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Title: Focused analyte spray emission apparatus and process for mass spectrometric analysis

Abstract

An apparatus and process are disclosed that deliver an analyte deposited on a substrate to a mass spectrometer that provides for trace analysis of complex organic analytes. Analytes are probed using a small droplet of solvent that is formed at the junction between two capillaries. A supply capillary maintains the droplet of solvent on the substrate; a collection capillary collects analyte desorbed from the surface and emits analyte ions as a focused spray to the inlet of a mass spectrometer for analysis. The invention enables efficient separation of desorption and ionization events, providing enhanced control over transport and ionization of the analyte.

Inventors:
 [1];  [2];  [2]
  1. Kennewick, WA
  2. Richland, WA
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1034908
Patent Number(s):
8097845
Application Number:
12/722,257
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Roach, Patrick J, Laskin, Julia, and Laskin, Alexander. Focused analyte spray emission apparatus and process for mass spectrometric analysis. United States: N. p., 2012. Web.
Roach, Patrick J, Laskin, Julia, & Laskin, Alexander. Focused analyte spray emission apparatus and process for mass spectrometric analysis. United States.
Roach, Patrick J, Laskin, Julia, and Laskin, Alexander. Tue . "Focused analyte spray emission apparatus and process for mass spectrometric analysis". United States. https://www.osti.gov/servlets/purl/1034908.
@article{osti_1034908,
title = {Focused analyte spray emission apparatus and process for mass spectrometric analysis},
author = {Roach, Patrick J and Laskin, Julia and Laskin, Alexander},
abstractNote = {An apparatus and process are disclosed that deliver an analyte deposited on a substrate to a mass spectrometer that provides for trace analysis of complex organic analytes. Analytes are probed using a small droplet of solvent that is formed at the junction between two capillaries. A supply capillary maintains the droplet of solvent on the substrate; a collection capillary collects analyte desorbed from the surface and emits analyte ions as a focused spray to the inlet of a mass spectrometer for analysis. The invention enables efficient separation of desorption and ionization events, providing enhanced control over transport and ionization of the analyte.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {1}
}

Works referenced in this record:

Molecular Characterization of Organic Aerosols Using Nanospray-Desorption/Electrospray Ionization-Mass Spectrometry
journal, October 2010