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Title: Bis-polymer lipid-peptide conjugates and nanoparticles thereof

Abstract

The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1436688
Patent Number(s):
9949927
Application Number:
14/490,336
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Sep 18
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Xu, Ting, Dong, He, Shu, Jessica, and Dube, Nikhil. Bis-polymer lipid-peptide conjugates and nanoparticles thereof. United States: N. p., 2018. Web.
Xu, Ting, Dong, He, Shu, Jessica, & Dube, Nikhil. Bis-polymer lipid-peptide conjugates and nanoparticles thereof. United States.
Xu, Ting, Dong, He, Shu, Jessica, and Dube, Nikhil. Tue . "Bis-polymer lipid-peptide conjugates and nanoparticles thereof". United States. https://www.osti.gov/servlets/purl/1436688.
@article{osti_1436688,
title = {Bis-polymer lipid-peptide conjugates and nanoparticles thereof},
author = {Xu, Ting and Dong, He and Shu, Jessica and Dube, Nikhil},
abstractNote = {The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {4}
}

Patent:

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