Different Electrochemical Behavior of Cationic Dopamine from Anionic Ascorbic Acid and DOPAC at CNT Yarn Microelectrodes

Shao, Zijun; Venton, B. Jill

doi:10.1149/1945-7111/ac4d67

Title: Different Electrochemical Behavior of Cationic Dopamine from Anionic Ascorbic Acid and DOPAC at CNT Yarn Microelectrodes

Journal Article · 31 January 2022 · Journal of the Electrochemical Society

DOI: https://doi.org/10.1149/1945-7111/ac4d67 · OSTI ID:1983009

Shao, Zijun ^[1];

^[1]

University of Virginia, Charlottesville, VA (United States)

Carbon nanotube yarn microelectrodes (CNTYMEs) have micron-scale surface crevices that momentarily trap molecules. CNTYMEs improve selectivity among cationic catecholamines because secondary reactions are enhanced, but no anions have been studied. Here, we compared fast-scan cyclic voltammetry (FSCV) of dopamine and anionic interferents 3,4 dihydroxyphenylacetic acid (DOPAC) and L-ascorbic acid (AA) at CNTYMEs and carbon fiber microelectrodes (CFMEs). At CFMEs, dopamine current decreases with increasing FSCV repetition frequency at pH 7.4, whereas DOPAC and AA have increasing currents with increasing frequency, because of less repulsion at the negative holding potential. Both DOPAC and AA have side reactions after being oxidized, which are enhanced by trapping. At pH 4, the current increases for DOPAC and AA because they are not repelled. In addition, AA has a different oxidation pathway at pH 4, and an extra peak in the CV is enhanced by trapping effects at CNTYMEs. At pH 8.5, co-detection of dopamine in the presence of DOPAC and AA is enhanced at 100 Hz frequency because of differences in secondary peaks. Thus, the trapping effects at CNTYMEs affects anions differently than cations and secondary peaks can be used to identify dopamine in mixture of AA and DOPAC with FSCV.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Sponsoring Organization:: National Institutes of Health (NIH); Owens Family Foundation; USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1983009

Journal Information:: Journal of the Electrochemical Society, Journal Name: Journal of the Electrochemical Society Journal Issue: 2 Vol. 169; ISSN 0013-4651

Publisher:: IOP PublishingCopyright Statement

Country of Publication:: United States

Language:: English

References (44)

Electrochemical Properties of Different Carbon-Fiber Microelectrodes Using Fast-Scan Cyclic Voltammetry Huffman, Megan L.; Venton, B. Jill Electroanalysis, Vol. 20, Issue 22 https://doi.org/10.1002/elan.200804343	journal	November 2008
Electrochemical detection of neurotransmitters: Toward synapse-based neural interfaces Jeon, Joohee; Hwang, Inseong; Chung, Taek Dong Biomedical Engineering Letters, Vol. 6, Issue 3 https://doi.org/10.1007/s13534-016-0230-6	journal	August 2016
Covalent modification of carbon electrodes for voltammetric differentiation of dopamine and ascorbic acid Downard, Alison J.; Roddick, Alisa D.; Bond, Alan M. Analytica Chimica Acta, Vol. 317, Issue 1-3, p. 303-310 https://doi.org/10.1016/0003-2670(95)00397-5	journal	December 1995
Nafion-coated electrodes with high selectivity for CNS electrochemistry Gerhardt, Greg A.; Oke, Arvin F.; Nagy, Geza Brain Research, Vol. 290, Issue 2 https://doi.org/10.1016/0006-8993(84)90963-6	journal	January 1984
Regional distribution of ascorbate and 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum Basse-Tomusk, Allison; Rebec, George V. Brain Research, Vol. 538, Issue 1 https://doi.org/10.1016/0006-8993(91)90372-3	journal	January 1991
Oxidation of L-ascorbic acid on a gold electrode Rueda, M.; Aldaz, A.; Sanchez-Burgos, F. Electrochimica Acta, Vol. 23, Issue 5 https://doi.org/10.1016/0013-4686(78)87040-6	journal	May 1978
Currents in thin layer electrochemical cells with spherical and conical electrodes Davis, Joe M.; Fan, F. -R. F.; Bard, A. J. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, Vol. 238, Issue 1-2 https://doi.org/10.1016/0022-0728(87)85163-X	journal	December 1987
Simultaneous determination of dopamine, ascorbic acid, and uric acid using carbon ionic liquid electrode Safavi, Afsaneh; Maleki, Norouz; Moradlou, Omran Analytical Biochemistry, Vol. 359, Issue 2 https://doi.org/10.1016/j.ab.2006.09.008	journal	December 2006
Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review Yang, Cheng; Denno, Madelaine E.; Pyakurel, Poojan Analytica Chimica Acta, Vol. 887 https://doi.org/10.1016/j.aca.2015.05.049	journal	August 2015
Evaluation of carbon nanotube fiber microelectrodes for neurotransmitter detection: Correlation of electrochemical performance and surface properties Yang, Cheng; Trikantzopoulos, Elefterios; Jacobs, Christopher B. Analytica Chimica Acta, Vol. 965 https://doi.org/10.1016/j.aca.2017.01.039	journal	May 2017
Tracking tonic dopamine levels in vivo using multiple cyclic square wave voltammetry Oh, Yoonbae; Heien, Michael L.; Park, Cheonho Biosensors and Bioelectronics, Vol. 121 https://doi.org/10.1016/j.bios.2018.08.034	journal	December 2018
Regulation of embryonic neurotransmitter and tyrosine hydroxylase protein levels by ascorbic acid Meredith, M. Elizabeth; May, James M. Brain Research, Vol. 1539 https://doi.org/10.1016/j.brainres.2013.09.040	journal	November 2013
Laccase-catalyzed oxidation and intramolecular cyclization of dopamine: A new method for selective determination of dopamine with laccase/carbon nanotube-based electrochemical biosensors Xiang, Ling; Lin, Yuqing; Yu, Ping Electrochimica Acta, Vol. 52, Issue 12 https://doi.org/10.1016/j.electacta.2006.11.040	journal	March 2007
Electrochemical methods for ascorbic acid determination Pisoschi, Aurelia Magdalena; Pop, Aneta; Serban, Andreea Iren Electrochimica Acta, Vol. 121 https://doi.org/10.1016/j.electacta.2013.12.127	journal	March 2014
Thin layer cell behavior of CNT yarn and cavity carbon nanopipette electrodes: Effect on catecholamine detection Shao, Zijun; Puthongkham, Pumidech; Hu, KeKe Electrochimica Acta, Vol. 361 https://doi.org/10.1016/j.electacta.2020.137032	journal	November 2020
Electrochemical dopamine detection: Comparing gold and carbon fiber microelectrodes using background subtracted fast scan cyclic voltammetry Zachek, Matthew K.; Hermans, Andre; Wightman, R. Mark Journal of Electroanalytical Chemistry, Vol. 614, Issue 1-2 https://doi.org/10.1016/j.jelechem.2007.11.007	journal	March 2008
Mechanistic insights into the electrochemical oxidation of dopamine by cyclic voltammetry Schindler, Sabrina; Bechtold, Thomas Journal of Electroanalytical Chemistry, Vol. 836 https://doi.org/10.1016/j.jelechem.2019.01.069	journal	March 2019
Electrochemical sensors and biosensors for determination of catecholamine neurotransmitters: A review Ribeiro, José A.; Fernandes, Paula M. V.; Pereira, Carlos M. Talanta, Vol. 160 https://doi.org/10.1016/j.talanta.2016.06.066	journal	November 2016
Adsorption of catechols on fractured glassy carbon electrode surfaces Allred, Christie D.; McCreery, Richard L. Analytical Chemistry, Vol. 64, Issue 4 https://doi.org/10.1021/ac00028a020	journal	February 1992
Subsecond Adsorption and Desorption of Dopamine at Carbon-Fiber Microelectrodes Bath, Bradley D.; Michael, Darren J.; Trafton, B. Jill Analytical Chemistry, Vol. 72, Issue 24 https://doi.org/10.1021/ac000849y	journal	December 2000
Fast-scan voltammetry of biogenic amines Baur, John E.; Kristensen, Eric W.; May, Leslie J. Analytical Chemistry, Vol. 60, Issue 13 https://doi.org/10.1021/ac00164a006	journal	July 1988
Heterogeneous mechanisms of the oxidation of catechols and ascorbic acid at carbon electrodes Deakin, Mark R.; Kovach, Paul M.; Stutts, K. J. Analytical Chemistry, Vol. 58, Issue 7 https://doi.org/10.1021/ac00298a046	journal	June 1986
Response Times of Carbon Fiber Microelectrodes to Dynamic Changes in Catecholamine Concentration Venton, B. Jill; Troyer, Kevin P.; Wightman, R. Mark Analytical Chemistry, Vol. 74, Issue 3 https://doi.org/10.1021/ac010819a	journal	February 2002
Psychoanalytical Electrochemistry: Dopamine and Behavior Venton, B. Jill; Wightman, R. Mark Analytical Chemistry, Vol. 75, Issue 19 https://doi.org/10.1021/ac031421c	journal	October 2003
Resolving Neurotransmitters Detected by Fast-Scan Cyclic Voltammetry Heien, Michael L. A. V.; Johnson, Michael A.; Wightman, R. Mark Analytical Chemistry, Vol. 76, Issue 19 https://doi.org/10.1021/ac0491509	journal	October 2004
Biocompatible PEDOT:Nafion Composite Electrode Coatings for Selective Detection of Neurotransmitters in Vivo Vreeland, Richard F.; Atcherley, Christopher W.; Russell, Wilfred S. Analytical Chemistry, Vol. 87, Issue 5 https://doi.org/10.1021/ac502165f	journal	February 2015
O ₂ Plasma Etching and Antistatic Gun Surface Modifications for CNT Yarn Microelectrode Improve Sensitivity and Antifouling Properties Yang, Cheng; Wang, Ying; Jacobs, Christopher B. Analytical Chemistry, Vol. 89, Issue 10 https://doi.org/10.1021/acs.analchem.7b00785	journal	April 2017
Cavity Carbon-Nanopipette Electrodes for Dopamine Detection Yang, Cheng; Hu, Keke; Wang, Dengchao Analytical Chemistry, Vol. 91, Issue 7 https://doi.org/10.1021/acs.analchem.8b05885	journal	February 2019
Mechanism of Histamine Oxidation and Electropolymerization at Carbon Electrodes Puthongkham, Pumidech; Lee, Scott T.; Venton, B. Jill Analytical Chemistry, Vol. 91, Issue 13 https://doi.org/10.1021/acs.analchem.9b01178	journal	June 2019
Multiwalled Carbon Nanotubes/Nanofibrillar Cellulose/Nafion Composite-Modified Tetrahedral Amorphous Carbon Electrodes for Selective Dopamine Detection Durairaj, Vasuki; Wester, Niklas; Etula, Jarkko The Journal of Physical Chemistry C, Vol. 123, Issue 40 https://doi.org/10.1021/acs.jpcc.9b05537	journal	September 2019
Influence of Geometry on Thin Layer and Diffusion Processes at Carbon Electrodes Cao, Qun; Shao, Zijun; Hensley, Dale K. Langmuir, Vol. 37, Issue 8 https://doi.org/10.1021/acs.langmuir.0c03315	journal	February 2021
Laser Treated Carbon Nanotube Yarn Microelectrodes for Rapid and Sensitive Detection of Dopamine in Vivo Yang, Cheng; Trikantzopoulos, Elefterios; Nguyen, Michael D. ACS Sensors, Vol. 1, Issue 5 https://doi.org/10.1021/acssensors.6b00021	journal	March 2016
Anodic oxidation pathways of aromatic hydrocarbons and amines Adams, Ralph Norman Accounts of Chemical Research, Vol. 2, Issue 6 https://doi.org/10.1021/ar50018a003	journal	June 1969
Advanced Carbon Electrode Materials for Molecular Electrochemistry McCreery, Richard L. Chemical Reviews, Vol. 108, Issue 7, p. 2646-2687 https://doi.org/10.1021/cr068076m	journal	July 2008
Carbon Nanotube Yarn Electrodes for Enhanced Detection of Neurotransmitter Dynamics in Live Brain Tissue Schmidt, Andreas C.; Wang, Xin; Zhu, Yuntian ACS Nano, Vol. 7, Issue 9 https://doi.org/10.1021/nn402857u	journal	August 2013
Carbon-fiber microelectrodes for in vivo applications Huffman, Megan L.; Venton, B. Jill The Analyst, Vol. 134, Issue 1 https://doi.org/10.1039/B807563H	journal	January 2009
Fundamentals of fast-scan cyclic voltammetry for dopamine detection Venton, B. Jill; Cao, Qun The Analyst, Vol. 145, Issue 4 https://doi.org/10.1039/C9AN01586H	journal	January 2020
Dopamine oxidation at gold electrodes: mechanism and kinetics near neutral pH Bacil, Raphael P.; Chen, Lifu; Serrano, Silvia H. P. Physical Chemistry Chemical Physics, Vol. 22, Issue 2 https://doi.org/10.1039/C9CP05527D	journal	January 2020
Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward Kishida, Kenneth T.; Saez, Ignacio; Lohrenz, Terry Proceedings of the National Academy of Sciences, Vol. 113, Issue 1 https://doi.org/10.1073/pnas.1513619112	journal	November 2015
High performance, low cost carbon nanotube yarn based 3D printed electrodes compatible with a conventional screen printed electrode system Yang, Cheng; Venton, B. Jill 2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) https://doi.org/10.1109/MeMeA.2017.7985857	conference	May 2017
Mechanism of L-ascorbic acid oxidation and dehydro-L-ascorbic acid reduction on a mercury electrode. I. Acid medium Ruiz, Juan José; Aldaz, Antonio; Dominguez, Manuel Canadian Journal of Chemistry, Vol. 55, Issue 15 https://doi.org/10.1139/v77-389	journal	August 1977
Mechanism of L-ascorbic acid oxidation on a mercury electrode. II. Basic medium Ruiz, Juan José; Aldaz, Antonio; Dominguez, Manuel Canadian Journal of Chemistry, Vol. 56, Issue 11 https://doi.org/10.1139/v78-248	journal	June 1978
Spinning yarn from long carbon nanotube arrays Jayasinghe, Chaminda; Chakrabarti, Supriya; Schulz, Mark J. Journal of Materials Research, Vol. 26, Issue 5 https://doi.org/10.1557/jmr.2010.91	journal	February 2011
Spinning Carbon Nanotube Nanothread under a Scanning Electron Microscope Li, Weifeng; Jayasinghe, Chaminda; Shanov, Vesselin Materials, Vol. 4, Issue 9 https://doi.org/10.3390/ma4091519	journal	August 2011

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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Title: Different Electrochemical Behavior of Cationic Dopamine from Anionic Ascorbic Acid and DOPAC at CNT Yarn Microelectrodes

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