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Title: Lipid-peptide-polymer conjugates and nanoparticles thereof

The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1183465
Assignee:
Regents of the University of California (Oakland, CA) CHO
Patent Number(s):
9,044,514
Application Number:
13/610,637
Contract Number:
AC02-05CH11231
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY

Works referenced in this record:

Water self-diffusion in nonionic surfactant solutions. Hydration and obstruction effects
journal, November 1983
  • Nilsson, Per Gunnar; Lindman, Bjoern
  • The Journal of Physical Chemistry, Vol. 87, Issue 23, p. 4756-4761
  • DOI: 10.1021/j100246a041