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Title: Gastrin Receptor-Avid Peptide Conjugates

Abstract

A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

Inventors:
 [1];  [1];  [2];  [3];  [1]
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  1. Columbia, MO
  2. Baltimore, MD
  3. Ashland, MO
Issue Date:
Research Org.:
Univ. of Missouri, Columbia, MO (United States)
OSTI Identifier:
879767
Patent Number(s):
6921526
Application Number:
10/122611
Assignee:
Curators of the University of Missouri (Columbia, MO)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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DOE Contract Number:  
FG02-89ER60875
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Hoffman, Timothy J, Volkert, Wynn A, Li, Ning, Sieckman, Gary, and Higginbotham, Chrys-Ann. Gastrin Receptor-Avid Peptide Conjugates. United States: N. p., 2005. Web.
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Hoffman, Timothy J, Volkert, Wynn A, Li, Ning, Sieckman, Gary, & Higginbotham, Chrys-Ann. Gastrin Receptor-Avid Peptide Conjugates. United States.
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Hoffman, Timothy J, Volkert, Wynn A, Li, Ning, Sieckman, Gary, and Higginbotham, Chrys-Ann. Tue . "Gastrin Receptor-Avid Peptide Conjugates". United States. https://www.osti.gov/servlets/purl/879767.
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@article{osti_879767,
title = {Gastrin Receptor-Avid Peptide Conjugates},
author = {Hoffman, Timothy J and Volkert, Wynn A and Li, Ning and Sieckman, Gary and Higginbotham, Chrys-Ann},
abstractNote = {A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 26 00:00:00 EDT 2005},
month = {Tue Jul 26 00:00:00 EDT 2005}
}
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Works referenced in this record:

Design and characterization of  -melanotropin peptide analogs cyclized through rhenium and technetium metal coordination
journal, October 1998

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