Mass spectrometric immunoassay
Abstract
Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.
- Inventors:
- Issue Date:
- Research Org.:
- Intrinsic Bioprobes, Inc., Tempe, AZ (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175578
- Patent Number(s):
- 6974704
- Application Number:
- 09/808,275
- Assignee:
- Intrinsic Bioprobes, Inc. (Tempe, AZ)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- FG02-91ER61127
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Nelson, Randall W., Williams, Peter, and Krone, Jennifer Reeve. Mass spectrometric immunoassay. United States: N. p., 2005.
Web.
Nelson, Randall W., Williams, Peter, & Krone, Jennifer Reeve. Mass spectrometric immunoassay. United States.
Nelson, Randall W., Williams, Peter, and Krone, Jennifer Reeve. Tue .
"Mass spectrometric immunoassay". United States. https://www.osti.gov/servlets/purl/1175578.
@article{osti_1175578,
title = {Mass spectrometric immunoassay},
author = {Nelson, Randall W. and Williams, Peter and Krone, Jennifer Reeve},
abstractNote = {Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {12}
}
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