This content will become publicly available on Sun Jul 28 00:00:00 EDT 2024
Carbon nanospikes have improved sensitivity and antifouling properties for adenosine, hydrogen peroxide, and histamine
Abstract
Carbon nanospikes (CNSs) are a new nanomaterial that has enhanced surface roughness and surface oxide concentration, increasing the sensitivity for dopamine detection. However, CNS-modified electrodes (CNSMEs) have not been characterized for other neurochemicals, particularly those with higher oxidation potentials. The purpose of this study was to evaluate CNSMEs for the detection of adenosine, hydrogen peroxide (H2O2), and histamine. The sensitivity increased with CNSs, and signals at CNSMEs were about 3.3 times higher than CFMEs. Normalizing for surface area differences using background currents, CNSMEs show an increased signal of 4.8 times for adenosine, 1.5 times for H2O2, and 2 times for histamine. CNSMEs promoted the formation of secondary products for adenosine and histamine, which enables differentiation from other analytes with similar oxidation potentials. Furthermore, CNSs also selectively enhance the sensitivity for adenosine and histamine compared to H2O2. A scan rate test reveals that adenosine is more adsorption-controlled at CNS electrodes than CFMEs. CNSMEs are antifouling for histamine, with less fouling because the polymers formed after histamine electrooxidation do not adsorb due to an elevated number of edge planes. CNSMEs were useful for detecting each analyte applied in brain slices. Because of the hydrophilic surface compared to CFMEs, CNSMEs also have reducedmore »
- Authors:
-
[2];
[1]
- Univ. of Virginia, Charlottesville, VA (United States)
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF); National Institutes of Health (NIH)
- OSTI Identifier:
- 1994675
- Grant/Contract Number:
- AC05-00OR22725; R01MH085159; R01NS125663
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Analytical and Bioanalytical Chemistry
- Additional Journal Information:
- Journal Volume: 1; Journal Issue: 1; Journal ID: ISSN 1618-2642
- Publisher:
- Springer
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; carbon nanospikes; defect sites; adsorption; electrostatic force; antifouling; biofouling
Citation Formats
Zhao, He, Shrestha, Kailash, Hensley, Dale K., and Venton, B. Jill. Carbon nanospikes have improved sensitivity and antifouling properties for adenosine, hydrogen peroxide, and histamine. United States: N. p., 2023.
Web. doi:10.1007/s00216-023-04875-5.
Zhao, He, Shrestha, Kailash, Hensley, Dale K., & Venton, B. Jill. Carbon nanospikes have improved sensitivity and antifouling properties for adenosine, hydrogen peroxide, and histamine. United States. https://doi.org/10.1007/s00216-023-04875-5
Zhao, He, Shrestha, Kailash, Hensley, Dale K., and Venton, B. Jill. Fri .
"Carbon nanospikes have improved sensitivity and antifouling properties for adenosine, hydrogen peroxide, and histamine". United States. https://doi.org/10.1007/s00216-023-04875-5.
@article{osti_1994675,
title = {Carbon nanospikes have improved sensitivity and antifouling properties for adenosine, hydrogen peroxide, and histamine},
author = {Zhao, He and Shrestha, Kailash and Hensley, Dale K. and Venton, B. Jill},
abstractNote = {Carbon nanospikes (CNSs) are a new nanomaterial that has enhanced surface roughness and surface oxide concentration, increasing the sensitivity for dopamine detection. However, CNS-modified electrodes (CNSMEs) have not been characterized for other neurochemicals, particularly those with higher oxidation potentials. The purpose of this study was to evaluate CNSMEs for the detection of adenosine, hydrogen peroxide (H2O2), and histamine. The sensitivity increased with CNSs, and signals at CNSMEs were about 3.3 times higher than CFMEs. Normalizing for surface area differences using background currents, CNSMEs show an increased signal of 4.8 times for adenosine, 1.5 times for H2O2, and 2 times for histamine. CNSMEs promoted the formation of secondary products for adenosine and histamine, which enables differentiation from other analytes with similar oxidation potentials. Furthermore, CNSs also selectively enhance the sensitivity for adenosine and histamine compared to H2O2. A scan rate test reveals that adenosine is more adsorption-controlled at CNS electrodes than CFMEs. CNSMEs are antifouling for histamine, with less fouling because the polymers formed after histamine electrooxidation do not adsorb due to an elevated number of edge planes. CNSMEs were useful for detecting each analyte applied in brain slices. Because of the hydrophilic surface compared to CFMEs, CNSMEs also have reduced biofouling when used in tissue. Therefore, CNSMEs are useful for tissue measurements of adenosine, hydrogen peroxide, and histamine with high selectivity and low fouling.},
doi = {10.1007/s00216-023-04875-5},
journal = {Analytical and Bioanalytical Chemistry},
number = 1,
volume = 1,
place = {United States},
year = {Fri Jul 28 00:00:00 EDT 2023},
month = {Fri Jul 28 00:00:00 EDT 2023}
}
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