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Title: Gastrin receptor-avid peptide conjugates

Abstract

A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Univ. of Missouri, Columbia, MO (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176023
Patent Number(s):
7147838
Application Number:
11/025,636
Assignee:
Curators of the University Of Missouri
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
DOE Contract Number:  
FG02-89ER60875
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Hoffman, Timothy J., Volkert, Wynn A., Li, Ning, Sieckman, Gary, and Higginbotham, Chrys-Ann. Gastrin receptor-avid peptide conjugates. United States: N. p., 2006. Web.
Hoffman, Timothy J., Volkert, Wynn A., Li, Ning, Sieckman, Gary, & Higginbotham, Chrys-Ann. Gastrin receptor-avid peptide conjugates. United States.
Hoffman, Timothy J., Volkert, Wynn A., Li, Ning, Sieckman, Gary, and Higginbotham, Chrys-Ann. Tue . "Gastrin receptor-avid peptide conjugates". United States. https://www.osti.gov/servlets/purl/1176023.
@article{osti_1176023,
title = {Gastrin receptor-avid peptide conjugates},
author = {Hoffman, Timothy J. and Volkert, Wynn A. and Li, Ning and Sieckman, Gary and Higginbotham, Chrys-Ann},
abstractNote = {A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {12}
}