Mass spectrometric immunoassay

Nelson, Randall W; Williams, Peter; Krone, Jennifer Reeve

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Title: Mass spectrometric immunoassay

Abstract

Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

Inventors:

Nelson, Randall W ^[1]; Williams, Peter ^[1]; Krone, Jennifer Reeve ^[2]

Phoenix, AZ
Granbury, TX

Issue Date:: 2007-12-04

Research Org.:: Arizona State Univ., Tempe, AZ (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 920671

Patent Number(s):: 7303888

Application Number:: 11/459,471

Assignee:: Intrinsic Bioprobes, Inc. (Tempe, AZ)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/6816 - characterised by the detection means
C12Q1/6872 - involving mass spectrometry

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N24/00 - Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
G01N33/5302 - {Apparatus specially adapted for immunological test procedures}
G01N33/54373 - {involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings}
G01N33/6851 - {Methods of protein analysis involving laser desorption ionisation mass spectrometry}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/24 - Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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DOE Contract Number:: FG02-91ER61127

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Citation Formats


                    Nelson, Randall W, Williams, Peter, and Krone, Jennifer Reeve. Mass spectrometric immunoassay.  United States: N. p., 2007. 
        Web.

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                    Nelson, Randall W, Williams, Peter, & Krone, Jennifer Reeve. Mass spectrometric immunoassay.  United States.

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                    Nelson, Randall W, Williams, Peter, and Krone, Jennifer Reeve. Tue .  
        "Mass spectrometric immunoassay".  United States.  https://www.osti.gov/servlets/purl/920671.

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@article{osti_920671,

  title        = {Mass spectrometric immunoassay},

  author       = {Nelson, Randall W and Williams, Peter and Krone, Jennifer Reeve},

  abstractNote = {Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2007},

  month        = {12}

}

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Works referenced in this record:

Quantitative analysis of low molecular weight compounds of biological interest by matrix-assisted laser desorption ionization
journal, December 1993

Duncan, Mark W.; Matanovic, Gabrijela; Cerpa-Poljak, Anne
Rapid Communications in Mass Spectrometry, Vol. 7, Issue 12
https://doi.org/10.1002/rcm.1290071207

Direct Analysis of Affinity-Bound Analytes by MALDI/TOF MS
journal, September 1994

Papac, Damon I.; Hoyes, John.; Tomer, Kenneth B.
Analytical Chemistry, Vol. 66, Issue 17
https://doi.org/10.1021/ac00089a004

Quantitative profiling of 6-ketoprostaglandin F1α, 2,3-dinor-6-ketoprostaglandin F1α, thromboxane B2 and 2,3-dinor-thromboxane B2 in human and rat urine by immunoaffinity extraction with gas chromatography—mass spectrometry
journal, January 1989

Chiabrando, Chiara; Pinciroli, Vittorio; Campoleoni, Andrea
Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 495
https://doi.org/10.1016/S0378-4347(00)82604-3

Immunoadsorption to improve gas chromatography/high-resolution mass spectrometry of estradiol-17 beta in plasma.
journal, April 1983

Gaskell, S. J.; Brownsey, B. G.
Clinical Chemistry, Vol. 29, Issue 4
https://doi.org/10.1093/clinchem/29.4.677

Quantification of steroid conjugates using fast atom bombardment mass spectrometry
journal, October 1990

Gaskell, Simon J.
Steroids, Vol. 55, Issue 10
https://doi.org/10.1016/0039-128X(90)90014-3