Mass spectrometric immunoassay

Nelson, Randall W; Williams, Peter; Krone, Jennifer Reeve

Title: Mass spectrometric immunoassay

Patent · Tue Jul 16 00:00:00 EDT 2013

OSTI ID:1087876

Nelson, Randall W; Williams, Peter; Krone, Jennifer Reeve

Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

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Research Organization:: Intrinsic Bioprobes, Inc. (Tempe, AZ)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-91ER61127

Assignee:: Intrinsic Bioprobes, Inc. (Tempe, AZ)

Patent Number(s):: 8,486,713

Application Number:: 13/421,633

OSTI ID:: 1087876

Country of Publication:: United States

Language:: English

References (20)

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Mass spectrometric immunoassay Nelson, Randall W.; Williams, Peter; Krone, Jennifer Reeve https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6974704 US Patent Document 6,974,704	patent	December 2005
Device and method for affinity separation Raybuck, Margaret P.; Kenrick, Michael Kenneth; Parry, David A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5833927 US Patent Document 5,833,927	patent	November 1998
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Mass spectrometric immunoassay Nelson, Randall W.; Williams, Peter; Krone, Jennifer Reeve https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7303888 US Patent Document 7,303,888	patent	December 2007
Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases Yates, John; Eng, James K. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5538897 US Patent Document 5,538,897	patent	July 1996
Mass spectrometric immunoassay analysis of specific proteins and variants present in various biological fluids Nelson, Randall W.; Williams, Peter; Krone, Jennifer Reeve https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7396687 US Patent Document 7,396,687	patent	July 2008
Quantitative analysis of low molecular weight compounds of biological interest by matrix-assisted laser desorption ionization Duncan, Mark W.; Matanovic, Gabrijela; Cerpa-Poljak, Anne Rapid Communications in Mass Spectrometry, Vol. 7, Issue 12 https://doi.org/10.1002/rcm.1290071207	journal	December 1993
Quantitative profiling of 6-ketoprostaglandin F1α, 2,3-dinor-6-ketoprostaglandin F1α, thromboxane B2 and 2,3-dinor-thromboxane B2 in human and rat urine by immunoaffinity extraction with gas chromatography—mass spectrometry Chiabrando, Chiara; Pinciroli, Vittorio; Campoleoni, Andrea Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 495 https://doi.org/10.1016/S0378-4347(00)82604-3	journal	January 1989
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Solid phase system for sequential reactions Rampal, Jang B.; Harbaugh, Jon F. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5437979 US Patent Document 5,437,979	patent	August 1995
Surface-enhanced neat desorption for disorption and detection of analytes Hutchens, T. William; Yip, Tai-Tung https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5894063 US Patent Document 5,894,063	patent	April 1999

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