Title: Bis-polymer lipid-peptide conjugates and nanoparticles thereof

Abstract

The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.

Inventors:

Xu, Ting; Dong, He; Shu, Jessica; Dube, Nikhil

Issue Date:

Tue Apr 24 00:00:00 EDT 2018

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1436688

Patent Number(s):

9949927

Application Number:

14/490,336

Assignee:

The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K2300/00 - Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K31/337 - having four-membered rings, e.g. taxol
A61K31/436 - the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K31/704 - attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {
A61K47/42 - Proteins
A61K47/62 - the modifying agent being a protein, peptide or polyamino acid
A61K47/6907 - {the form being a microemulsion, nanoemulsion or micelle}
A61K51/1227 - {Micelles, e.g. phospholipidic or polymeric micelles}
A61K9/1075 - {Microemulsions or submicron emulsions

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DOE Contract Number:  

AC02-05CH11231

Resource Type:

Patent

Resource Relation:

Patent File Date: 2014 Sep 18

Country of Publication:

United States

Language:

English

Subject:

36 MATERIALS SCIENCE