill. Wed .
"MPCVD-Grown Nanodiamond Microelectrodes with Oxygen Plasma Activation for Neurochemical Applications". United States. https://doi.org/10.1021/acssensors.2c01803. https://www.osti.gov/servlets/purl/1997640.
@article{osti_1997640,
title = {MPCVD-Grown Nanodiamond Microelectrodes with Oxygen Plasma Activation for Neurochemical Applications},
author = {Shao, Zijun and Wilson, Leslie and Chang, Yuanyu and Venton, B. Jill},
abstractNote = {Nanodiamonds (NDs) are a carbon nanomaterial that has a diamond core with heteroatoms and defects at the surface. The large surface area, defect sites, and functional groups on NDs make them a promising material for electrochemical sensing. Previously, we dip-coated ND onto carbon-fiber microelectrodes (CFMEs) and found increases in sensitivity, but the coating was sparse. Here, for this work, we directly grew thin films of ND on niobium wires using microwave plasma chemical vapor deposition (MP-CVD) to provide full surface coverage. ND microelectrodes show a reliable performance in neurotransmitter detection with good antifouling properties. To improve sensitivity, we oxygen plasma etched ND films to activate the surface and intentionally add defects and oxygen surface functional groups. For fast-scan cyclic voltammetry detection of dopamine, oxygen plasma-etching increases the sensitivity from 21 nA/μM to 90 nA/μM after treatment. Fouling was tested by repeated injections of serotonin or tyramine, and both ND and plasma oxidized nanodiamond (NDO) microelectrodes maintain their currents better compared to CFMEs and therefore are more antifouling. Furthermore, a biofouling test in brain slices shows that ND microelectrodes barely have any current drop, while the more hydrophilic NDO microelectrodes decrease more, but still not as much as CFMEs. Overall, grown ND microelectrodes are promising in neurotransmitter detection with excellent fouling resistance, whereas oxygen plasma etching slightly lowers the fouling resistance but dramatically increases sensitivity.},
doi = {10.1021/acssensors.2c01803},
journal = {ACS Sensors},
number = 10,
volume = 7,
place = {United States},
year = {Wed Oct 12 00:00:00 EDT 2022},
month = {Wed Oct 12 00:00:00 EDT 2022}
}
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Works referenced in this record:
Effect of pH and Surface Functionalities on the Cyclic Voltammetric Responses of Carbon-Fiber Microelectrodes
journal, July 1999
- Runnels, Petrise L.; Joseph, Joshua D.; Logman, Michael J.
- Analytical Chemistry, Vol. 71, Issue 14
X-ray Photoemission Spectroscopy applied to nanodiamonds: From surface chemistry to in situ reactivity
journal, April 2018
- Arnault, J. C.
- Diamond and Related Materials, Vol. 84
Electropolymerized films to prevent interferences and electrode fouling in biosensors
journal, January 1991
- Geise, Robert J.; Adams, John M.; Barone, Neil J.
- Biosensors and Bioelectronics, Vol. 6, Issue 2
A Diamond-Based Electrode for Detection of Neurochemicals in the Human Brain
journal, March 2016
- Bennet, Kevin E.; Tomshine, Jonathan R.; Min, Hoon-Ki
- Frontiers in Human Neuroscience, Vol. 10
Dynamics of Diamond Nanoparticles in Solution and Cells
journal, November 2007
- Neugart, Felix; Zappe, Andrea; Jelezko, Fedor
- Nano Letters, Vol. 7, Issue 12
The CVD of Nanodiamond Materials
journal, July 2008
- Butler, James E.; Sumant, Anirudha V.; Barnard, Amanda S.
- Chemical Vapor Deposition, Vol. 14, Issue 7-8, p. 145-160
Defect Sites Modulate Fouling Resistance on Carbon-Nanotube Fiber Electrodes
journal, March 2019
- Weese, Moriah E.; Krevh, Rachel A.; Li, Yuxin
- ACS Sensors, Vol. 4, Issue 4
Fundamentals of fast-scan cyclic voltammetry for dopamine detection
journal, January 2020
- Venton, B. Jill; Cao, Qun
- The Analyst, Vol. 145, Issue 4
On the history of the discovery of nanodiamond synthesis
journal, April 2004
- Danilenko, V. V.
- Physics of the Solid State, Vol. 46, Issue 4
Nanocrystalline Diamond Electrodes: Enabling electrochemical microsensing applications with high reliability and stability
journal, September 2016
- Siddiqui, Shabnam; Dutta, Gaurab; Tan, Chao
- IEEE Nanotechnology Magazine, Vol. 10, Issue 3
Review: new insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection
journal, January 2019
- Cao, Qun; Puthongkham, Pumidech; Venton, B. Jill
- Analytical Methods, Vol. 11, Issue 3
Nanographene and Nanodiamond; New Members in the Nanocarbon Family
journal, May 2009
- Enoki, Toshiaki; Takai, Kazuyuki; Osipov, Vladimir
- Chemistry – An Asian Journal, Vol. 4, Issue 6
Subsecond Adsorption and Desorption of Dopamine at Carbon-Fiber Microelectrodes
journal, December 2000
- Bath, Bradley D.; Michael, Darren J.; Trafton, B. Jill
- Analytical Chemistry, Vol. 72, Issue 24
Modified Screen-Printed Electrodes Based on Oxidized Graphene Nanoribbons for the Selective Electrochemical Detection of Several Molecules
journal, January 2012
- Valentini, F.; Romanazzo, D.; Carbone, M.
- Electroanalysis, Vol. 24, Issue 4
3D-Printed Carbon Nanoelectrodes for In Vivo Neurotransmitter Sensing
journal, August 2020
- Cao, Qun; Shin, Mimi; Lavrik, Nickolay V.
- Nano Letters, Vol. 20, Issue 9
Biocompatible PEDOT:Nafion Composite Electrode Coatings for Selective Detection of Neurotransmitters in Vivo
journal, February 2015
- Vreeland, Richard F.; Atcherley, Christopher W.; Russell, Wilfred S.
- Analytical Chemistry, Vol. 87, Issue 5
Singular Sheet Etching of Graphene with Oxygen Plasma
journal, March 2014
- Al-Mumen, Haider; Rao, Fubo; Li, Wen
- Nano-Micro Letters, Vol. 6, Issue 2
In Vivo Ambient Serotonin Measurements at Carbon-Fiber Microelectrodes
journal, August 2017
- Abdalla, Aya; Atcherley, Christopher W.; Pathirathna, Pavithra
- Analytical Chemistry, Vol. 89, Issue 18
Boron-doped ultrananocrystalline diamond synthesized with an H-rich/Ar-lean gas system
journal, April 2015
- Zeng, Hongjun; Konicek, Andrew R.; Moldovan, Nicolaie
- Carbon, Vol. 84
Adsorption of Drugs on Nanodiamond: Toward Development of a Drug Delivery Platform
journal, August 2013
- Mochalin, Vadym N.; Pentecost, Amanda; Li, Xue-Mei
- Molecular Pharmaceutics, Vol. 10, Issue 10
An information theory model of hydrophobic interactions.
journal, August 1996
- Hummer, G.; Garde, S.; Garcia, A. E.
- Proceedings of the National Academy of Sciences, Vol. 93, Issue 17
Electrochemical treatment in KOH renews and activates carbon fiber microelectrode surfaces
journal, July 2021
- Cao, Qun; Lucktong, Julia; Shao, Zijun
- Analytical and Bioanalytical Chemistry, Vol. 413, Issue 27
Characterization of Electrode Fouling and Surface Regeneration for a Platinum Electrode on an Electrophoresis Microchip
journal, September 2003
- Manica, Drew P.; Mitsumori, Yutaro; Ewing, Andrew G.
- Analytical Chemistry, Vol. 75, Issue 17
Optimization of the Synthesis of Superhydrophobic Carbon Nanomaterials by Chemical Vapor Deposition
journal, February 2018
- Aljumaily, Mustafa Mohammed; Alsaadi, Mohammed Abdulhakim; Das, Rasel
- Scientific Reports, Vol. 8, Issue 1
Improvement of Voltammetric Detection of Sulfanilamide with a Nanodiamond-Modified Glassy Carbon Electrode
journal, August 2019
- Li, Hao; Kuang, Xinmou; Shen, Xiaolan
- International Journal of Electrochemical Science, Vol. 14, Issue 8
Nanoscale Electrochemistry of sp 2 Carbon Materials: From Graphite and Graphene to Carbon Nanotubes
journal, August 2016
- Unwin, Patrick R.; Güell, Aleix G.; Zhang, Guohui
- Accounts of Chemical Research, Vol. 49, Issue 9
Raman spectroscopy of amorphous, nanostructured, diamond–like carbon, and nanodiamond
journal, September 2004
- Ferrari, Andrea Carlo; Robertson, John
- Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences, Vol. 362, Issue 1824
The effect of electrode size and surface heterogeneity on electrochemical properties of ultrananocrystalline diamond microelectrode
journal, November 2015
- Dutta, Gaurab; Siddiqui, Shabnam; Zeng, Hongjun
- Journal of Electroanalytical Chemistry, Vol. 756
Paper-Based Polymer Electrodes for Bioanalysis and Electrochemistry of Neurotransmitters
journal, January 2018
- Trouillon, Raphaël; Gijs, Martin A. M.
- ChemPhysChem, Vol. 19, Issue 10
Effect of oxygen plasma etching on graphene studied using Raman spectroscopy and electronic transport measurements
journal, February 2011
- Childres, Isaac; Jauregui, Luis A.; Tian, Jifa
- New Journal of Physics, Vol. 13, Issue 2
Nanodiamond Coating Improves the Sensitivity and Antifouling Properties of Carbon Fiber Microelectrodes
journal, August 2019
- Puthongkham, Pumidech; Venton, B. Jill
- ACS Sensors, Vol. 4, Issue 9
Recent strategies to minimise fouling in electrochemical detection systems
journal, April 2016
- Hanssen, Benjamin L.; Siraj, Shajahan; Wong, Danny K. Y.
- Reviews in Analytical Chemistry, Vol. 35, Issue 1
Graphene-Fiber Microelectrodes for Ultrasensitive Neurochemical Detection
journal, March 2022
- Li, Yuxin; Jarosova, Romana; Weese-Myers, Moriah E.
- Analytical Chemistry, Vol. 94, Issue 11
Characterization and Electrochemical Responsiveness of Boron-Doped Nanocrystalline Diamond Thin-Film Electrodes
journal, February 2003
- Show, Yoshiyuki; Witek, Małgorzata A.; Sonthalia, Prerna
- Chemistry of Materials, Vol. 15, Issue 4
Modular theory for DC-biased electrochemical impedance response of supercapacitor
journal, October 2020
- Mishra, Gaurav Kumar; Kant, Rama
- Journal of Power Sources, Vol. 473
Characterization of ultrananocrystalline diamond microsensors for in vivo dopamine detection
journal, June 2013
- Arumugam, Prabhu U.; Zeng, Hongjun; Siddiqui, Shabnam
- Applied Physics Letters, Vol. 102, Issue 25
Resistance to Surfactant and Protein Fouling Effects at Conducting Diamond Electrodes
journal, November 2004
- Shin, Dongchan; Tryk, Donald A.; Fujishima, Akira
- Electroanalysis, Vol. 17, Issue 4
In Vivo Monitoring of Oxygen in Rat Brain by Carbon Fiber Microelectrode Modified with Antifouling Nanoporous Membrane
journal, January 2019
- Zhou, Lin; Hou, Hanfeng; Wei, Huan
- Analytical Chemistry, Vol. 91, Issue 5
Nanodiamond Particles: Properties and Perspectives for Bioapplications
journal, April 2009
- Schrand, Amanda M.; Hens, Suzanne A. Ciftan; Shenderova, Olga A.
- Critical Reviews in Solid State and Materials Sciences, Vol. 34, Issue 1-2
Ultra-small carbon fiber electrode recording site optimization and improved in vivo chronic recording yield
journal, April 2020
- Welle, Elissa J.; Patel, Paras R.; Woods, Joshua E.
- Journal of Neural Engineering, Vol. 17, Issue 2
New prospects and frontiers of nanodiamond clusters
journal, October 2007
- Baidakova, Marina; Vul', Alexander
- Journal of Physics D: Applied Physics, Vol. 40, Issue 20
Carbon Microelectrodes with a Renewable Surface
journal, March 2010
- Takmakov, Pavel; Zachek, Matthew K.; Keithley, Richard B.
- Analytical Chemistry, Vol. 82, Issue 5
All-Diamond Microfiber Electrodes for Neurochemical Analysis
journal, January 2018
- Rusinek, Cory A.; Guo, Yue; Rechenberg, Robert
- Journal of The Electrochemical Society, Vol. 165, Issue 12
Principles of voltammetry and microelectrode surface states
journal, July 1993
- Kawagoe, Kirk T.; Zimmerman, Jayne B.; Wightman, R. Mark
- Journal of Neuroscience Methods, Vol. 48, Issue 3
Enabling long term monitoring of dopamine using dimensionally stable ultrananocrystalline diamond microelectrodes
journal, September 2016
- Dutta, Gaurab; Tan, Chao; Siddiqui, Shabnam
- Materials Research Express, Vol. 3, Issue 9
Specific Oxygen-Containing Functional Groups on the Carbon Surface Underlie an Enhanced Sensitivity to Dopamine at Electrochemically Pretreated Carbon Fiber Microelectrodes
journal, June 2010
- Roberts, James G.; Moody, Benjamin P.; McCarty, Gregory S.
- Langmuir, Vol. 26, Issue 11
Improving serotonin fast-scan cyclic voltammetry detection: new waveforms to reduce electrode fouling
journal, January 2020
- Dunham, Kelly E.; Venton, B. Jill
- The Analyst, Vol. 145, Issue 22
A critical review of nanodiamond based nanocomposites: Synthesis, properties and applications
journal, June 2018
- Zhang, Yinhang; Rhee, Kyong Yop; Hui, David
- Composites Part B: Engineering, Vol. 143
Contribution of Functional Groups to the Raman Spectrum of Nanodiamond Powders
journal, January 2009
- Mochalin, Vadym; Osswald, Sebastian; Gogotsi, Yury
- Chemistry of Materials, Vol. 21, Issue 2
O 2 Plasma Etching and Antistatic Gun Surface Modifications for CNT Yarn Microelectrode Improve Sensitivity and Antifouling Properties
journal, April 2017
- Yang, Cheng; Wang, Ying; Jacobs, Christopher B.
- Analytical Chemistry, Vol. 89, Issue 10
Detecting Subsecond Dopamine Release with Fast-Scan Cyclic Voltammetry in Vivo
journal, October 2003
- Robinson, D. L.
- Clinical Chemistry, Vol. 49, Issue 10
Low-Fouling Nanoporous Conductive Polymer-Coated Microelectrode for In Vivo Monitoring of Dopamine in the Rat Brain
journal, July 2019
- Feng, Taotao; Ji, Wenliang; Tang, Qiao
- Analytical Chemistry, Vol. 91, Issue 16
Control of sp2/sp3 Carbon Ratio and Surface Chemistry of Nanodiamond Powders by Selective Oxidation in Air
journal, September 2006
- Osswald, Sebastian; Yushin, Gleb; Mochalin, Vadym
- Journal of the American Chemical Society, Vol. 128, Issue 35, p. 11635-11642
Nanodiamond: A high impact nanomaterial
journal, February 2017
- Nunn, Nicholas; Torelli, Marco; McGuire, Gary
- Current Opinion in Solid State and Materials Science, Vol. 21, Issue 1
High pressure high temperature synthesis of highly boron doped diamond microparticles and porous electrodes for electrochemical applications
journal, January 2021
- Wood, Georgia F.; Zvoriste-Walters, Carmen E.; Munday, Mark G.
- Carbon, Vol. 171
Advanced Carbon Electrode Materials for Molecular Electrochemistry
journal, July 2008
- McCreery, Richard L.
- Chemical Reviews, Vol. 108, Issue 7, p. 2646-2687
Characterization of Local pH Changes in Brain Using Fast-Scan Cyclic Voltammetry with Carbon Microelectrodes
journal, December 2010
- Takmakov, Pavel; Zachek, Matthew K.; Keithley, Richard B.
- Analytical Chemistry, Vol. 82, Issue 23
Sustained delivery of focal ischemia coupled to real-time neurochemical sensing in brain slices
journal, January 2022
- Cryan, Michael T.; Li, Yuxin; Ross, Ashley E.
- Lab on a Chip, Vol. 22, Issue 11
From Electrode Surface Fouling to Sensitive Electroanalytical Determination of Phenols
journal, May 2013
- Kawde, Abdel-Nasser; Morsy, Mohamed A.; Odewunmi, Nurudeen
- Electroanalysis, Vol. 25, Issue 6
Mechanistic studies of oxygen plasma etching
journal, November 1988
- Hartney, M. A.; Greene, W. M.; Soane, D. S.
- Journal of Vacuum Science & Technology B: Microelectronics Processing and Phenomena, Vol. 6, Issue 6
Increased surface roughness by oxygen plasma treatment of graphite/polymer composite
journal, April 2003
- Cvelbar, U.; Pejovnik, S.; Mozetiè, M.
- Applied Surface Science, Vol. 210, Issue 3-4
Carbon-fiber microelectrodes for in vivo applications
journal, January 2009
- Huffman, Megan L.; Venton, B. Jill
- The Analyst, Vol. 134, Issue 1
Approaching theoretical strength in glassy carbon nanolattices
journal, February 2016
- Bauer, J.; Schroer, A.; Schwaiger, R.
- Nature Materials, Vol. 15, Issue 4
Reactive ion etching of diamond and diamond-like carbon films
journal, April 1994
- Vivensang, C.; Turban, G.; Anger, E.
- Diamond and Related Materials, Vol. 3, Issue 4-6
Thin layer cell behavior of CNT yarn and cavity carbon nanopipette electrodes: Effect on catecholamine detection
journal, November 2020
- Shao, Zijun; Puthongkham, Pumidech; Hu, KeKe
- Electrochimica Acta, Vol. 361
Flexible, diamond-based microelectrodes fabricated using the diamond growth side for neural sensing
journal, July 2020
- Fan, Bin; Rusinek, Cory A.; Thompson, Cort H.
- Microsystems & Nanoengineering, Vol. 6, Issue 1
Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities
journal, January 2021
- Purcell, Erin; Becker, Michael; Guo, Yue
- Micromachines, Vol. 12, Issue 2
Different Electrochemical Behavior of Cationic Dopamine from Anionic Ascorbic Acid and DOPAC at CNT Yarn Microelectrodes
journal, February 2022
- Shao, Zijun; Venton, B. Jill
- Journal of The Electrochemical Society, Vol. 169, Issue 2
The structural and electrochemical properties of boron-doped nanocrystalline diamond thin-film electrodes grown from Ar-rich and H2-rich source gases
journal, April 2009
- Wang, Shihua; Swope, Vernon M.; Butler, James E.
- Diamond and Related Materials, Vol. 18, Issue 4
Fast-Scan Cyclic Voltammetry (FSCV) Detection of Endogenous Octopamine in Drosophila melanogaster Ventral Nerve Cord
journal, July 2016
- Pyakurel, Poojan; Privman Champaloux, Eve; Venton, B. Jill
- ACS Chemical Neuroscience, Vol. 7, Issue 8