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Title: Mass spectrometric immunoassay

Abstract

Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

Inventors:
; ;
Issue Date:
Research Org.:
Intrinsic Bioprobes, Inc., Tempe, AZ (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175578
Patent Number(s):
6974704
Application Number:
09/808,275
Assignee:
Intrinsic Bioprobes, Inc. (Tempe, AZ)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
FG02-91ER61127
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Nelson, Randall W., Williams, Peter, and Krone, Jennifer Reeve. Mass spectrometric immunoassay. United States: N. p., 2005. Web.
Nelson, Randall W., Williams, Peter, & Krone, Jennifer Reeve. Mass spectrometric immunoassay. United States.
Nelson, Randall W., Williams, Peter, and Krone, Jennifer Reeve. Tue . "Mass spectrometric immunoassay". United States. https://www.osti.gov/servlets/purl/1175578.
@article{osti_1175578,
title = {Mass spectrometric immunoassay},
author = {Nelson, Randall W. and Williams, Peter and Krone, Jennifer Reeve},
abstractNote = {Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {12}
}

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Works referenced in this record:

Direct Analysis of Affinity-Bound Analytes by MALDI/TOF MS
journal, September 1994


Immunoaffinity Extraction of 4-Hydroxy-2-(4-methylphenyl)benzothiazole and Its Metabolites for Determination by Gas Chromatography-Mass Spectrometry.
journal, January 1994


Mass Spectrometric Immunoassay
journal, April 1995