Lipid-peptide-polymer conjugates and nanoparticles thereof
Abstract
The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.
- Inventors:
- Issue Date:
- Research Org.:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1183465
- Patent Number(s):
- 9044514
- Application Number:
- 13/610,637
- Assignee:
- Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY
Citation Formats
Xu, Ting, Dong, He, and Shu, Jessica. Lipid-peptide-polymer conjugates and nanoparticles thereof. United States: N. p., 2015.
Web.
Xu, Ting, Dong, He, & Shu, Jessica. Lipid-peptide-polymer conjugates and nanoparticles thereof. United States.
Xu, Ting, Dong, He, and Shu, Jessica. Tue .
"Lipid-peptide-polymer conjugates and nanoparticles thereof". United States. https://www.osti.gov/servlets/purl/1183465.
@article{osti_1183465,
title = {Lipid-peptide-polymer conjugates and nanoparticles thereof},
author = {Xu, Ting and Dong, He and Shu, Jessica},
abstractNote = {The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {6}
}
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