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Title: Bis-polymer lipid-peptide conjugates and nanoparticles thereof


The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.

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Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
OSTI Identifier:
Patent Number(s):
Application Number:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
Resource Type:
Resource Relation:
Patent File Date: 2014 Sep 18
Country of Publication:
United States

Citation Formats

Xu, Ting, Dong, He, Shu, Jessica, and Dube, Nikhil. Bis-polymer lipid-peptide conjugates and nanoparticles thereof. United States: N. p., 2018. Web.
Xu, Ting, Dong, He, Shu, Jessica, & Dube, Nikhil. Bis-polymer lipid-peptide conjugates and nanoparticles thereof. United States.
Xu, Ting, Dong, He, Shu, Jessica, and Dube, Nikhil. Tue . "Bis-polymer lipid-peptide conjugates and nanoparticles thereof". United States.
title = {Bis-polymer lipid-peptide conjugates and nanoparticles thereof},
author = {Xu, Ting and Dong, He and Shu, Jessica and Dube, Nikhil},
abstractNote = {The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {4}


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