Gastrin receptor-avid peptide conjugates
Abstract
A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a-moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Missouri, Columbia, MO (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175787
- Patent Number(s):
- 7060247
- Application Number:
- 09/847,134
- Assignee:
- University Of Missouri
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- FG02-89ER60875
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Hoffman, Timothy J., Volkert, Wynn A., Sieckman, Gary, Smith, Charles J., and Gali, Hariprasad. Gastrin receptor-avid peptide conjugates. United States: N. p., 2006.
Web.
Hoffman, Timothy J., Volkert, Wynn A., Sieckman, Gary, Smith, Charles J., & Gali, Hariprasad. Gastrin receptor-avid peptide conjugates. United States.
Hoffman, Timothy J., Volkert, Wynn A., Sieckman, Gary, Smith, Charles J., and Gali, Hariprasad. Tue .
"Gastrin receptor-avid peptide conjugates". United States. https://www.osti.gov/servlets/purl/1175787.
@article{osti_1175787,
title = {Gastrin receptor-avid peptide conjugates},
author = {Hoffman, Timothy J. and Volkert, Wynn A. and Sieckman, Gary and Smith, Charles J. and Gali, Hariprasad},
abstractNote = {A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a-moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {6}
}
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Works referenced in this record:
The Design of Site-Directed Radiopharmaceuticals for Use in Drug Discovery
book, January 1993
- Eckelman, William C.; Gibson, Raymond E.
- Nuclear Imaging in Drug Discovery, Development, and Approval
Potent Gastrin-Releasing Peptide (GRP) Antagonists Derived from GRP(19-27) with a C-Terminal DPro.PSI.[CH2NH]Phe-NH2 and N-Terminal Aromatic Residues
journal, February 1994
- Leban, Johann J.; Landavazo, Antonio; McDermed, John D.
- Journal of Medicinal Chemistry, Vol. 37, Issue 4
BW2258U89: A GRP receptor antagonist which inhibits small cell lung cancer growth
journal, January 1995
- Moody, Terry W.; Venugopal, Rajesh; Zia, Farah
- Life Sciences, Vol. 56, Issue 7
Metabolic stability and tumor inhibition of bombesin/GRP receptor antagonists
journal, March 1992
- Davis, T. P.; Crowell, S.; Taylor, J.
- Peptides, Vol. 13, Issue 2
Synthesis, Characterization, and Labeling with 99m Tc/ 188 Re of Peptide Conjugates Containing a Dithia-bisphosphine Chelating Agent
journal, May 2001
- Gali, Hariprasad; Hoffman, Timothy J.; Sieckman, Gary L.
- Bioconjugate Chemistry, Vol. 12, Issue 3
Chemical and physical properties of radionuclides
journal, January 1987
- Troutner, David E.
- International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 14, Issue 3
Yttrium-90 and indium-111 labelling, receptor binding and biodistribution of [DOTA0,d-Phe1,Tyr3]octreotide, a promising somatostatin analogue for radionuclide therapy
journal, April 1997
- de Jong, Marion; Bakker, Willem H.; Krenning, Eric P.
- European Journal of Nuclear Medicine, Vol. 24, Issue 4
Vehicles, Chelators, and Radionuclides: Choosing the “Building Blocks” of an Effective Therapeutic Radioimmunoconjugate
journal, January 1996
- Schubiger, P. August; Alberto, Roger; Smith, Alan
- Bioconjugate Chemistry, Vol. 7, Issue 2
Radiochemical investigations of 177Lu-DOTA-8-Aoc-BBN[7-14]NH2: A new gastrin releasing peptide receptor (GRPr) targeting radiopharma ceutical
journal, May 2001
- Smith, Charles J.; Hoffman, Timothy J.; Hayes, Donald L.
- Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 44, Issue S1
Pseudononapeptide bombesin antagonists containing C-terminal Trp or Tpi
journal, March 1992
- Cai, Ren-Zhi; Radulovic, Sinisa; Pinski, Jacek
- Peptides, Vol. 13, Issue 2
Potent bombesin antagonists with C-terminal Leu-psi(CH2-N)-Tac-NH2 or its derivatives.
journal, December 1994
- Cai, R. Z.; Reile, H.; Armatis, P.
- Proceedings of the National Academy of Sciences, Vol. 91, Issue 26
Bombesin antagonists inhibit in vitro and in vivo growth of human gastric cancer and binding of bombesin to its receptors
journal, September 1994
- Qin, Yunfeng; Halmos, Gabor; Cai, Ren-Zhi
- Journal of Cancer Research and Clinical Oncology, Vol. 120, Issue 9
In vitro and in vivo characterization of novel water-soluble dithio-bisphosphine 99mTc complexes
journal, October 1997
- Smith, C. J.; Li, N.; Katti, K. V.
- Nuclear Medicine and Biology, Vol. 24, Issue 7
The mechanism of receptor-mediated endocytosis
journal, December 1991
- Smythe, Elizabeth; Warren, Graham
- European Journal of Biochemistry, Vol. 202, Issue 3
Radiolabeling with technetium-99m to study high-capacity and low-capacity biochemical systems
journal, March 1995
- Eckelman, William C.
- European Journal of Nuclear Medicine, Vol. 22, Issue 3
Rhenium(V) and Technetium(V) Oxo Complexes of an N 2 N‘S Peptidic Chelator: Evidence of Interconversion between the Syn and Anti Conformations
journal, December 1997
- Wong, Ernest; Fauconnier, Theresa; Bennett, Samantha
- Inorganic Chemistry, Vol. 36, Issue 25
Development of an in vitro model for assessing the in vivo stability of lanthanide chelates
journal, February 2001
- Li, W. P.; Ma, D. S.; Higginbotham, C.
- Nuclear Medicine and Biology, Vol. 28, Issue 2
Comparisons of 105Rh(III) Chloride Complexation with [14]aneNS3, [14]aneN2S2 and [14]aneN4 Macrocycles in Aqueous Solution
journal, January 1996
- Li, Ν.; Eberlein, C. M.; Volkert, W. A.
- Radiochimica Acta, Vol. 75, Issue 2
BW1023U90: A new GRP receptor antagonist for small-cell lung cancer cells
journal, January 1996
- Moody, T. W.; Venugopal, R.; Hu, V.
- Peptides, Vol. 17, Issue 8
Binding, internalization, and processing of bombesin by rat pancreatic acini
journal, July 1991
- Zhu, W. Y.; Goke, B.; Williams, J. A.
- American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 261, Issue 1
No carrier added preparations of ‘3 + 1’ mixed-ligand 99mTc complexes
journal, January 1998
- Seifert, Seep; Pietzsch, Hans-Juergen; Scheunemann, Matthias
- Applied Radiation and Isotopes, Vol. 49, Issue 1-2
Pharmacokinetics of Antibodies and their Radiolabels
book, January 2018
- Mattes, M. J.
- Cancer Therapy with Radiolabeled Antibodies
Tumour targeting with radiolabelled macrocycle–antibody conjugates
journal, January 1990
- Parker, David
- Chem. Soc. Rev., Vol. 19, Issue 3
Characterization of high-affinity receptors for bombesin/gastrin releasing peptide on the human prostate cancer cell lines PC-3 and DU-145: Internalization of receptor bound125I-(Tyr4) bombesin by tumor cells
journal, July 1994
- Reile, Herta; Armatis, Patricia E.; Schally, Andrew V.
- The Prostate, Vol. 25, Issue 1
Design and development of receptor-avid peptide conjugates for in-vivo targeting of cancer
conference, July 1999
- Volkert, Wynn A.; Hoffman, Timothy J.
- BiOS '99 International Biomedical Optics Symposium, SPIE Proceedings