Bi-terminal pegylated integrin-binding peptides and methods of use thereof

Hausner, Sven H.; Sutcliffe, Julie L.

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Title: Bi-terminal pegylated integrin-binding peptides and methods of use thereof

Abstract

The present invention provides bi-terminal PEGylated peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates of the present invention further comprise a biological agent such as an imaging agent or a therapeutic agent, e.g., covalently attached to one of the PEG moieties. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating integrin-mediated diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, chronic fibrosis, chronic obstructive pulmonary disease (COPD), lung emphysema, and chronic wounding skin disease. Compositions and kits containing the peptide conjugates of the present invention find utility in a wide range of applications including, e.g., in vivo imaging and immunotherapy.

Inventors:: Hausner, Sven H.; Sutcliffe, Julie L.

Issue Date:: 2022-11-01

Research Org.:: Univ. of California, Davis, CA (United States)

Sponsoring Org.:: USDOE; National Institutes of Health (NIH)

OSTI Identifier:: 1986773

Patent Number(s):: 11485758

Application Number:: 17/131,324

Assignee:: The Regents of the University of California (Oakland, CA)

DOE Contract Number:: SC0002061; 1RC4EB012836-01

Resource Type:: Patent

Resource Relation:: Patent File Date: 12/22/2020

Country of Publication:: United States

Language:: English

Citation Formats


                    Hausner, Sven H., and Sutcliffe, Julie L. Bi-terminal pegylated integrin-binding peptides and methods of use thereof.  United States: N. p., 2022. 
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                    Hausner, Sven H., & Sutcliffe, Julie L. Bi-terminal pegylated integrin-binding peptides and methods of use thereof.  United States.

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                    Hausner, Sven H., and Sutcliffe, Julie L. Tue .  
        "Bi-terminal pegylated integrin-binding peptides and methods of use thereof".  United States.  https://www.osti.gov/servlets/purl/1986773.

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@article{osti_1986773,

  title        = {Bi-terminal pegylated integrin-binding peptides and methods of use thereof},

  author       = {Hausner, Sven H. and Sutcliffe, Julie L.},

  abstractNote = {The present invention provides bi-terminal PEGylated peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates of the present invention further comprise a biological agent such as an imaging agent or a therapeutic agent, e.g., covalently attached to one of the PEG moieties. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating integrin-mediated diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, chronic fibrosis, chronic obstructive pulmonary disease (COPD), lung emphysema, and chronic wounding skin disease. Compositions and kits containing the peptide conjugates of the present invention find utility in a wide range of applications including, e.g., in vivo imaging and immunotherapy.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2022},

  month        = {11}

}

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